PMID- 2456634
OWN - NLM
STAT- MEDLINE
DCOM- 19880901
LR  - 20221007
IS  - 0300-8916 (Print)
IS  - 0300-8916 (Linking)
VI  - 74
IP  - 3
DP  - 1988 Jun 30
TI  - Morphologic and antigenic properties of mouse mammary tumor virus produced in a 
      hormone-responsive fashion by C57Bl/10 mammary tumors of non-viral origin.
PG  - 261-7
AB  - Bl-MaTU/A1 mouse mammary tumor cells, derived from a C57B1/10 mammary 
      adenocarcinoma induced by dimethylbenzanthracene and mammotropic hormones, 
      express virus particles and proteins related to mouse mammary tumor virus (MMTV). 
      Immunocytochemical analysis by means of monospecific and monoclonal anti-gp52 
      sera revealed a different localization of the main structural proteins of MMTV in 
      Bl-MaTU/A1 and GR cells (the latter used as a positive virus-producing control). 
      Immunoelectron microscopy of B-type particles budding from the microvilli of 
      dexamethasone-stimulated Bl-MaTU/A1 cells showed remarkably weak reactivity of 
      the viral envelope with anti-gp52-protein A-gold complexes as compared with that 
      of dexamethasone-stimulated GR cells. Since Bl-MaTU/A1-associated MMTV originates 
      from the amplified unit II of endogenous MMTV, which is altered probably within 
      the env gene, the observed antigenic difference in the Bl-MaTU/A1-associated MMTV 
      may be due to altered synthesis of gp52 glycoprotein in these cells.
FAU - Marchetti, A
AU  - Marchetti A
AD  - Institute of Pathologic Anatomy and Histology, University of Pisa, Italia.
FAU - Svec, J
AU  - Svec J
FAU - Hlavay, E
AU  - Hlavay E
FAU - Veselovska, Z
AU  - Veselovska Z
FAU - Castagna, M
AU  - Castagna M
FAU - Squartini, F
AU  - Squartini F
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Tumori
JT  - Tumori
JID - 0111356
RN  - 0 (Antigens, Viral, Tumor)
RN  - 0 (Epitopes)
SB  - IM
MH  - Adenocarcinoma/chemically induced/*microbiology
MH  - Animals
MH  - Antigens, Viral, Tumor/*immunology
MH  - Epitopes
MH  - Fluorescent Antibody Technique
MH  - In Vitro Techniques
MH  - Mammary Neoplasms, Experimental/chemically induced/*microbiology
MH  - Mammary Tumor Virus, Mouse/*immunology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Tumor Cells, Cultured/immunology
MH  - Virion/immunology
EDAT- 1988/06/30 00:00
MHDA- 1988/06/30 00:01
CRDT- 1988/06/30 00:00
PHST- 1988/06/30 00:00 [pubmed]
PHST- 1988/06/30 00:01 [medline]
PHST- 1988/06/30 00:00 [entrez]
AID - 10.1177/030089168807400304 [doi]
PST - ppublish
SO  - Tumori. 1988 Jun 30;74(3):261-7. doi: 10.1177/030089168807400304.