PMID- 24576320
OWN - NLM
STAT- MEDLINE
DCOM- 20141203
LR  - 20220331
IS  - 1398-9995 (Electronic)
IS  - 0105-4538 (Linking)
VI  - 69
IP  - 5
DP  - 2014 May
TI  - Multiplexed immunoglobulin E sensitization in relation to exhaled nitric oxide in 
      a population sample of children.
PG  - 678-82
LID - 10.1111/all.12378 [doi]
AB  - This study investigated the relationship between the specific immunoglobulin E 
      (IgE) profile for 40 allergens using a novel microarray technique (BioIC) and 
      fraction of exhaled nitric oxide (FeNO) in a population sample of 1321 children. 
      Significant positive associations were found between FeNO and sensitization to 
      mites (P < 0.001), animals (P = 0.001), cockroaches (P < 0.001), and foods 
      (P = 0.042), and furthermore, between FeNO and the number of sensitizations (all 
      P < 0.05) or the sum of specific IgE (all P </= 0.01) against the aforementioned 
      allergen categories. Specifically, sensitization to the following allergens was 
      significantly related to higher FeNO: Dermatophagoides pteronyssinus, 
      Dermatophagoides farina, Blomia tropicalis, cat, German cockroach, Oriental 
      cockroach, codfish, crab, shrimp, and cheese (all P </= 0.01). In conclusion, IgE 
      sensitization to mites, pets, cockroaches, seafood, and cheese, respectively, is 
      significantly associated with elevated FeNO levels in a dose-dependent fashion in 
      children. Our results provide new evidence that sensitization to certain food 
      allergens may contribute to prompt inflammation in the airways.
CI  - (c) 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Yao, T-C
AU  - Yao TC
AD  - Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang 
      Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, 
      Taiwan; Community Medicine Research Center, Chang Gung Memorial Hospital at 
      Keelung, Keelung, Taiwan.
FAU - Tsai, H-J
AU  - Tsai HJ
FAU - Tu, Y-L
AU  - Tu YL
FAU - Chang, S-W
AU  - Chang SW
FAU - Hua, M-C
AU  - Hua MC
FAU - Liao, S-L
AU  - Liao SL
FAU - Tsai, M-H
AU  - Tsai MH
FAU - Chiu, C-Y
AU  - Chiu CY
FAU - Lai, S-H
AU  - Lai SH
FAU - Yeh, K-W
AU  - Yeh KW
FAU - Huang, J-L
AU  - Huang JL
CN  - PATCH study group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140228
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Allergens)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Allergens/classification/immunology
MH  - Animals
MH  - Child
MH  - *Exhalation
MH  - Female
MH  - Humans
MH  - Hypersensitivity/epidemiology/immunology/metabolism
MH  - Immunoglobulin E/blood/*immunology
MH  - Male
MH  - Nitric Oxide/*metabolism
MH  - Prospective Studies
OTO - NOTNLM
OT  - Asian
OT  - allergic sensitization
OT  - atopy
OT  - children
OT  - exhaled nitric oxide
FIR - Huang, Jing-Long
IR  - Huang JL
FIR - Yao, Tsung-Chieh
IR  - Yao TC
FIR - Hua, Man-Chin
IR  - Hua MC
FIR - Tsai, Ming-Han
IR  - Tsai MH
FIR - Liao, Sui-Ling
IR  - Liao SL
FIR - Lai, Shen-Hao
IR  - Lai SH
FIR - Yeh, Kuo-Wei
IR  - Yeh KW
FIR - Tu, Yu-Ling
IR  - Tu YL
FIR - Chen, Li-Chen
IR  - Chen LC
FIR - Lee, Wen-I
IR  - Lee WI
FIR - Ou, Liang-Shiou
IR  - Ou LS
EDAT- 2014/03/01 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/03/01 06:00
PHST- 2014/01/18 00:00 [accepted]
PHST- 2014/03/01 06:00 [entrez]
PHST- 2014/03/01 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - 10.1111/all.12378 [doi]
PST - ppublish
SO  - Allergy. 2014 May;69(5):678-82. doi: 10.1111/all.12378. Epub 2014 Feb 28.