PMID- 24561694
OWN - NLM
STAT- MEDLINE
DCOM- 20140912
LR  - 20201209
IS  - 2233-6869 (Electronic)
IS  - 1598-9992 (Linking)
VI  - 63
IP  - 2
DP  - 2014 Feb
TI  - [Trends in the eradication rates of Helicobacter pylori infection in Daegu and 
      Gyeongsangbuk-do, Korea: multicenter study over 13 years].
PG  - 82-9
AB  - BACKGROUND/AIMS: The eradication rates of Helicobacter pylori infection have been 
      reported to have decreased over the years due to antibiotics resistance. The aim 
      of this study is to investigate the trend of eradication rates of first-line 
      triple therapy for H. pylori over the past 13 year period, and to evaluate 
      factors affecting H. pylori eradication in Daegu and Gyeongsangbuk-do, Korea. 
      METHODS: A total of 2,982 patients with H. pylori infection who were treated with 
      either 1 week or 2 weeks first-line therapy (proton pump inhibitor [PPI], 
      amoxicillin, and clarithromycin) from January 1999 through December 2011 were 
      included in this study. Data were collected by retrospectively reviewing the 
      medical records. RESULTS: The overall H. pylori eradication rate was 87.2%. The 
      eradication rates from 1999 to 2011 fluctuated between 78.0% and 95.7%, but no 
      definite evidence of a decreasing tendency was seen over the 13 year period 
      (p=0.113). Furthermore, there was no significant difference in the eradication 
      rate according to the duration of therapy (p=0.592). However, there was a 
      significant difference in the eradication rate among various PPIs (p<0.01). 
      CONCLUSIONS: There was no decreasing trend in the H. pylori eradication rate over 
      the past 13 years in Daegu and Gyeongsangbuk-do, Korea. There also was no 
      difference in the eradication rates depending on duration of therapy. However, a 
      significant difference was noted among various PPIs.
FAU - Jung, Yeoun Su
AU  - Jung YS
AD  - Division of Gastroenterology and Hepatology, Department of Internal Medicine, 
      Yeungnam University College of Medicine, 170 Hyeonchung-ro, Nam-gu, Daegu 
      705-717, Korea.
FAU - Lee, Si Hyung
AU  - Lee SH
FAU - Park, Chan Seo
AU  - Park CS
FAU - Oh, Myung Jin
AU  - Oh MJ
FAU - Kim, Kyeong Ok
AU  - Kim KO
FAU - Jang, Byung Ik
AU  - Jang BI
FAU - Jeon, Seong Woo
AU  - Jeon SW
FAU - Jung, Min Kyu
AU  - Jung MK
FAU - Park, Kyung Sik
AU  - Park KS
FAU - Kim, Eun Soo
AU  - Kim ES
FAU - Cho, Kwang Bum
AU  - Cho KB
FAU - Jung, Jin Tae
AU  - Jung JT
FAU - Kwon, Joong Goo
AU  - Kwon JG
FAU - Kim, Eun Young
AU  - Kim EY
FAU - Kim, Wan Jung
AU  - Kim WJ
FAU - Yang, Chang Heon
AU  - Yang CH
LA  - kor
PT  - Journal Article
PT  - Multicenter Study
PL  - Korea (South)
TA  - Korean J Gastroenterol
JT  - The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
JID - 101189416
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Proton Pump Inhibitors)
RN  - 32828355LL (Rabeprazole)
RN  - 804826J2HU (Amoxicillin)
RN  - H1250JIK0A (Clarithromycin)
RN  - KG60484QX9 (Omeprazole)
RN  - N3PA6559FT (Esomeprazole)
SB  - IM
CIN - Korean J Gastroenterol. 2014 Feb;63(2):63-5. PMID: 24707549
MH  - Adult
MH  - Aged
MH  - Amoxicillin/therapeutic use
MH  - Anti-Bacterial Agents/*therapeutic use
MH  - Clarithromycin/therapeutic use
MH  - Disease Eradication/*trends
MH  - Drug Administration Schedule
MH  - Drug Therapy, Combination
MH  - Endoscopy, Gastrointestinal
MH  - Esomeprazole/therapeutic use
MH  - Female
MH  - Helicobacter Infections/*drug therapy/pathology
MH  - *Helicobacter pylori
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Omeprazole/therapeutic use
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Rabeprazole/therapeutic use
MH  - Republic of Korea
MH  - Retrospective Studies
MH  - Treatment Outcome
EDAT- 2014/02/25 06:00
MHDA- 2014/09/13 06:00
CRDT- 2014/02/25 06:00
PHST- 2014/02/25 06:00 [entrez]
PHST- 2014/02/25 06:00 [pubmed]
PHST- 2014/09/13 06:00 [medline]
AID - 201402193 [pii]
AID - 10.4166/kjg.2014.63.2.82 [doi]
PST - ppublish
SO  - Korean J Gastroenterol. 2014 Feb;63(2):82-9. doi: 10.4166/kjg.2014.63.2.82.