PMID- 24566686
OWN - NLM
STAT- MEDLINE
DCOM- 20150213
LR  - 20221207
IS  - 1573-4978 (Electronic)
IS  - 0301-4851 (Linking)
VI  - 41
IP  - 6
DP  - 2014 Jun
TI  - Human leukocyte antigen (HLA)-C polymorphisms are associated with a decreased 
      risk of rheumatoid arthritis.
PG  - 4103-8
LID - 10.1007/s11033-014-3280-9 [doi]
AB  - Rheumatoid arthritis (RA) is an autoimmune rheumatological disease thought to 
      have substantial genetic contributions. Several genetic factors involved in the 
      susceptibility to psoriasis and psoriatic arthritis (PsA) have been identified 
      with genome-wide association studies, including human leukocyte antigen (HLA)-C, 
      junction adhesion molecule 2 (JAM2) and REL. Psoriasis and PsA may share many 
      features in common with RA. We hypothesized that this polymorphism may contribute 
      to RA susceptibility in a Chinese population. We studied HLA-C rs10484554 C/T, 
      HLA-C rs12212594 T/C, HLA-C rs12191877 C/T, JAM2 rs2829866 A/T and REL rs702873 
      G/A polymorphisms in 520 patients with RA and 520 controls in a Chinese 
      population. HLA-C rs12191877 C/T polymorphism was in complete linkage 
      disequilibrium (LD) (D' = 1.0, r (2) = 1.0) with HLA-C rs10484554 C/T 
      polymorphism. When the HLA-C rs10484554 CC homozygote genotype was used as the 
      reference group, the TT/CT genotypes were associated with a significantly 
      decreased risk for RA (adjusted OR = 0.72, 95% CI = 0.52-0.99, p = 0.044). We 
      found that the HLA-C rs12191877 C/T polymorphism was also associated with a 
      decreased risk of RA. HLA-C rs12212594 T/C, JAM2 rs2829866 A/T and REL rs702873 
      G/A polymorphisms were not associated with the risk of RA. These results provide 
      evidence that HLA-C polymorphisms are associated with a decreased risk of RA.
FAU - Zhang, Yiqun
AU  - Zhang Y
AD  - Department of Ophthalmology, Affiliated Hospital of Suzhou University, Changzhou 
      No. 4 People's Hospital, Changzhou, 213001, China.
FAU - Zhang, Hui
AU  - Zhang H
FAU - Huang, Yong
AU  - Huang Y
FAU - Sun, Rongbin
AU  - Sun R
FAU - Liu, Ruiping
AU  - Liu R
FAU - Wei, Jie
AU  - Wei J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140225
PL  - Netherlands
TA  - Mol Biol Rep
JT  - Molecular biology reports
JID - 0403234
RN  - 0 (HLA-C Antigens)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Arthritis, Rheumatoid/*genetics/pathology
MH  - Asian People
MH  - Case-Control Studies
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - HLA-C Antigens/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Psoriasis/*genetics
EDAT- 2014/02/26 06:00
MHDA- 2015/02/14 06:00
CRDT- 2014/02/26 06:00
PHST- 2013/02/10 00:00 [received]
PHST- 2014/02/13 00:00 [accepted]
PHST- 2014/02/26 06:00 [entrez]
PHST- 2014/02/26 06:00 [pubmed]
PHST- 2015/02/14 06:00 [medline]
AID - 10.1007/s11033-014-3280-9 [doi]
PST - ppublish
SO  - Mol Biol Rep. 2014 Jun;41(6):4103-8. doi: 10.1007/s11033-014-3280-9. Epub 2014 
      Feb 25.