PMID- 2456574
OWN - NLM
STAT- MEDLINE
DCOM- 19880907
LR  - 20190501
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 85
IP  - 15
DP  - 1988 Aug
TI  - Absence of methylation of a CpG-rich region at the 5' end of the MIC2 gene on the 
      active X, the inactive X, and the Y chromosome.
PG  - 5605-9
AB  - We have identified and characterized a Hpa II tiny fragment (HTF) island 
      associated with the promoter region of the pseudoautosomal gene MIC2. The MIC2 
      HTF island is unmethylated on both the active and inactive X chromosome and is 
      similarly unmethylated on the Y chromosome. Unlike the majority of genes borne on 
      the X chromosome, MIC2 fails to undergo X chromosome inactivation. HTF islands 
      associated with X chromosome-linked genes that are inactivated are highly 
      methylated on the inactive or transcriptionally silent homologue. The failure of 
      MIC2 to undergo X chromosome inactivation correlates with the lack of methylation 
      of the HTF island at the 5' end of the gene. These results provide further 
      evidence that DNA methylation plays an important role in the phenomenon of X 
      chromosome inactivation.
FAU - Goodfellow, P J
AU  - Goodfellow PJ
AD  - Human Molecular Genetics Laboratory, Imperial Cancer Research Fund, London, 
      England.
FAU - Mondello, C
AU  - Mondello C
FAU - Darling, S M
AU  - Darling SM
FAU - Pym, B
AU  - Pym B
FAU - Little, P
AU  - Little P
FAU - Goodfellow, P N
AU  - Goodfellow PN
LA  - eng
SI  - GENBANK/J03841
SI  - GENBANK/M22556
PT  - Journal Article
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Antigens, Surface)
RN  - 9007-49-2 (DNA)
RN  - EC 3.1.21.- (DNA Restriction Enzymes)
RN  - EC 3.1.21.- (Deoxyribonuclease HpaII)
SB  - IM
MH  - Antigens, Surface/*genetics
MH  - Base Sequence
MH  - Cell Line
MH  - Cosmids
MH  - DNA/*metabolism
MH  - DNA Restriction Enzymes
MH  - Deoxyribonuclease HpaII
MH  - *Dosage Compensation, Genetic
MH  - Female
MH  - Gene Expression Regulation
MH  - Humans
MH  - Male
MH  - Methylation
MH  - Molecular Sequence Data
MH  - Nucleic Acid Hybridization
MH  - Promoter Regions, Genetic
MH  - X Chromosome/*metabolism
MH  - Y Chromosome/*metabolism
PMC - PMC281808
EDAT- 1988/08/01 00:00
MHDA- 1988/08/01 00:01
PMCR- 1989/02/01
CRDT- 1988/08/01 00:00
PHST- 1988/08/01 00:00 [pubmed]
PHST- 1988/08/01 00:01 [medline]
PHST- 1988/08/01 00:00 [entrez]
PHST- 1989/02/01 00:00 [pmc-release]
AID - 10.1073/pnas.85.15.5605 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1988 Aug;85(15):5605-9. doi: 10.1073/pnas.85.15.5605.