PMID- 24572097
OWN - NLM
STAT- MEDLINE
DCOM- 20141231
LR  - 20191210
IS  - 1522-1598 (Electronic)
IS  - 0022-3077 (Linking)
VI  - 111
IP  - 10
DP  - 2014 May
TI  - BDNF Val66Met polymorphism is associated with abnormal interhemispheric transfer 
      of a newly acquired motor skill.
PG  - 2094-102
LID - 10.1152/jn.00388.2013 [doi]
AB  - Recent data suggest that the Val66Met polymorphism of the brain-derived 
      neurotrophic factor (BDNF) gene can alter cortical plasticity within the motor 
      cortex of carriers, which exhibits abnormally low rates of cortical 
      reorganization after repetitive motor tasks. To verify whether long-term 
      retention of a motor skill is also modulated by the presence of the polymorphism, 
      20 participants (10 Val66Val, 10 Val66Met) were tested twice at a 1-wk interval. 
      During each visit, excitability of the motor cortex was measured by transcranial 
      magnetic stimulations (TMS) before and after performance of a procedural motor 
      learning task (serial reaction time task) designed to study sequence-specific 
      learning of the right hand and sequence-specific transfer from the right to the 
      left hand. Behavioral results showed a motor learning effect that persisted for 
      at least a week and task-related increases in corticospinal excitability 
      identical for both sessions and without distinction for genetic group. 
      Sequence-specific transfer of the motor skill from the right hand to the left 
      hand was greater in session 2 than in session 1 only in the Val66Met genetic 
      group. Further analysis revealed that the sequence-specific transfer occurred 
      equally at both sessions in the Val66Val genotype group. In the Val66Met genotype 
      group, sequence-specific transfer did not occur at session 1 but did at session 
      2. These data suggest a limited impact of Val66Met polymorphism on the learning 
      and retention of a complex motor skill and its associated changes in 
      corticospinal excitability over time, and a possible modulation of the 
      interhemispheric transfer of procedural learning.
CI  - Copyright (c) 2014 the American Physiological Society.
FAU - Morin-Moncet, Olivier
AU  - Morin-Moncet O
AD  - Universite de Montreal, Montreal, Quebec, Canada;
FAU - Beaumont, Vincent
AU  - Beaumont V
AD  - Universite de Montreal, Montreal, Quebec, Canada;
FAU - de Beaumont, Louis
AU  - de Beaumont L
AD  - Universite du Quebec a Trois-Rivieres, Montreal, Quebec, Canada; and.
FAU - Lepage, Jean-Francois
AU  - Lepage JF
AD  - Universite de Montreal, Montreal, Quebec, Canada;
FAU - Theoret, Hugo
AU  - Theoret H
AD  - Universite de Montreal, Montreal, Quebec, Canada; Hopital Sainte-Justine Research 
      Center, Montreal, Quebec, Canada hugo.theoret@umontreal.ca.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140226
PL  - United States
TA  - J Neurophysiol
JT  - Journal of neurophysiology
JID - 0375404
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - Functional Laterality/physiology
MH  - Genotype
MH  - Genotyping Techniques
MH  - Hand/physiology
MH  - Humans
MH  - Learning/*physiology
MH  - Male
MH  - Motor Cortex/*physiology
MH  - Motor Skills/*physiology
MH  - Muscle, Skeletal/physiology
MH  - Neuropsychological Tests
MH  - *Polymorphism, Single Nucleotide
MH  - Pyramidal Tracts/physiology
MH  - Reaction Time
MH  - Task Performance and Analysis
MH  - Time Factors
MH  - Transcranial Magnetic Stimulation
MH  - Transfer, Psychology/*physiology
MH  - Young Adult
OTO - NOTNLM
OT  - brain-derived neurotrophic factor
OT  - interhemispheric transfer
OT  - motor learning
OT  - serial reaction time task
OT  - transcranial magnetic stimulation
EDAT- 2014/02/28 06:00
MHDA- 2015/01/01 06:00
CRDT- 2014/02/28 06:00
PHST- 2014/02/28 06:00 [entrez]
PHST- 2014/02/28 06:00 [pubmed]
PHST- 2015/01/01 06:00 [medline]
AID - jn.00388.2013 [pii]
AID - 10.1152/jn.00388.2013 [doi]
PST - ppublish
SO  - J Neurophysiol. 2014 May;111(10):2094-102. doi: 10.1152/jn.00388.2013. Epub 2014 
      Feb 26.