PMID- 24566094
OWN - NLM
STAT- MEDLINE
DCOM- 20150518
LR  - 20221207
IS  - 1473-5571 (Electronic)
IS  - 0269-9370 (Linking)
VI  - 28
IP  - 7
DP  - 2014 Apr 24
TI  - HLA-B*35: 05 is a protective allele with a unique structure among HIV-1 
      CRF01_AE-infected Thais, in whom the B*57 frequency is low.
PG  - 959-67
LID - 10.1097/QAD.0000000000000206 [doi]
AB  - OBJECTIVE: To identify protective human leukocyte antigen (HLA) alleles in an 
      HIV-infected south-east Asian population, in whom HLA-B*57 prevalence is lower 
      than other ethnic groups, and HIV-1 CRF01_AE is the dominant circulating subtype. 
      DESIGN: Cross-sectional study of Thai patients with chronic HIV infection. 
      METHODS: Five hundred and fifty-seven HIV-1 CRF01_AE-infected Thais were 
      recruited. Their HLA type and viral load were determined to statistically analyze 
      the association of each allele in viral control. In-silico molecular dynamics was 
      also used to evaluate the effect of HLA structure variants on epitope binding. 
      RESULTS: HLA-B*35:05 was identified as the most protective allele (P=0.003, 
      q=0.17), along with HLA-B*57:01 (P=0.044, q=0.31). Structurally, HLA-B*35:05 
      belonged to the HLA-B*35-PY group of HLA-B*35 alleles; however, unlike the other 
      HLA-B*35 alleles that carry Arg (R) at residue 97, it has unique sequences at 
      T94, L95, and S97, located within the peptide-binding groove. Analysis of the 
      three-dimensional HLA structure and molecular dynamics indicates that S97 in 
      HLA-B*35:05 leads to less flexibility in the groove, and shorter distances 
      between the alpha-helixes compared with the disease-susceptible HLA-B*35-PY allele, 
      HLA-B*35:01. CONCLUSION: These data indicate the existence of a protective effect 
      of HLA-B*57 across ethnic groups and highlight HLA-B*35:05 as an allele uniquely 
      protective in subtype CRF01_AE-infected Thais. The divergence of HLA-B*35:05 from 
      conventional HLA-B*35-PY structural sequences at the peptide-binding groove is 
      consistent with previous studies that have identified HLA residue 97 as strongly 
      influential in shaping HLA impact on immune control of HIV, and that a more 
      restricted peptide-binding motif may be associated with improved control.
FAU - Mori, Masahiko
AU  - Mori M
AD  - Department of Clinical Medicine, Institute of Tropical Medicine, Nagasaki 
      University, Sakamoto, Nagasaki City, Nagasaki, Japan.
FAU - Wichukchinda, Nuanjun
AU  - Wichukchinda N
FAU - Miyahara, Reiko
AU  - Miyahara R
FAU - Rojanawiwat, Archawin
AU  - Rojanawiwat A
FAU - Pathipvanich, Panita
AU  - Pathipvanich P
FAU - Maekawa, Tomoyuki
AU  - Maekawa T
FAU - Miura, Toshiyuki
AU  - Miura T
FAU - Goulder, Philip
AU  - Goulder P
FAU - Yasunami, Michio
AU  - Yasunami M
FAU - Ariyoshi, Koya
AU  - Ariyoshi K
FAU - Sawanpanyalert, Pathom
AU  - Sawanpanyalert P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - AIDS
JT  - AIDS (London, England)
JID - 8710219
RN  - 0 (HLA-B35 Antigen)
SB  - IM
EIN - AIDS. 2015 Jun 19;29(10):1275
MH  - Adolescent
MH  - Adult
MH  - Animals
MH  - Asian People
MH  - Cross-Sectional Studies
MH  - *Disease Resistance
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - HIV Infections/*epidemiology/*immunology/virology
MH  - HIV-1/*immunology/isolation & purification
MH  - HLA-B35 Antigen/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Thailand
MH  - Viral Load
MH  - Young Adult
EDAT- 2014/02/26 06:00
MHDA- 2015/05/20 06:00
CRDT- 2014/02/26 06:00
PHST- 2014/02/26 06:00 [entrez]
PHST- 2014/02/26 06:00 [pubmed]
PHST- 2015/05/20 06:00 [medline]
AID - 10.1097/QAD.0000000000000206 [doi]
PST - ppublish
SO  - AIDS. 2014 Apr 24;28(7):959-67. doi: 10.1097/QAD.0000000000000206.