PMID- 24564769 OWN - NLM STAT- MEDLINE DCOM- 20141105 LR - 20171116 IS - 1744-8395 (Electronic) IS - 1476-0584 (Linking) VI - 13 IP - 4 DP - 2014 Apr TI - CD11b+ DCs rediscovered: implications for vaccination. PG - 445-7 LID - 10.1586/14760584.2014.893196 [doi] AB - Dendritic cells (DCs) are potent antigen sensing and presenting cells, able to both initiate and orchestrate complex immune responses. DCs are optimally equipped to recognize pathogens, as well as self-antigens and vaccine components, and instruct the type, magnitude and specificity of the ensuing immunity. However, the DC population is remarkably heterogeneous and consists of multiple subsets with different ontogeny, differentiation and functional specializations. Therefore, a deeper understanding of DC subset biology is fundamental for the development and implementation of innovative vaccination strategies. FAU - Ginhoux, Florent AU - Ginhoux F AD - Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Biopolis, 138648, Singapore. FAU - Schlitzer, Andreas AU - Schlitzer A LA - eng PT - Editorial PT - Research Support, Non-U.S. Gov't DEP - 20140225 PL - England TA - Expert Rev Vaccines JT - Expert review of vaccines JID - 101155475 RN - 0 (CD11b Antigen) RN - 0 (ITGAM protein, human) RN - 0 (Vaccines) SB - IM MH - CD11b Antigen/*analysis MH - Dendritic Cells/*chemistry/*immunology MH - Humans MH - Vaccination MH - Vaccines/*immunology EDAT- 2014/02/26 06:00 MHDA- 2014/11/06 06:00 CRDT- 2014/02/26 06:00 PHST- 2014/02/26 06:00 [entrez] PHST- 2014/02/26 06:00 [pubmed] PHST- 2014/11/06 06:00 [medline] AID - 10.1586/14760584.2014.893196 [doi] PST - ppublish SO - Expert Rev Vaccines. 2014 Apr;13(4):445-7. doi: 10.1586/14760584.2014.893196. Epub 2014 Feb 25.