PMID- 24561536
OWN - NLM
STAT- MEDLINE
DCOM- 20141201
LR  - 20140407
IS  - 1872-7077 (Electronic)
IS  - 1382-6689 (Linking)
VI  - 37
IP  - 2
DP  - 2014 Mar
TI  - Semiquinone glucoside derivative (SQGD) isolated from Bacillus sp. INM-1 protects 
      against gamma radiation-induced oxidative stress.
PG  - 553-62
LID - S1382-6689(14)00004-0 [pii]
LID - 10.1016/j.etap.2014.01.003 [doi]
AB  - In the present study, radioprotective potential of Semiquinone glucoside 
      derivative (SQGD) isolated from radioresistant bacterium Bacillus sp. INM-1 was 
      evaluated. gamma-Radiation induced protein carbonylation, plasmid DNA damage, enzyme 
      functional impairment, lipid peroxidation, HO radicals generation and their 
      protection by SQGD was assessed. As a result of SQGD treatment, significant 
      inhibition (p<0.05) in protein carbonylation was observed with BSA. SQGD 
      treatment was found to restore supercoiled (~70+/-3.21%) form of irradiated plasmid 
      DNA against gamma-irradiation. SQGD protects enzymes (EcoR1 and BamH1) against 
      radiation-induced dysfunctioning. SQGD significantly inhibited (p<0.05) lipid 
      peroxidation in liposomes, brain and liver homogenate. Higher HO(*) 
      radicals-averting activity of SQGD was observed in the serum and liver homogenate 
      of C57BL/6 mice against H2O2-induced oxidative stress. In conclusion, SQGD 
      demonstrates excellent radical-scavenging activity towards bio-macromolecules in 
      irradiated environment and can be developed as an ideal radioprotector against 
      radiation-induced oxidative stress in future.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Mishra, Saurabh
AU  - Mishra S
AD  - Radiation Biotechnology Laboratory, Department of Radiation Biosciences, 
      Institute of Nuclear and Allied Sciences, Delhi 110054, India.
FAU - Malhotra, Poonam
AU  - Malhotra P
AD  - Radiation Biotechnology Laboratory, Department of Radiation Biosciences, 
      Institute of Nuclear and Allied Sciences, Delhi 110054, India.
FAU - Gupta, Ashutosh K
AU  - Gupta AK
AD  - Radiation Biotechnology Laboratory, Department of Radiation Biosciences, 
      Institute of Nuclear and Allied Sciences, Delhi 110054, India.
FAU - Singh, Praveen K
AU  - Singh PK
AD  - Radiation Biotechnology Laboratory, Department of Radiation Biosciences, 
      Institute of Nuclear and Allied Sciences, Delhi 110054, India.
FAU - Javed, Saleem
AU  - Javed S
AD  - Department of Biochemistry, Faculty of Science, Jamia Hamdard, Delhi 110062, 
      India.
FAU - Kumar, Raj
AU  - Kumar R
AD  - Radiation Biotechnology Laboratory, Department of Radiation Biosciences, 
      Institute of Nuclear and Allied Sciences, Delhi 110054, India; Department of 
      Biochemistry, Faculty of Science, Jamia Hamdard, Delhi 110062, India. Electronic 
      address: rajkumar790@yahoo.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140125
PL  - Netherlands
TA  - Environ Toxicol Pharmacol
JT  - Environmental toxicology and pharmacology
JID - 9612020
RN  - 0 (Glucosides)
RN  - 0 (Liposomes)
RN  - 0 (Quinones)
RN  - 0 (Radiation-Protective Agents)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - 3352-57-6 (Hydroxyl Radical)
RN  - 4Y8F71G49Q (Malondialdehyde)
SB  - IM
MH  - Animals
MH  - *Bacillus
MH  - Brain/drug effects/metabolism
MH  - DNA Damage/drug effects
MH  - Gamma Rays/*adverse effects
MH  - Glucosides/*pharmacology
MH  - Hydroxyl Radical/metabolism
MH  - Intestines
MH  - Liposomes
MH  - Liver/drug effects/metabolism
MH  - Malondialdehyde/metabolism
MH  - Mice, Inbred C57BL
MH  - Oxidative Stress/drug effects
MH  - Quinones/*pharmacology
MH  - Radiation-Protective Agents/*pharmacology
MH  - Thiobarbituric Acid Reactive Substances/metabolism
OTO - NOTNLM
OT  - Antioxidant
OT  - Carbonylation
OT  - Lipid-peroxidation
OT  - Oxidative stress
OT  - Restriction enzyme
OT  - Toxicity
EDAT- 2014/02/25 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/02/25 06:00
PHST- 2013/08/12 00:00 [received]
PHST- 2014/01/03 00:00 [revised]
PHST- 2014/01/09 00:00 [accepted]
PHST- 2014/02/25 06:00 [entrez]
PHST- 2014/02/25 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - S1382-6689(14)00004-0 [pii]
AID - 10.1016/j.etap.2014.01.003 [doi]
PST - ppublish
SO  - Environ Toxicol Pharmacol. 2014 Mar;37(2):553-62. doi: 
      10.1016/j.etap.2014.01.003. Epub 2014 Jan 25.