PMID- 24571476
OWN - NLM
STAT- MEDLINE
DCOM- 20141024
LR  - 20211021
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 83
IP  - 3
DP  - 2014 Mar
TI  - Identification of 2127 new HLA class I alleles in potential stem cell donors from 
      Germany, the United States and Poland.
PG  - 184-9
LID - 10.1111/tan.12304 [doi]
AB  - We describe 2127 new human leukocyte antigen (HLA) class I alleles found in 
      registered stem cell donors. These alleles represent 28.9% of the currently known 
      class I alleles. Comparing new allele sequences to homologous sequences, we found 
      68.1% nonsynonymous nucleotide substitutions, 28.9% silent mutations and 3.0% 
      nonsense mutations. Many substitutions occurred at positions that have not been 
      known to be polymorphic before. A large number of HLA alleles and nucleotide 
      variations underline the extreme diversity of the HLA system. Strikingly, 156 new 
      alleles were found not only multiple times, but also in carriers of various 
      parentage, suggesting that some new alleles are not necessarily rare. Moreover, 
      new alleles were found especially often in minority donors. This emphasizes the 
      benefits of specifically recruiting such groups of individuals.
CI  - (c) 2014 The Authors. Tissue Antigens published by John Wiley & Sons Ltd.
FAU - Hernandez-Frederick, C J
AU  - Hernandez-Frederick CJ
AD  - DKMS German Bone Marrow Donor Center, Tubingen, Germany.
FAU - Giani, A S
AU  - Giani AS
FAU - Cereb, N
AU  - Cereb N
FAU - Sauter, J
AU  - Sauter J
FAU - Silva-Gonzalez, R
AU  - Silva-Gonzalez R
FAU - Pingel, J
AU  - Pingel J
FAU - Schmidt, A H
AU  - Schmidt AH
FAU - Ehninger, G
AU  - Ehninger G
FAU - Yang, S Y
AU  - Yang SY
LA  - eng
PT  - Journal Article
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (Codon)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Nucleotides)
SB  - IM
MH  - *Alleles
MH  - Base Sequence
MH  - Codon/genetics
MH  - Exons/genetics
MH  - Genetic Loci
MH  - Germany
MH  - Haplotypes/genetics
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Mutation/genetics
MH  - Nucleotides/genetics
MH  - Poland
MH  - Registries
MH  - Stem Cells/*metabolism
MH  - *Tissue Donors
MH  - United States
PMC - PMC4199310
OTO - NOTNLM
OT  - genetic diversity
OT  - hematopoietic stem cell transplantation
OT  - human leukocyte antigens
OT  - new alleles
OT  - sequencing-based typing
EDAT- 2014/02/28 06:00
MHDA- 2014/10/25 06:00
CRDT- 2014/02/28 06:00
PHST- 2013/10/11 00:00 [received]
PHST- 2014/01/13 00:00 [revised]
PHST- 2014/01/13 00:00 [accepted]
PHST- 2014/02/28 06:00 [entrez]
PHST- 2014/02/28 06:00 [pubmed]
PHST- 2014/10/25 06:00 [medline]
AID - 10.1111/tan.12304 [doi]
PST - ppublish
SO  - Tissue Antigens. 2014 Mar;83(3):184-9. doi: 10.1111/tan.12304.