PMID- 24574779 OWN - NLM STAT- MEDLINE DCOM- 20141117 LR - 20220408 IS - 2219-2840 (Electronic) IS - 1007-9327 (Print) IS - 1007-9327 (Linking) VI - 20 IP - 4 DP - 2014 Jan 28 TI - Long-term pretreatment with proton pump inhibitor and Helicobacter pylori eradication rates. PG - 1061-6 LID - 10.3748/wjg.v20.i4.1061 [doi] AB - AIM: To investigate whether proton pump inhibitor (PPI) pretreatment influences Helicobacter pylori eradication rate. METHODS: We retrospectively reviewed H. pylori-infected patients who were treated with a standard triple regimen (PPI, amoxicillin 1 g, and clarithromycin 500 mg, all twice daily for 7 d). The diagnosis of H. pylori infection and its eradication was assessed with the rapid urease test, histological examination by silver staining, or the (1)(3)C-urea breath test. We divided the patients into two groups: one received the standard eradication regimen without PPI pretreatment (Group A), and the other received PPI pretreatment (Group B). The patients in Group B were reclassified into three groups based on the duration of PPI pretreatment: Group B-I (3-14 d), Group B-II (15-55 d), and Group B-III (>/= 56 d). RESULTS: A total of 1090 patients were analyzed and the overall eradication rate was 80.9%. The cure rate in Group B (81.2%, 420/517) was not significantly different from that in Group A (79.2%, 454/573). The eradication rates in Group B-I, B-II and B-III were 80.1% (117/146), 81.8% (224/274) and 81.4% (79/97), respectively. CONCLUSION: PPI pretreatment did not affect H. pylori eradication rate, regardless of the medication period. FAU - Yoon, Seung Bae AU - Yoon SB AD - Seung Bae Yoon, Jae Myung Park, Jong-Yul Lee, Myong Ki Baeg, Chul-Hyun Lim, Jin Soo Kim, Yu Kyung Cho, In Seok Lee, Sang Woo Kim, Myung-Gyu Choi, Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-856, South Korea. FAU - Park, Jae Myung AU - Park JM AD - Seung Bae Yoon, Jae Myung Park, Jong-Yul Lee, Myong Ki Baeg, Chul-Hyun Lim, Jin Soo Kim, Yu Kyung Cho, In Seok Lee, Sang Woo Kim, Myung-Gyu Choi, Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-856, South Korea. FAU - Lee, Jong-Yul AU - Lee JY AD - Seung Bae Yoon, Jae Myung Park, Jong-Yul Lee, Myong Ki Baeg, Chul-Hyun Lim, Jin Soo Kim, Yu Kyung Cho, In Seok Lee, Sang Woo Kim, Myung-Gyu Choi, Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-856, South Korea. FAU - Baeg, Myong Ki AU - Baeg MK AD - Seung Bae Yoon, Jae Myung Park, Jong-Yul Lee, Myong Ki Baeg, Chul-Hyun Lim, Jin Soo Kim, Yu Kyung Cho, In Seok Lee, Sang Woo Kim, Myung-Gyu Choi, Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-856, South Korea. FAU - Lim, Chul-Hyun AU - Lim CH AD - Seung Bae Yoon, Jae Myung Park, Jong-Yul Lee, Myong Ki Baeg, Chul-Hyun Lim, Jin Soo Kim, Yu Kyung Cho, In Seok Lee, Sang Woo Kim, Myung-Gyu Choi, Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-856, South Korea. FAU - Kim, Jin Soo AU - Kim JS AD - Seung Bae Yoon, Jae Myung Park, Jong-Yul Lee, Myong Ki Baeg, Chul-Hyun Lim, Jin Soo Kim, Yu Kyung Cho, In Seok Lee, Sang Woo Kim, Myung-Gyu Choi, Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-856, South Korea. FAU - Cho, Yu Kyung AU - Cho YK AD - Seung Bae Yoon, Jae Myung Park, Jong-Yul Lee, Myong Ki Baeg, Chul-Hyun Lim, Jin Soo Kim, Yu Kyung Cho, In Seok Lee, Sang Woo Kim, Myung-Gyu Choi, Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-856, South Korea. FAU - Lee, In Seok AU - Lee IS AD - Seung Bae Yoon, Jae Myung Park, Jong-Yul Lee, Myong Ki Baeg, Chul-Hyun Lim, Jin Soo Kim, Yu Kyung Cho, In Seok Lee, Sang Woo Kim, Myung-Gyu Choi, Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-856, South Korea. FAU - Kim, Sang Woo AU - Kim SW AD - Seung Bae Yoon, Jae Myung Park, Jong-Yul Lee, Myong Ki Baeg, Chul-Hyun Lim, Jin Soo Kim, Yu Kyung Cho, In Seok Lee, Sang Woo Kim, Myung-Gyu Choi, Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-856, South Korea. FAU - Choi, Myung-Gyu AU - Choi MG AD - Seung Bae Yoon, Jae Myung Park, Jong-Yul Lee, Myong Ki Baeg, Chul-Hyun Lim, Jin Soo Kim, Yu Kyung Cho, In Seok Lee, Sang Woo Kim, Myung-Gyu Choi, Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-856, South Korea. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - World J Gastroenterol JT - World journal of gastroenterology JID - 100883448 RN - 0 (Anti-Bacterial Agents) RN - 0 (Proton Pump Inhibitors) SB - IM MH - Adult MH - Anti-Bacterial Agents/*administration & dosage MH - Drug Administration Schedule MH - Drug Therapy, Combination MH - Female MH - Helicobacter Infections/diagnosis/*drug therapy/microbiology MH - Helicobacter pylori/*drug effects/pathogenicity MH - Humans MH - Male MH - Middle Aged MH - Proton Pump Inhibitors/*administration & dosage MH - Retrospective Studies MH - Time Factors MH - Treatment Outcome PMC - PMC3921530 OTO - NOTNLM OT - Antibiotics OT - Drug resistance OT - Helicobacter pylori OT - Proton pump inhibitor OT - Urea breath test EDAT- 2014/02/28 06:00 MHDA- 2014/11/18 06:00 PMCR- 2014/01/28 CRDT- 2014/02/28 06:00 PHST- 2013/08/12 00:00 [received] PHST- 2013/09/20 00:00 [revised] PHST- 2013/12/13 00:00 [accepted] PHST- 2014/02/28 06:00 [entrez] PHST- 2014/02/28 06:00 [pubmed] PHST- 2014/11/18 06:00 [medline] PHST- 2014/01/28 00:00 [pmc-release] AID - 10.3748/wjg.v20.i4.1061 [doi] PST - ppublish SO - World J Gastroenterol. 2014 Jan 28;20(4):1061-6. doi: 10.3748/wjg.v20.i4.1061.