PMID- 24560686
OWN - NLM
STAT- MEDLINE
DCOM- 20141216
LR  - 20211021
IS  - 1879-016X (Electronic)
IS  - 0163-7258 (Print)
IS  - 0163-7258 (Linking)
VI  - 143
IP  - 1
DP  - 2014 Jul
TI  - Brain-derived neurotrophic factor in the airways.
PG  - 74-86
LID - S0163-7258(14)00045-X [pii]
LID - 10.1016/j.pharmthera.2014.02.006 [doi]
AB  - In addition to their well-known roles in the nervous system, there is increasing 
      recognition that neurotrophins such as brain derived neurotrophic factor (BDNF) 
      as well as their receptors are expressed in peripheral tissues including the 
      lung, and can thus potentially contribute to both normal physiology and 
      pathophysiology of several diseases. The relevance of this family of growth 
      factors lies in emerging clinical data indicating altered neurotrophin levels and 
      function in a range of diseases including neonatal and adult asthma, sinusitis, 
      influenza, and lung cancer. The current review focuses on 1) the importance of 
      BDNF expression and signaling mechanisms in early airway and lung development, 
      critical to both normal neonatal lung function and also its disruption in 
      prematurity and insults such as inflammation and infection; 2) how BDNF, 
      potentially derived from airway nerves modulate neurogenic control of airway 
      tone, a key aspect of airway reflexes as well as dysfunctional responses to 
      allergic inflammation; 3) the emerging idea that local BDNF production by 
      resident airway cells such as epithelium and airway smooth muscle can contribute 
      to normal airway structure and function, and to airway hyperreactivity and 
      remodeling in diseases such as asthma. Furthermore, given its pleiotropic effects 
      in the airway, BDNF may be a novel and appealing therapeutic target.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Prakash, Y S
AU  - Prakash YS
AD  - Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, MN 
      55905, United States; Department of Physiology & Biomedical Engineering, Mayo 
      Clinic College of Medicine, Rochester, MN 55905, United States. Electronic 
      address: prakash.ys@mayo.edu.
FAU - Martin, Richard J
AU  - Martin RJ
AD  - Department of Pediatrics, Rainbow Babies and Children's Hospital, Case Western 
      Reserve University, Cleveland, OH 44106, United States.
LA  - eng
GR  - HL056470/HL/NHLBI NIH HHS/United States
GR  - HL088029/HL/NHLBI NIH HHS/United States
GR  - UL1 TR000135/TR/NCATS NIH HHS/United States
GR  - R01 HL056470/HL/NHLBI NIH HHS/United States
GR  - R01 HL088029/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20140219
PL  - England
TA  - Pharmacol Ther
JT  - Pharmacology & therapeutics
JID - 7905840
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Asthma/etiology
MH  - Brain-Derived Neurotrophic Factor/genetics/*physiology
MH  - Bronchi/physiology
MH  - Calcium/metabolism
MH  - Environmental Exposure
MH  - Humans
MH  - Lung/embryology/innervation/*physiology
MH  - Muscle, Smooth/physiology
MH  - Pulmonary Fibrosis/etiology
MH  - Receptor, trkB/physiology
MH  - Signal Transduction/physiology
PMC - PMC3990251
MID - NIHMS568320
OTO - NOTNLM
OT  - Asthma
OT  - Development
OT  - Fibrosis
OT  - Inflammation
OT  - Lung
OT  - Neurotrophin
COIS- Financial and Competing Interests Disclosure: The authors have nothing to declare 
      in terms of financial or other conflicts of interest relevant to the subject 
      matter of materials discussed in this review. This includes employment, 
      consultancies, honoraria, stock ownership or options, expert testimony, grants or 
      patents received or pending, or royalties.
EDAT- 2014/02/25 06:00
MHDA- 2014/12/17 06:00
PMCR- 2015/07/01
CRDT- 2014/02/25 06:00
PHST- 2014/02/10 00:00 [received]
PHST- 2014/02/10 00:00 [accepted]
PHST- 2014/02/25 06:00 [entrez]
PHST- 2014/02/25 06:00 [pubmed]
PHST- 2014/12/17 06:00 [medline]
PHST- 2015/07/01 00:00 [pmc-release]
AID - S0163-7258(14)00045-X [pii]
AID - 10.1016/j.pharmthera.2014.02.006 [doi]
PST - ppublish
SO  - Pharmacol Ther. 2014 Jul;143(1):74-86. doi: 10.1016/j.pharmthera.2014.02.006. 
      Epub 2014 Feb 19.