PMID- 24564845
OWN - NLM
STAT- MEDLINE
DCOM- 20141203
LR  - 20220408
IS  - 1532-4311 (Electronic)
IS  - 0882-0139 (Linking)
VI  - 43
IP  - 4
DP  - 2014
TI  - Polymorphism of costimulatory molecules (CTLA4, ICOS, PD.1 and CD28) and 
      allogeneic hematopoietic stem cell transplantation in Iranian patients.
PG  - 391-404
LID - 10.3109/08820139.2013.879594 [doi]
AB  - Costimulatory molecules are important factors determining the outcome of bone 
      marrow transplant. Because the host ability in costimulatory molecule function 
      may be affected by gene polymorphisms, the aim of the present study was to 
      investigate the effect of CTLA4, ICOS, PD.1 and CD28 gene polymorphisms in 
      outcome of bone marrow transplant patients. A total of 72 recipients were 
      included in this study. CTLA4 (-1722, -1661, -318, +49), ICOS (+1720), CD28 (+17) 
      and PD.1 (PD.1.3, PD.1.9) gene polymorphisms were evaluated by PCR-RFLP. The 
      results showed that no differences in the distribution of all mentioned 
      costimulatory molecules genotypes and alleles were observed in the Graft Versus 
      Host Disease (GVHD) group compared to the non-GVHD group. After gender 
      classification, there is a significant association between GA genotype 
      (CTLA4-1661) in male group with GVHD than without GVHD (p=0.03). Also, in this 
      study we found significant associations between CC genotype and C allele of 
      PD.1.9, and TT genotype and T allele of CD28 that had more frequency in grades 
      2-4 (p=0.04. p=0.02, p=0.01, p=0.003, respectively). Results indicate that the CC 
      genotype and C allele of PD.1.9 and TT genotype and the T allele of CD28 are 
      genetic risk factors for development of a severe grade of GVHD. This subject 
      needs to be studied in different population.
FAU - Iravani-Saadi, Mahdiyar
AU  - Iravani-Saadi M
AD  - Transplant Research Center, Shiraz University of Medical Sciences , Shiraz , Iran 
      .
FAU - Karimi, Mohammad Hossein
AU  - Karimi MH
FAU - Yaghobi, Ramin
AU  - Yaghobi R
FAU - Geramizadeh, Bita
AU  - Geramizadeh B
FAU - Ramzi, Mani
AU  - Ramzi M
FAU - Niknam, Ahmad
AU  - Niknam A
FAU - Pourfathollah, Arefeh
AU  - Pourfathollah A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140224
PL  - England
TA  - Immunol Invest
JT  - Immunological investigations
JID - 8504629
RN  - 0 (CD28 Antigens)
RN  - 0 (CTLA-4 Antigen)
RN  - 0 (Inducible T-Cell Co-Stimulator Protein)
RN  - 0 (Programmed Cell Death 1 Receptor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - CD28 Antigens/*genetics
MH  - CTLA-4 Antigen/*genetics
MH  - Child
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Graft vs Host Disease/*etiology
MH  - Haplotypes
MH  - *Hematopoietic Stem Cell Transplantation/adverse effects
MH  - Humans
MH  - Inducible T-Cell Co-Stimulator Protein/*genetics
MH  - Iran
MH  - Linkage Disequilibrium
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Programmed Cell Death 1 Receptor/*genetics
MH  - Transplantation, Homologous
MH  - Young Adult
EDAT- 2014/02/26 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/02/26 06:00
PHST- 2014/02/26 06:00 [entrez]
PHST- 2014/02/26 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - 10.3109/08820139.2013.879594 [doi]
PST - ppublish
SO  - Immunol Invest. 2014;43(4):391-404. doi: 10.3109/08820139.2013.879594. Epub 2014 
      Feb 24.