PMID- 24575414
OWN - NLM
STAT- MEDLINE
DCOM- 20141015
LR  - 20220318
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2014
DP  - 2014
TI  - Soluplus graft copolymer: potential novel carrier polymer in electrospinning of 
      nanofibrous drug delivery systems for wound therapy.
PG  - 789765
LID - 10.1155/2014/789765 [doi]
LID - 789765
AB  - Electrospinning is an effective method in preparing polymeric nanofibrous drug 
      delivery systems (DDSs) for topical wound healing and skin burn therapy 
      applications. The aim of the present study was to investigate a new synthetic 
      graft copolymer (Soluplus) as a hydrophilic carrier polymer in electrospinning of 
      nanofibrous DDSs. Soluplus (polyvinyl caprolactam-polyvinyl acetate-polyethylene 
      glycol graft copolymer (PCL-PVAc-PEG)) was applied in the nonwoven nanomats 
      loaded with piroxicam (PRX) as a poorly water-soluble drug. Raman spectroscopy, 
      X-ray powder diffraction, differential scanning calorimetry, and scanning 
      electron microscopy (SEM) were used in the physical characterization of 
      nanofibrous DDSs. According to the SEM results, the drug-loaded PCL-PVAc-PEG 
      nanofibers were circular in cross-section with an average diameter ranging from 
      500 nm up to 2  microm. Electrospinning stabilized the amorphous state of PRX. In 
      addition, consistent and sustained-release profile was achieved with the present 
      nanofibrous DDSs at the physiologically relevant temperature and pH applicable in 
      wound healing therapy. In conclusion, electrospinning can be used to prepare 
      nanofibrous DDSs of PCL-PVAc-PEG graft copolymer (Soluplus) and to stabilize the 
      amorphous state of a poorly water-soluble PRX. The use of this synthetic graft 
      copolymer can open new options to formulate nanofibrous DDSs for wound healing.
FAU - Paaver, Urve
AU  - Paaver U
AUID- ORCID: 0000-0003-2406-7675
AD  - Department of Pharmacy, Faculty of Medicine, University of Tartu, Nooruse 1, 
      50411 Tartu, Estonia.
FAU - Tamm, Ingrid
AU  - Tamm I
AD  - Department of Pharmacy, Faculty of Medicine, University of Tartu, Nooruse 1, 
      50411 Tartu, Estonia.
FAU - Laidmae, Ivo
AU  - Laidmae I
AD  - Department of Pharmacy, Faculty of Medicine, University of Tartu, Nooruse 1, 
      50411 Tartu, Estonia ; Immunology Group, Institute of Biomedicine and 
      Translational Medicine, Faculty of Medicine, University of Tartu, Ravila 19, 
      50411 Tartu, Estonia.
FAU - Lust, Andres
AU  - Lust A
AD  - Department of Pharmacy, Faculty of Medicine, University of Tartu, Nooruse 1, 
      50411 Tartu, Estonia.
FAU - Kirsimae, Kalle
AU  - Kirsimae K
AD  - Institute of Ecology and Earth Sciences, University of Tartu, Ravila 14a, 50411 
      Tartu, Estonia.
FAU - Veski, Peep
AU  - Veski P
AUID- ORCID: 0000-0001-7787-1232
AD  - Department of Pharmacy, Faculty of Medicine, University of Tartu, Nooruse 1, 
      50411 Tartu, Estonia.
FAU - Kogermann, Karin
AU  - Kogermann K
AUID- ORCID: 0000-0002-6813-4828
AD  - Department of Pharmacy, Faculty of Medicine, University of Tartu, Nooruse 1, 
      50411 Tartu, Estonia.
FAU - Heinamaki, Jyrki
AU  - Heinamaki J
AUID- ORCID: 0000-0002-5996-5144
AD  - Department of Pharmacy, Faculty of Medicine, University of Tartu, Nooruse 1, 
      50411 Tartu, Estonia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140120
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Polymers)
RN  - 0 (Polyvinyls)
RN  - 0 (polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer)
RN  - 059QF0KO0R (Water)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
SB  - IM
MH  - *Drug Delivery Systems
MH  - Humans
MH  - Microscopy, Electron, Scanning
MH  - Nanofibers/administration & dosage
MH  - Polyethylene Glycols/*administration & dosage
MH  - Polymers/administration & dosage
MH  - Polyvinyls/*administration & dosage
MH  - Water/chemistry
MH  - *Wound Healing
MH  - Wound Infection/*therapy
MH  - X-Ray Diffraction
PMC - PMC3918357
EDAT- 2014/02/28 06:00
MHDA- 2014/10/16 06:00
PMCR- 2014/01/20
CRDT- 2014/02/28 06:00
PHST- 2013/11/11 00:00 [received]
PHST- 2013/12/23 00:00 [revised]
PHST- 2013/12/23 00:00 [accepted]
PHST- 2014/02/28 06:00 [entrez]
PHST- 2014/02/28 06:00 [pubmed]
PHST- 2014/10/16 06:00 [medline]
PHST- 2014/01/20 00:00 [pmc-release]
AID - 10.1155/2014/789765 [doi]
PST - ppublish
SO  - Biomed Res Int. 2014;2014:789765. doi: 10.1155/2014/789765. Epub 2014 Jan 20.