PMID- 24568868
OWN - NLM
STAT- MEDLINE
DCOM- 20140708
LR  - 20211021
IS  - 1468-2079 (Electronic)
IS  - 0007-1161 (Print)
IS  - 0007-1161 (Linking)
VI  - 98 Suppl 1
IP  - Suppl 1
DP  - 2014 Jun
TI  - Pathology detection rate of spectral domain optical coherence tomography devices.
PG  - i3-6
LID - 10.1136/bjophthalmol-2013-303846 [doi]
AB  - BACKGROUND: Spectral domain optical coherence tomography (SDOCT) allows for 
      higher resolution scans and higher scanning speeds compared to time domain OCT 
      (TDOCT). The purpose of this study is to compare the pathology detection rates of 
      various SDOCT devices to the Stratus TDOCT. METHODS: Patients with neovascular 
      age-related macular degeneration were imaged on the Stratus and one of four SDOCT 
      devices. The images were then analysed in a masked manner evaluating for the 
      presence of epiretinal membrane (ERM), pigment epithelial detachment (PED) and 
      subretinal fluid (SRF). After determining that low scan density with one of the 
      devices was likely the cause of missed PED and SRF compared to the other SDOCT 
      devices the study was repeated with a higher scan density. RESULTS: 60 eyes from 
      60 patients with neovascular macular degeneration were imaged on each SDOCT 
      device, for a total of 240 eyes from 240 patients imaged on Stratus. There were 
      no instances where pathology was visible on Stratus but was missed on SDOCT. The 
      highest incidence of missed pathology was with SRF, followed by ERM and PED. 
      CONCLUSIONS: The increased resolution and image quality of SDOCT devices over 
      TDOCT allows for finer discrimination of retinal structures. The increased speed 
      of SDOCT allows for dense coverage of the macula resulting in the ability to see 
      smaller areas of PED and SRF. There was a critical threshold for the distance 
      between B-scans in the three-dimensional cube scan for detection of pathology.
CI  - Published by the BMJ Publishing Group Limited. For permission to use (where not 
      already granted under a licence) please go to 
      http://group.bmj.com/group/rights-licensing/permissions.
FAU - Sharma, Sumit
AU  - Sharma S
AD  - Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, USA.
FAU - Sayanagi, Kaori
AU  - Sayanagi K
AD  - Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, USA.
FAU - Kaiser, Peter K
AU  - Kaiser PK
AD  - Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140225
PL  - England
TA  - Br J Ophthalmol
JT  - The British journal of ophthalmology
JID - 0421041
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Equipment Design
MH  - Female
MH  - Humans
MH  - *Image Processing, Computer-Assisted
MH  - Macula Lutea/*pathology
MH  - Macular Degeneration/*diagnosis
MH  - Male
MH  - Reproducibility of Results
MH  - Tomography, Optical Coherence/*instrumentation
PMC - PMC4033177
OTO - NOTNLM
OT  - Imaging
OT  - Macula
OT  - Retina
EDAT- 2014/02/27 06:00
MHDA- 2014/07/09 06:00
CRDT- 2014/02/27 06:00
PHST- 2014/02/27 06:00 [entrez]
PHST- 2014/02/27 06:00 [pubmed]
PHST- 2014/07/09 06:00 [medline]
AID - bjophthalmol-2013-303846 [pii]
AID - 10.1136/bjophthalmol-2013-303846 [doi]
PST - ppublish
SO  - Br J Ophthalmol. 2014 Jun;98 Suppl 1(Suppl 1):i3-6. doi: 
      10.1136/bjophthalmol-2013-303846. Epub 2014 Feb 25.