PMID- 24576150
OWN - NLM
STAT- MEDLINE
DCOM- 20150324
LR  - 20211021
IS  - 1399-3038 (Electronic)
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 25
IP  - 4
DP  - 2014 Jun
TI  - Cord blood LC-PUFA composition and allergic diseases during the first 10 yr. 
      Results from the LISAplus study.
PG  - 344-50
LID - 10.1111/pai.12212 [doi]
AB  - BACKGROUND: It has been suggested that n-6 and n-3 long-chain polyunsaturated 
      fatty acids (LC-PUFAs) in blood are associated with risk of allergic diseases, 
      although results are inconclusive. Low levels of n-6 LC-PUFA and high levels of 
      n-3 LC-PUFA are anticipated to have beneficial effects. Pregnancy is considered a 
      critical time period for imprinting the developing immune system. We examined 
      whether n-6 LC-PUFA, n-3 LC-PUFA concentrations or the n-6/n-3 ratio in cord 
      blood (CB) serum are associated with allergic diseases up to the age of 10 yr. 
      METHODS: This analysis included 436 children from the Munich LISAplus birth 
      cohort study. Information on doctor-diagnosed asthma, hay fever/allergic 
      rhinitis, and eczema was collected using questionnaires completed at the ages 6 
      and 10 yr, and for eczema additionally at 2 yr. Specific immunoglobulin E (IgE) 
      against inhalant allergens was measured at 6 and 10 yr. Fatty acid composition 
      was measured by gas chromatography in serum from CB and from blood collected at 
      2, 6, and 10 yr. Associations between n-3, n-6 LC-PUFA concentrations, and the 
      n-6/n-3 ratio in CB serum and allergic diseases or atopy were assessed using 
      generalized estimating equations (GEE) considering the longitudinal structure. 
      Models were adjusted for LC-PUFA concentrations at follow-up and potential 
      confounding factors. RESULTS: There was no significant association between n-3 
      LC-PUFA, n-6 LC-PUFA, or the n-6/n-3 ratio in CB serum with eczema, asthma, hay 
      fever/allergic rhinitis, or aeroallergen sensitization. CONCLUSIONS: There is no 
      indication of a beneficial effect of increased n-3 LC-PUFA in CB serum on the 
      development of any of the disease entities.
CI  - (c) 2014 The Authors. Pediatric Allergy and Immunology Published by John Wiley & 
      Sons Ltd.
FAU - Standl, Marie
AU  - Standl M
AD  - Institute of Epidemiology I, Helmholtz Zentrum Munchen - German Research Centre 
      for Environmental Health, Neuherberg, Germany.
FAU - Demmelmair, Hans
AU  - Demmelmair H
FAU - Koletzko, Berthold
AU  - Koletzko B
FAU - Heinrich, Joachim
AU  - Heinrich J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140227
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Fatty Acids, Omega-3)
RN  - 0 (Fatty Acids, Omega-6)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Anaphylaxis/diagnosis/epidemiology/immunology
MH  - Child
MH  - Chromatography, Gas
MH  - Cohort Studies
MH  - Fatty Acids, Omega-3/*blood/chemistry
MH  - Fatty Acids, Omega-6/*blood/chemistry
MH  - Female
MH  - Fetal Blood/*immunology
MH  - Follow-Up Studies
MH  - Germany/epidemiology
MH  - Humans
MH  - Hypersensitivity/diagnosis/*epidemiology/immunology
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Pregnancy
PMC - PMC4238817
OTO - NOTNLM
OT  - allergies
OT  - asthma
OT  - atopy
OT  - children
OT  - cord blood
OT  - eczema
OT  - epidemiology
OT  - fatty acids
OT  - polyunsaturated fatty acids
OT  - rhinitis
EDAT- 2014/03/01 06:00
MHDA- 2015/03/25 06:00
PMCR- 2014/11/20
CRDT- 2014/03/01 06:00
PHST- 2014/01/31 00:00 [accepted]
PHST- 2014/03/01 06:00 [entrez]
PHST- 2014/03/01 06:00 [pubmed]
PHST- 2015/03/25 06:00 [medline]
PHST- 2014/11/20 00:00 [pmc-release]
AID - 10.1111/pai.12212 [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2014 Jun;25(4):344-50. doi: 10.1111/pai.12212. Epub 2014 
      Feb 27.