PMID- 24567226
OWN - NLM
STAT- MEDLINE
DCOM- 20140908
LR  - 20211021
IS  - 1364-6753 (Electronic)
IS  - 1364-6745 (Linking)
VI  - 15
IP  - 1
DP  - 2014 Mar
TI  - Brain-derived neurotrophic factor: its impact upon neuroplasticity and 
      neuroplasticity inducing transcranial brain stimulation protocols.
PG  - 1-11
LID - 10.1007/s10048-014-0393-1 [doi]
AB  - Val66Met (rs6265) is a gene variation, a single nucleotide polymorphism (SNP) in 
      the brain-derived neurotrophic factor (BDNF) gene that codes for the protein 
      BDNF. The substitution of Met for Val occurs at position 66 in the pro-region of 
      the BDNF gene and is responsible for altered activity-dependent release and 
      recruitment of BDNF in neurons. This is believed to manifest itself in an altered 
      ability in neuroplasticity induction and an increased predisposition toward a 
      number of neurological disorders. Many studies using neuroplasticity-inducing 
      protocols have investigated the impact of the BDNF polymorphism on cortical 
      modulation and plasticity; however, the results are partly contradictory and 
      dependent on the paradigm used in a given study. The aim of this review is to 
      summarize recent knowledge on the relationship of this BDNF SNP and 
      neuroplasticity.
FAU - Chaieb, L
AU  - Chaieb L
AD  - Clinic for Clinical Neurophysiology, University Medical Center, Georg-August 
      University, Robert-Koch-Str. 40, 37075, Gottingen, Germany.
FAU - Antal, A
AU  - Antal A
FAU - Ambrus, G G
AU  - Ambrus GG
FAU - Paulus, W
AU  - Paulus W
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140225
PL  - United States
TA  - Neurogenetics
JT  - Neurogenetics
JID - 9709714
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Animals
MH  - Brain/metabolism
MH  - Brain-Derived Neurotrophic Factor/*physiology
MH  - Central Nervous System/metabolism
MH  - *Gene Expression Profiling
MH  - *Gene Expression Regulation
MH  - Homozygote
MH  - Humans
MH  - Learning
MH  - Memory
MH  - Methionine/chemistry
MH  - Neuronal Plasticity
MH  - Neurons/*metabolism
MH  - Polymorphism, Single Nucleotide
MH  - Synapses/physiology
MH  - Transcranial Magnetic Stimulation/*methods
MH  - Valine/chemistry
EDAT- 2014/02/26 06:00
MHDA- 2014/09/10 06:00
CRDT- 2014/02/26 06:00
PHST- 2014/01/07 00:00 [received]
PHST- 2014/02/07 00:00 [accepted]
PHST- 2014/02/26 06:00 [entrez]
PHST- 2014/02/26 06:00 [pubmed]
PHST- 2014/09/10 06:00 [medline]
AID - 10.1007/s10048-014-0393-1 [doi]
PST - ppublish
SO  - Neurogenetics. 2014 Mar;15(1):1-11. doi: 10.1007/s10048-014-0393-1. Epub 2014 Feb 
      25.