PMID- 24574351
OWN - NLM
STAT- MEDLINE
DCOM- 20150429
LR  - 20181202
IS  - 1935-5548 (Electronic)
IS  - 0149-5992 (Linking)
VI  - 37
IP  - 5
DP  - 2014 May
TI  - Systolic and diastolic abnormalities reduce the cardiac response to exercise in 
      adolescents with type 2 diabetes.
PG  - 1439-46
LID - 10.2337/dc13-2031 [doi]
AB  - OBJECTIVE: To better understand the cardiac limitations during exercise in 
      adolescents with type 2 diabetes mellitus (T2DM), we measured left ventricular 
      performance with magnetic resonance imaging (MRI) during exercise in diabetic and 
      nondiabetic adolescents. RESEARCH DESIGN AND METHODS: Thirteen subjects with 
      T2DM, 27 overweight/obese nondiabetic (ObeseND) subjects, and 19 nondiabetic 
      nonobese control subjects were recruited. Cardiac (left ventricular) MRI scans 
      were performed at rest and during submaximal exercise. RESULTS: Vo2 peak indexed 
      to fat-free mass was reduced in T2DM and ObeseND subjects compared with control 
      subjects (P < 0.0001). Indexed cardiac output increased less during exercise and 
      was 20% lower in T2DM subjects due to reduced stroke volume. This was a 
      consequence of reduced ventricular filling with smaller end-diastolic volume, 
      which decreased further during exercise in T2DM subjects, but not in ObeseND or 
      control subjects. End-systolic volume was also smaller in T2DM subjects. These 
      changes were associated with increased resting and exercise diastolic blood 
      pressure, and total peripheral resistance in T2DM subjects. CONCLUSIONS: 
      Independently of obesity, T2DM impairs cardiac function during exercise in 
      adolescents.
FAU - Pinto, Teresa E
AU  - Pinto TE
AD  - Corresponding author: Paul L. Hofman, p.hofman@auckland.ac.nz.
FAU - Gusso, Silmara
AU  - Gusso S
FAU - Hofman, Paul L
AU  - Hofman PL
FAU - Derraik, Jose G B
AU  - Derraik JG
FAU - Hornung, Tim S
AU  - Hornung TS
FAU - Cutfield, Wayne S
AU  - Cutfield WS
FAU - Baldi, J Chris
AU  - Baldi JC
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140226
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
SB  - IM
MH  - Adolescent
MH  - Blood Pressure
MH  - Diabetes Mellitus, Type 2/*physiopathology
MH  - Diastole
MH  - *Exercise
MH  - Female
MH  - Heart/*physiopathology
MH  - Humans
MH  - Male
MH  - Obesity/physiopathology
MH  - Systole
MH  - Vascular Resistance
EDAT- 2014/02/28 06:00
MHDA- 2015/04/30 06:00
CRDT- 2014/02/28 06:00
PHST- 2014/02/28 06:00 [entrez]
PHST- 2014/02/28 06:00 [pubmed]
PHST- 2015/04/30 06:00 [medline]
AID - dc13-2031 [pii]
AID - 10.2337/dc13-2031 [doi]
PST - ppublish
SO  - Diabetes Care. 2014 May;37(5):1439-46. doi: 10.2337/dc13-2031. Epub 2014 Feb 26.