PMID- 24576679 OWN - NLM STAT- MEDLINE DCOM- 20141215 LR - 20181113 IS - 1873-507X (Electronic) IS - 0031-9384 (Linking) VI - 129 DP - 2014 Apr 22 TI - Peripheral interleukin-2 level is associated with negative symptoms and cognitive performance in schizophrenia. PG - 194-8 LID - S0031-9384(14)00101-2 [pii] LID - 10.1016/j.physbeh.2014.02.032 [doi] AB - Although several studies have pointed to a possible role of interleukin 2 (IL-2) in schizophrenia (SZ), association between IL-2 and the different groups of symptoms has not been explored. The objective of this study was to investigate a possible correlation of peripheral IL-2 levels with symptoms and cognitive performance in patients with SZ. In addition, we compared the plasma levels of IL-2 between patients with SZ and healthy controls. Twenty-nine chronically medicated outpatients with SZ according to DSM-IV were compared with twenty-six healthy controls. The patients were evaluated with the Positive and Negative Syndrome Scale (PANSS), the Calgary Depression Scale for Schizophrenia (CDSS), the Clinical Global Impression (CGI) and the Global Assessment of Functioning (GAF). All the participants had blood collected into EDTA tubes by venipuncture between 9:00 and 10:00AM. Plasma concentrations of IL-2 were determined by cytometric bead array. A computerized neuropsychological battery assessed verbal learning, verbal fluency, working memory, set shifting, executive function, inhibition and intelligence. Patients with SZ had lower levels of IL-2 than healthy controls (p<0.001). In the SZ group, IL-2 levels were positively correlated with scores in the digit span test (rho=0.416, P=0.025) and intelligence (rho=0.464, P=0.011). We also found a negative correlation between IL-2 and total score in the negative subscale of PANSS (rho=-0.447, p=0.015). Our findings suggest that IL-2 may be involved in the mechanisms related to cognitive deterioration and negative symptomatology in schizophrenia. CI - Copyright (c) 2014. Published by Elsevier Inc. FAU - Asevedo, Elson AU - Asevedo E AD - Schizophrenia Program (PROESQ), Department of Psychiatry, Federal University of Sao Paulo, Rua Machado Bittencourt, 222, Sao Paulo, SP, CEP 04044-000, Brazil; Interdisciplinary Laboratory of Clinical Neurosciences (LINC), Department of Psychiatry, Federal University of Sao Paulo, Rua Pedro de Toledo, 669, Edificio de Pesquisas II, third floor, Sao Paulo SP, CEP 04039-032, Brazil. Electronic address: elsonmed@gmail.com. FAU - Rizzo, Lucas B AU - Rizzo LB AD - Interdisciplinary Laboratory of Clinical Neurosciences (LINC), Department of Psychiatry, Federal University of Sao Paulo, Rua Pedro de Toledo, 669, Edificio de Pesquisas II, third floor, Sao Paulo SP, CEP 04039-032, Brazil. Electronic address: lucas-rizzo@hotmail.com. FAU - Gadelha, Ary AU - Gadelha A AD - Schizophrenia Program (PROESQ), Department of Psychiatry, Federal University of Sao Paulo, Rua Machado Bittencourt, 222, Sao Paulo, SP, CEP 04044-000, Brazil; Interdisciplinary Laboratory of Clinical Neurosciences (LINC), Department of Psychiatry, Federal University of Sao Paulo, Rua Pedro de Toledo, 669, Edificio de Pesquisas II, third floor, Sao Paulo SP, CEP 04039-032, Brazil. Electronic address: aryararipe@gmail.com. FAU - Mansur, Rodrigo B AU - Mansur RB AD - Interdisciplinary