PMID- 24563186
OWN - NLM
STAT- MEDLINE
DCOM- 20150126
LR  - 20211021
IS  - 1432-2072 (Electronic)
IS  - 0033-3158 (Linking)
VI  - 231
IP  - 8
DP  - 2014 Apr
TI  - Effect of age on methylphenidate-induced conditioned taste avoidance and related 
      BDNF/TrkB signaling in the insular cortex of the rat.
PG  - 1493-501
LID - 10.1007/s00213-014-3500-y [doi]
AB  - RATIONALE: Drug use and abuse is thought to be a function of the balance between 
      its rewarding and aversive effects, such that the rewarding effects increase the 
      likelihood of use while the drug's dissociable aversive effects limit it. 
      Adolescents exhibit a shift in this balance toward reward, which may ultimately 
      lead to increased use. Importantly, recent work shows that adolescents are also 
      protected from the aversive effects of many abusable drugs as measured by 
      conditioned taste avoidance (CTA). However, such effects of methylphenidate (MPH, 
      widely prescribed to adolescents with ADHD) have not been characterized. 
      OBJECTIVES: The effect of age on MPH-induced CTA was assessed. In addition, 
      MPH-induced changes in brain-derived neurotrophic factor (BDNF) activity in the 
      insular cortex (IC) and central nucleus of the amygdala (CeA), known to be 
      important to CTA, were examined and related to CTAs in adolescents and adults. 
      METHODS: CTAs induced by MPH (0, 10, 18, and 32 mg/kg) were assessed in 
      adolescent (n = 34) and adult (n = 33) male Sprague Dawley rats. Following MPH 
      CTA, IC and CeA tissue was probed for differences in BDNF and tropomyosin-related 
      kinase receptor-B (TrkB) using Western blots. RESULTS: Blunted expression of MPH 
      CTA was observed in the adolescents versus adults, which correlated with 
      generally attenuated adolescent BDNF/TrkB activity in the IC, but the drug 
      effects ran contrary to the expression of CTA. CONCLUSIONS: Adolescents are 
      protected from the aversive effects of MPH versus adults, but further work is 
      needed to characterize the possible involvement of BDNF/TrkB.
FAU - Wetzell, B Bradley
AU  - Wetzell BB
AD  - Psychopharmacology Laboratory, Department of Psychology, American University, 
      4400 Massachusetts Avenue NW, Washington, DC, 20016, USA, 
      bradley.wetzell@american.edu.
FAU - Muller, Mirabella M
AU  - Muller MM
FAU - Cobuzzi, Jennifer L
AU  - Cobuzzi JL
FAU - Hurwitz, Zachary E
AU  - Hurwitz ZE
FAU - DeCicco-Skinner, Kathleen
AU  - DeCicco-Skinner K
FAU - Riley, Anthony L
AU  - Riley AL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140222
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Dopamine Uptake Inhibitors)
RN  - 207ZZ9QZ49 (Methylphenidate)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - FST467XS7D (Saccharin)
SB  - IM
MH  - Animals
MH  - Avoidance Learning/*drug effects/physiology
MH  - Blotting, Western
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Central Amygdaloid Nucleus/drug effects/growth & development/physiology
MH  - Cerebral Cortex/*drug effects/growth & development/physiology
MH  - Conditioning, Classical/*drug effects/physiology
MH  - Dopamine Uptake Inhibitors/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Eating/drug effects/physiology
MH  - Male
MH  - Methylphenidate/*pharmacology
MH  - Phosphorylation
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkB/metabolism
MH  - Saccharin/administration & dosage
MH  - Signal Transduction
MH  - Taste Perception/*drug effects/physiology
EDAT- 2014/02/25 06:00
MHDA- 2015/01/27 06:00
CRDT- 2014/02/25 06:00
PHST- 2013/10/21 00:00 [received]
PHST- 2014/02/07 00:00 [accepted]
PHST- 2014/02/25 06:00 [entrez]
PHST- 2014/02/25 06:00 [pubmed]
PHST- 2015/01/27 06:00 [medline]
AID - 10.1007/s00213-014-3500-y [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2014 Apr;231(8):1493-501. doi: 
      10.1007/s00213-014-3500-y. Epub 2014 Feb 22.