PMID- 24565925
OWN - NLM
STAT- MEDLINE
DCOM- 20141118
LR  - 20140331
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1558
DP  - 2014 Apr 16
TI  - Testosterone enhances functional recovery after stroke through promotion of 
      antioxidant defenses, BDNF levels and neurogenesis in male rats.
PG  - 74-83
LID - S0006-8993(14)00242-X [pii]
LID - 10.1016/j.brainres.2014.02.028 [doi]
AB  - It is reported that circulating testosterone levels decrease after cerebral 
      ischemia. The aim of this study was to evaluate the effects of testosterone on 
      oxidative stress, brain-derived neurotrophic factor (BDNF) levels, neurogenesis, 
      histological damage and sensorimotor recovery in a castrated male rat model of 
      focal cerebral ischemia. Animals were divided into four groups. For all animals, 
      castrations were conducted 7 days before transient middle cerebral artery 
      occlusion (MCAO) was done and cerebral ischemia was induced. The first group 
      served as sham. Second was MCAO group and received vehicle only, third was MCAO 
      group that was post-treated with testosterone and the fourth was MCAO group 
      post-treated with testosterone and flutamide. Treatment only with testosterone 
      significantly weakened oxidative stress and increased BDNF levels and 
      sensorimotor recovery during a 10 days period. Rats receiving testosterone 
      demonstrated a significant reduction in infarct volume and a significant increase 
      in neurogenesis on 10th day after focal cerebral ischemia. Our results for the 
      first time showed a potential advantageous effect of testosterone after cerebral 
      ischemia in male rats, which was probably mediated by promoting antioxidant 
      defenses, BDNF levels and neurogenesis.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Fanaei, Hamed
AU  - Fanaei H
AD  - Department of Physiology, School of Medicine, Zahedan University of Medical 
      Sciences, Zahedan, Iran. Electronic address: fanaei@razi.tums.ac.ir.
FAU - Karimian, Seyed Morteza
AU  - Karimian SM
AD  - Department of Physiology, School of Medicine, Tehran University of Medical 
      Sciences, Tehran, Iran.
FAU - Sadeghipour, Hamid Reza
AU  - Sadeghipour HR
AD  - Department of Physiology, School of Medicine, Tehran University of Medical 
      Sciences, Tehran, Iran.
FAU - Hassanzade, Gholamreza
AU  - Hassanzade G
AD  - Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, 
      Tehran, Iran; Department of Neuroscience, School of Advanced Technologies in 
      Medicine, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Kasaeian, Amir
AU  - Kasaeian A
AD  - Non-Communicable Diseases Research Center, Endocrinology and Metabolism 
      Population Sciences Institute, Tehran University of Medical Sciences, Tehran, 
      Iran; Department of Epidemiology and Biostatistics, School of Public Health, 
      Tehran University of Medical Sciences, Tehran, Iran.
FAU - Attari, Fatemeh
AU  - Attari F
AD  - Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran 
      University of Medical Sciences, Tehran, Iran.
FAU - Khayat, Samira
AU  - Khayat S
AD  - Nursing and Midwifery Faculty, Shahid Beheshti University of Medical Sciences, 
      Tehran, Iran.
FAU - Ramezani, Vahid
AU  - Ramezani V
AD  - Department of Pharmaceutics, Faculty of Pharmacy, Shahid Sadoughi University of 
      Medical Sciences, Yazd, Iran.
FAU - Javadimehr, Mani
AU  - Javadimehr M
AD  - Department of Medical English Language, School of Medicine, Zahedan University of 
      Medical Sciences, Zahedan, Iran.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20140222
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Antioxidants)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neuroprotective Agents)
RN  - 3XMK78S47O (Testosterone)
RN  - 4Y8F71G49Q (Malondialdehyde)
SB  - IM
MH  - Animals
MH  - Antioxidants/*metabolism
MH  - Brain Infarction/etiology/prevention & control
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Disease Models, Animal
MH  - Infarction, Middle Cerebral Artery/*drug therapy/mortality
MH  - Locomotion/drug effects
MH  - Male
MH  - Malondialdehyde/blood
MH  - Neurogenesis/*drug effects
MH  - Neuroprotective Agents/*therapeutic use
MH  - Oxidative Stress/drug effects
MH  - Psychomotor Disorders/drug therapy/etiology
MH  - Rats
MH  - Rats, Wistar
MH  - Recovery of Function/*drug effects
MH  - Testosterone/blood/*therapeutic use
MH  - Time Factors
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Neurogenesis
OT  - Oxidative stress
OT  - Stroke
OT  - Testosterone
EDAT- 2014/02/26 06:00
MHDA- 2014/11/19 06:00
CRDT- 2014/02/26 06:00
PHST- 2013/07/08 00:00 [received]
PHST- 2014/01/25 00:00 [revised]
PHST- 2014/02/14 00:00 [accepted]
PHST- 2014/02/26 06:00 [entrez]
PHST- 2014/02/26 06:00 [pubmed]
PHST- 2014/11/19 06:00 [medline]
AID - S0006-8993(14)00242-X [pii]
AID - 10.1016/j.brainres.2014.02.028 [doi]
PST - ppublish
SO  - Brain Res. 2014 Apr 16;1558:74-83. doi: 10.1016/j.brainres.2014.02.028. Epub 2014 
      Feb 22.