PMID- 24576503
OWN - NLM
STAT- MEDLINE
DCOM- 20150605
LR  - 20181202
IS  - 1751-732X (Electronic)
IS  - 1751-7311 (Linking)
VI  - 8
IP  - 5
DP  - 2014 May
TI  - Immunomodulatory factors and infectious agents associated with the hepatic gene 
      expression of the IGF system in nursery pigs.
PG  - 844-51
LID - 10.1017/S1751731114000275 [doi]
AB  - Recent findings suggest there is a complex interaction between the IGF system and 
      the inflammatory immune response. The objective of this study was to determine 
      whether gene expression of growth factors (IGF-1, IGF-binding protein-3 (IGFBP-3) 
      and growth hormone receptors (GHR)) in the liver is associated with gene 
      expression of immunomodulators in the liver, including C-reactive protein (CRP), 
      serum amyloid A (SAA), haptoglobin (Hp), interferon-alpha (IFN-alpha), IFN-gamma, tumour 
      necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-6, IL-10 and IL-18, as well as 
      with the presence of Salmonella spp., Lawsonia intracellularis, Brachyspira spp., 
      enterotoxigenic Escherichia coli, methicillin-resistant Staphylococcus aureus, 
      swine influenza virus, and porcine reproductive and respiratory syndrome virus 
      (PRRSV) in nursery pigs (n=74) from commercial farms (n=4). Gene expression was 
      quantified using reverse transcription quantitative-PCR (RT-qPCR) and the data 
      were modelled using logistic regression methods. Pigs with elevated IGF-1 
      expression were less likely to have increased expression of TNF-alpha (odds ratio 
      (OR)=0.14, P<0.01) and IL-18 (OR=0.19, P<0.05), and less likely to be colonized 
      with PRRSV (OR=0.03, P<0.01). Pigs with increased expression of IGFBP-3 were more 
      likely to have elevated IL-6 expression (OR=8.5, P<0.05). It was also observed 
      that IGFBP-3 and IGF-1 were significantly associated when Hp expression was low 
      (OR=30, P<0.05), but this association was not significant when Hp expression was 
      high (P=0.54). Pigs with increased expression of GHR were less likely to have 
      elevated expression of SAA (OR=0.01, P<0.05) and IL-1beta (OR=0.03, P<0.05), but 
      more likely to have increased expression of CRP (OR=290, P<0.01). Overall, there 
      appears to be an inverse association between the hepatic expression of the IGF 
      system (IGF-1, IGFBP-3, GHR) and certain cytokines (IL-1beta, IL-18, TNF-alpha) and 
      acute-phase proteins (SAA, Hp).
FAU - Slifierz, M J
AU  - Slifierz MJ
AD  - 1 Department of Population Medicine, Ontario Veterinary College, University of 
      Guelph, Guelph, ON, Canada, N1G 2W1.
FAU - Friendship, R
AU  - Friendship R
AD  - 1 Department of Population Medicine, Ontario Veterinary College, University of 
      Guelph, Guelph, ON, Canada, N1G 2W1.
FAU - de Lange, C F M
AU  - de Lange CF
AD  - 2 Department of Animal and Poultry Science, University of Guelph, Guelph, ON, 
      Canada, N1G 2W1.
FAU - Slavic, D
AU  - Slavic D
AD  - 3 Animal Health Laboratory, Ontario Veterinary College, University of Guelph, ON, 
      Canada, N1G 2W1.
FAU - Grgic, H
AU  - Grgic H
AD  - 1 Department of Population Medicine, Ontario Veterinary College, University of 
      Guelph, Guelph, ON, Canada, N1G 2W1.
FAU - Farzan, A
AU  - Farzan A
AD  - 1 Department of Population Medicine, Ontario Veterinary College, University of 
      Guelph, Guelph, ON, Canada, N1G 2W1.
LA  - eng
PT  - Journal Article
DEP - 20140227
PL  - England
TA  - Animal
JT  - Animal : an international journal of animal bioscience
JID - 101303270
RN  - 0 (Acute-Phase Proteins)
RN  - 0 (Cytokines)
RN  - 0 (Haptoglobins)
RN  - 0 (Immunologic Factors)
RN  - 0 (Receptors, Somatotropin)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Acute-Phase Proteins/genetics
MH  - Animals
MH  - Brachyspira/immunology
MH  - Cytokines/genetics
MH  - Female
MH  - *Gene Expression Regulation
MH  - Haptoglobins/metabolism
MH  - Immunologic Factors/*genetics
MH  - Insulin-Like Growth Factor I/*genetics
MH  - Lawsonia Bacteria/immunology
MH  - Liver/metabolism
MH  - Male
MH  - Methicillin-Resistant Staphylococcus aureus/immunology
MH  - Orthomyxoviridae/immunology
MH  - Porcine respiratory and reproductive syndrome virus/immunology
MH  - Random Allocation
MH  - Receptors, Somatotropin/*genetics
MH  - Salmonella/immunology
MH  - Swine/genetics/immunology/microbiology/*physiology
MH  - Swine Diseases/*immunology/microbiology
EDAT- 2014/03/01 06:00
MHDA- 2015/06/06 06:00
CRDT- 2014/03/01 06:00
PHST- 2014/03/01 06:00 [entrez]
PHST- 2014/03/01 06:00 [pubmed]
PHST- 2015/06/06 06:00 [medline]
AID - S1751731114000275 [pii]
AID - 10.1017/S1751731114000275 [doi]
PST - ppublish
SO  - Animal. 2014 May;8(5):844-51. doi: 10.1017/S1751731114000275. Epub 2014 Feb 27.