PMID- 24573984
OWN - NLM
STAT- MEDLINE
DCOM- 20150413
LR  - 20211021
IS  - 1865-3774 (Electronic)
IS  - 0925-5710 (Linking)
VI  - 99
IP  - 5
DP  - 2014
TI  - Identification of predictive factors for response to intravenous immunoglobulin 
      treatment in children with immune thrombocytopenia.
PG  - 597-602
LID - 10.1007/s12185-014-1551-9 [doi]
AB  - Acute immune thrombocytopenia (ITP) is a common benign bleeding disorder of 
      variable etiology characterized by isolated thrombocytopenia. Intravenous 
      immunoglobulin (IVIG) treatment is generally given as an initial treatment to 
      pediatric patients with ITP, but markers predictive of the response to IVIG 
      remain poorly defined. We retrospectively evaluated whether clinical and 
      laboratory findings before treatment could predict response to IVIG and 
      progression to chronic ITP in Japanese children with ITP. Between April 1997 and 
      December 2011, a total of 49 children with newly diagnosed ITP were initially 
      treated with IVIG. Their medical records were retrospectively reviewed. In 
      multivariate analyses, lower white blood cell (WBC) count was the only 
      unfavorable factor for response to IVIG and progression to chronic ITP. Patients 
      with WBC count <7.0 x 10(9)/L had a lower probability of thrombocytopenia-free 
      survival (41 vs. 77 %, P = 0.003) and a higher rate of progression to chronic ITP 
      (29 vs. 6 %, P = 0.040) than those with WBC count >/=7.0 x 10(9)/L. These results 
      suggest that ITP with lower WBC count may represent a distinct subgroup requiring 
      initial treatment other than IVIG.
FAU - Morimoto, Yoshihito
AU  - Morimoto Y
AD  - Department of Hematology and Oncology, Children's Medical Center, Japanese Red 
      Cross Nagoya First Hospital, 3-35 Michishita-cho, Nakamura-ku, Nagoya, 453-8511, 
      Japan.
FAU - Yoshida, Nao
AU  - Yoshida N
FAU - Kawashima, Nozomu
AU  - Kawashima N
FAU - Matsumoto, Kimikazu
AU  - Matsumoto K
FAU - Kato, Koji
AU  - Kato K
LA  - eng
PT  - Journal Article
DEP - 20140227
PL  - Japan
TA  - Int J Hematol
JT  - International journal of hematology
JID - 9111627
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Immunoglobulins, Intravenous/administration & dosage/*therapeutic use
MH  - Infant
MH  - Infant, Newborn
MH  - Leukocyte Count
MH  - Male
MH  - Platelet Count
MH  - Prognosis
MH  - Purpura, Thrombocytopenic, Idiopathic/diagnosis/*drug therapy/mortality
MH  - Risk Factors
MH  - Treatment Outcome
EDAT- 2014/02/28 06:00
MHDA- 2015/04/14 06:00
CRDT- 2014/02/28 06:00
PHST- 2013/09/17 00:00 [received]
PHST- 2014/02/18 00:00 [accepted]
PHST- 2014/02/17 00:00 [revised]
PHST- 2014/02/28 06:00 [entrez]
PHST- 2014/02/28 06:00 [pubmed]
PHST- 2015/04/14 06:00 [medline]
AID - 10.1007/s12185-014-1551-9 [doi]
PST - ppublish
SO  - Int J Hematol. 2014;99(5):597-602. doi: 10.1007/s12185-014-1551-9. Epub 2014 Feb 
      27.