PMID- 24566146
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20211021
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 15
IP  - 2
DP  - 2014 Feb 21
TI  - The neuroprotective role of acupuncture and activation of the BDNF signaling 
      pathway.
PG  - 3234-52
LID - 10.3390/ijms15023234 [doi]
AB  - Recent studies have been conducted to examine the neuroprotective effects of 
      acupuncture in many neurological disorders. Although the neuroprotective effects 
      of acupuncture has been linked to changes in signaling pathways, accumulating 
      evidence suggest the participation of endogenous biological mediators, such as 
      the neurotrophin (NT) family of proteins, specifically, the brain derived 
      neurotrophic factor (BDNF). Accordingly, acupuncture can inhibit 
      neurodegeneration via expression and activation of BDNF. Moreover, recent studies 
      have reported that acupuncture can increase ATP levels at local stimulated 
      points. We have also demonstrated that acupuncture could activate monocytes and 
      increase the expression of BDNF via the stimulation of ATP. The purpose of this 
      article is to review the recent findings and ongoing studies on the 
      neuroprotective roles of acupuncture and therapeutic implications of 
      acupuncture-induced activation of BDNF and its signaling pathway.
FAU - Lin, Dong
AU  - Lin D
AD  - College of acupuncture, Fujian University of Traditional Chinese Medicine, Minhou 
      Shangjie, Fuzhou 350122, Fujian, China. bluelike1@sina.com.
FAU - De La Pena, Ike
AU  - De La Pena I
AD  - Department of Neurosurgery and Brain Repair, College of Medicine, University of 
      South Florida, Tampa, FL 33612, USA. iked@health.usf.edu.
FAU - Lin, Lili
AU  - Lin L
AD  - College of acupuncture, Fujian University of Traditional Chinese Medicine, Minhou 
      Shangjie, Fuzhou 350122, Fujian, China. linlili77fz@163.com.
FAU - Zhou, Shu-Feng
AU  - Zhou SF
AD  - College of pharmacy, Department of pharmaceutical Sciences, University of South 
      Florida, Tampa, FL 33612, USA. szhou@health.usf.edu.
FAU - Borlongan, Cesar V
AU  - Borlongan CV
AD  - Department of Neurosurgery and Brain Repair, College of Medicine, University of 
      South Florida, Tampa, FL 33612, USA. cborlong@health.usf.edu.
FAU - Cao, Chuanhai
AU  - Cao C
AD  - College of pharmacy, Department of pharmaceutical Sciences, University of South 
      Florida, Tampa, FL 33612, USA. ccao@health.usf.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140221
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
SB  - IM
MH  - *Acupuncture Therapy
MH  - Adenosine Triphosphate/metabolism
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Humans
MH  - Neurons/*metabolism
MH  - Protein-Tyrosine Kinases/metabolism
MH  - *Signal Transduction
PMC - PMC3958908
EDAT- 2014/02/26 06:00
MHDA- 2015/03/31 06:00
PMCR- 2014/02/01
CRDT- 2014/02/26 06:00
PHST- 2013/11/28 00:00 [received]
PHST- 2014/02/08 00:00 [revised]
PHST- 2014/02/10 00:00 [accepted]
PHST- 2014/02/26 06:00 [entrez]
PHST- 2014/02/26 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
PHST- 2014/02/01 00:00 [pmc-release]
AID - ijms15023234 [pii]
AID - ijms-15-03234 [pii]
AID - 10.3390/ijms15023234 [doi]
PST - epublish
SO  - Int J Mol Sci. 2014 Feb 21;15(2):3234-52. doi: 10.3390/ijms15023234.