PMID- 24566726
OWN - NLM
STAT- MEDLINE
DCOM- 20141021
LR  - 20140226
IS  - 1791-3004 (Electronic)
IS  - 1791-2997 (Linking)
VI  - 9
IP  - 4
DP  - 2014 Apr
TI  - Expression of beta-amyloid precursor protein in refractory epilepsy.
PG  - 1242-8
LID - 10.3892/mmr.2014.1977 [doi]
AB  - beta-amyloid precursor protein (beta-APP), also known as Abeta peptide, has a key role in 
      the pathogenesis of Alzheimer's disease, and is also likely to be involved in the 
      development of refractory epilepsy. The mechanism behind the association between 
      beta-APP and refractory epilepsy remains to be elucidated. The aim of the present 
      study was to examine the levels of APP mRNA and beta-APP protein in patients with 
      refractory epilepsy. Tissue samples were obtained from patients with chronic 
      pharmacoresistant epilepsy who underwent surgery. Levels of APP mRNA and beta-APP 
      protein in epileptic temporal lobe and hippocampal tissue were assessed using 
      quantitative polymerase chain reaction, immunohistochemistry and 
      immunofluorescence. The expression levels of protein significantly increased in 
      the temporal cortex and the hippocampus of the patients with epilepsy. beta-APP may 
      thus contribute to the pathogenesis of refractory epilepsy.
FAU - Sima, Xiutian
AU  - Sima X
AD  - Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, 
      Sichuan 610041, P.R. China.
FAU - Xu, Jianguo
AU  - Xu J
AD  - Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, 
      Sichuan 610041, P.R. China.
FAU - Li, Jinmei
AU  - Li J
AD  - Department of Neurology, West China Hospital of Sichuan University, Chengdu, 
      Sichuan 610041, P.R. China.
FAU - Zhong, Weiying
AU  - Zhong W
AD  - Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, 
      Sichuan 610041, P.R. China.
FAU - You, Chao
AU  - You C
AD  - Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, 
      Sichuan 610041, P.R. China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140221
PL  - Greece
TA  - Mol Med Rep
JT  - Molecular medicine reports
JID - 101475259
RN  - 0 (Amyloid beta-Protein Precursor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Amyloid beta-Protein Precursor/*metabolism
MH  - Case-Control Studies
MH  - Epilepsy/*metabolism/*pathology
MH  - Female
MH  - Fluorescent Antibody Technique
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Young Adult
EDAT- 2014/02/26 06:00
MHDA- 2014/10/22 06:00
CRDT- 2014/02/26 06:00
PHST- 2013/06/13 00:00 [received]
PHST- 2014/02/05 00:00 [accepted]
PHST- 2014/02/26 06:00 [entrez]
PHST- 2014/02/26 06:00 [pubmed]
PHST- 2014/10/22 06:00 [medline]
AID - 10.3892/mmr.2014.1977 [doi]
PST - ppublish
SO  - Mol Med Rep. 2014 Apr;9(4):1242-8. doi: 10.3892/mmr.2014.1977. Epub 2014 Feb 21.