PMID- 24574831
OWN - NLM
STAT- MEDLINE
DCOM- 20150402
LR  - 20211021
IS  - 2005-6648 (Electronic)
IS  - 1226-3303 (Print)
IS  - 1226-3303 (Linking)
VI  - 29
IP  - 1
DP  - 2014 Jan
TI  - Measurement of antioxidant capacity using the biological antioxidant potential 
      test and its role as a predictive marker of metabolic syndrome.
PG  - 31-9
LID - 10.3904/kjim.2014.29.1.31 [doi]
AB  - BACKGROUND/AIMS: Oxidative stress increases the risk of cardiovascular 
      complications of metabolic syndrome (MetS). This study was conducted to examine 
      the difference in antioxidant capacity according to the presence of MetS, and to 
      characterize the association between antioxidant capacity and MetS-related 
      factors. METHODS: We used the biological antioxidant potential (BAP) test to 
      estimate antioxidant capacity. The BAP test has recently been used as an 
      indicator of antioxidant capacity. We measured BAP levels in 45 patients with 
      MetS (mean age, 44.6 +/- 1.1 years) and 47 age- and sex-matched controls (mean age, 
      42.7 +/- 1.1 years). To evaluate the association between antioxidant capacity and 
      MetS, adiponectin, high-sensitivity C-reactive protein (hs-CRP), interleukin-6, 
      tumor necrosis factor-alpha, and homeostatic model assessment for insulin resistance 
      (HOMA-IR), linear regression and logistic analyses were performed. RESULTS: The 
      mean BAP of the MetS group (1,937.3 +/- 36.5 micromol/L) was significantly lower than 
      that of the non-MetS group (2,101.7 +/- 29.5 micromol/L). Also, the mean BAP was low in 
      persons having low high density lipoprotein and high triglyceride. Reduced 
      antioxidant capacity was significantly associated with adiponectin, HOMA-IR and 
      hs-CRP after adjusting for age and sex. The odds ratios for MetS with BAP, log 
      adiponectin, log HOMA-IR, and log hs-CRP were 0.63 (95% confidence interval [CI], 
      0.49 to 0.82), 0.22 (0.10 to 0.51), 14.24 (4.35 to 46.58), and 1.93 (1.36 to 
      2.75), respectively. CONCLUSIONS: Persons with MetS showed reduced antioxidant 
      capacity. We identified relationships between antioxidant capacity measured by 
      BAP test and MetS, as well as MetS-related factors, such as insulin resistance, 
      hs-CRP, and adiponectin.
FAU - Kim, Jung Hee
AU  - Kim JH
AD  - Department of Internal Medicine, Bundang Jesaeng Hospital, Seongnam, Korea.
FAU - Baik, Hyun Wook
AU  - Baik HW
AD  - Department of Internal Medicine, Bundang Jesaeng Hospital, Seongnam, Korea.
FAU - Yoon, Yeong Sook
AU  - Yoon YS
AD  - Department of Family Medicine, Inje University Ilsan Paik Hospital, Goyang, 
      Korea.
FAU - Joung, Hyo Jee
AU  - Joung HJ
AD  - Seoul National University Graduate School of Public Health, Seoul, Korea.
FAU - Park, Ju Sang
AU  - Park JS
AD  - Department of Internal Medicine, Bundang Jesaeng Hospital, Seongnam, Korea.
FAU - Park, Sang Jong
AU  - Park SJ
AD  - Department of Internal Medicine, Bundang Jesaeng Hospital, Seongnam, Korea.
FAU - Jang, Eun Jeong
AU  - Jang EJ
AD  - Department of Internal Medicine, Bundang Jesaeng Hospital, Seongnam, Korea.
FAU - Park, Sang Woon
AU  - Park SW
AD  - Department of Internal Medicine, Bundang Jesaeng Hospital, Seongnam, Korea.
FAU - Kim, Sang Jung
AU  - Kim SJ
AD  - Department of Internal Medicine, Bundang Jesaeng Hospital, Seongnam, Korea.
FAU - Kim, Mi Jeoung
AU  - Kim MJ
AD  - Department of Internal Medicine, Bundang Jesaeng Hospital, Seongnam, Korea.
FAU - Jeon, Dong Ok
AU  - Jeon DO
AD  - Department of Internal Medicine, Bundang Jesaeng Hospital, Seongnam, Korea.
FAU - Cho, Hyo Jin
AU  - Cho HJ
AD  - Department of Internal Medicine, Bundang Jesaeng Hospital, Seongnam, Korea.
FAU - Lee, Sang Jin
AU  - Lee SJ
AD  - Department of Internal Medicine, Bundang Jesaeng Hospital, Seongnam, Korea.
FAU - Im, Sung Gyu
AU  - Im SG
AD  - Department of Internal Medicine, Bundang Jesaeng Hospital, Seongnam, Korea.
FAU - Jang, Sun Kyung
AU  - Jang SK
AD  - Department of Internal Medicine, Bundang Jesaeng Hospital, Seongnam, Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140102
PL  - Korea (South)
TA  - Korean J Intern Med
JT  - The Korean journal of internal medicine
JID - 8712418
RN  - 0 (Adipokines)
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
CIN - Korean J Intern Med. 2014 Jan;29(1):20-2. PMID: 24574828
MH  - Adipokines/blood
MH  - Adult
MH  - Antioxidants/*metabolism
MH  - Biomarkers/blood
MH  - C-Reactive Protein/metabolism
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Insulin Resistance
MH  - Interleukin-6/blood
MH  - Male
MH  - Metabolic Syndrome/*blood
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Tumor Necrosis Factor-alpha/blood
PMC - PMC3932393
OTO - NOTNLM
OT  - Adiponectin
OT  - Insulin
OT  - Metabolic syndrome
OT  - Oxidative stress
COIS- No potential conflict of interest relevant to this article is reported.
EDAT- 2014/02/28 06:00
MHDA- 2015/04/04 06:00
PMCR- 2014/01/01
CRDT- 2014/02/28 06:00
PHST- 2012/08/10 00:00 [received]
PHST- 2012/11/07 00:00 [revised]
PHST- 2012/11/29 00:00 [accepted]
PHST- 2014/02/28 06:00 [entrez]
PHST- 2014/02/28 06:00 [pubmed]
PHST- 2015/04/04 06:00 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 10.3904/kjim.2014.29.1.31 [doi]
PST - ppublish
SO  - Korean J Intern Med. 2014 Jan;29(1):31-9. doi: 10.3904/kjim.2014.29.1.31. Epub 
      2014 Jan 2.