Laboratory of Clinical Neurosciences (LINC), Department of Psychiatry, Federal University of Sao Paulo, Rua Pedro de Toledo, 669, Edificio de Pesquisas II, third floor, Sao Paulo SP, CEP 04039-032, Brazil. Electronic address: rodrigomansur71@uol.com.br. FAU - Ota, Vanessa K AU - Ota VK AD - Interdisciplinary Laboratory of Clinical Neurosciences (LINC), Department of Psychiatry, Federal University of Sao Paulo, Rua Pedro de Toledo, 669, Edificio de Pesquisas II, third floor, Sao Paulo SP, CEP 04039-032, Brazil. Electronic address: vanessakota@gmail.com. FAU - Berberian, Arthur A AU - Berberian AA AD - Schizophrenia Program (PROESQ), Department of Psychiatry, Federal University of Sao Paulo, Rua Machado Bittencourt, 222, Sao Paulo, SP, CEP 04044-000, Brazil; Interdisciplinary Laboratory of Clinical Neurosciences (LINC), Department of Psychiatry, Federal University of Sao Paulo, Rua Pedro de Toledo, 669, Edificio de Pesquisas II, third floor, Sao Paulo SP, CEP 04039-032, Brazil. Electronic address: arthur.berberian@gmail.com. FAU - Scarpato, Bruno S AU - Scarpato BS AD - Interdisciplinary Laboratory of Clinical Neurosciences (LINC), Department of Psychiatry, Federal University of Sao Paulo, Rua Pedro de Toledo, 669, Edificio de Pesquisas II, third floor, Sao Paulo SP, CEP 04039-032, Brazil. Electronic address: brunosini@yahoo.com.br. FAU - Teixeira, Antonio L AU - Teixeira AL AD - Translational Psychoneuroimmunology Group, Federal University of Minas Gerais, Avenida Antonio Carlos, 6627, Pampulha, Belo Horizonte MG, CEP 31270-901, Brazil. Electronic address: altexr@gmail.com. FAU - Bressan, Rodrigo A AU - Bressan RA AD - Schizophrenia Program (PROESQ), Department of Psychiatry, Federal University of Sao Paulo, Rua Machado Bittencourt, 222, Sao Paulo, SP, CEP 04044-000, Brazil; Interdisciplinary Laboratory of Clinical Neurosciences (LINC), Department of Psychiatry, Federal University of Sao Paulo, Rua Pedro de Toledo, 669, Edificio de Pesquisas II, third floor, Sao Paulo SP, CEP 04039-032, Brazil. Electronic address: rodrigoabressan@gmail.com. FAU - Brietzke, Elisa AU - Brietzke E AD - Interdisciplinary Laboratory of Clinical Neurosciences (LINC), Department of Psychiatry, Federal University of Sao Paulo, Rua Pedro de Toledo, 669, Edificio de Pesquisas II, third floor, Sao Paulo SP, CEP 04039-032, Brazil. Electronic address: elisabrietzke@hotmail.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20140225 PL - United States TA - Physiol Behav JT - Physiology & behavior JID - 0151504 RN - 0 (IL2 protein, human) RN - 0 (Interleukin-2) SB - IM MH - Adult MH - Blood Chemical Analysis MH - *Cognition MH - Executive Function MH - Female MH - Humans MH - Intelligence Tests MH - Interleukin-2/*blood MH - Language MH - Learning MH - Male MH - *Memory, Short-Term MH - Neuropsychological Tests MH - Psychiatric Status Rating Scales MH - Schizophrenia/*blood MH - *Schizophrenic Psychology OTO - NOTNLM OT - Behavioral symptoms OT - Biological markers OT - Cognition OT - Interleukin-2 OT - Schizophrenia EDAT- 2014/03/01 06:00 MHDA- 2014/12/17 06:00 CRDT- 2014/03/01 06:00 PHST- 2013/08/03 00:00 [received] PHST- 2013/10/07 00:00 [revised] PHST- 2014/02/12 00:00 [accepted] PHST- 2014/03/01 06:00 [entrez] PHST- 2014/03/01 06:00 [pubmed] PHST- 2014/12/17 06:00 [medline] AID - S0031-9384(14)00101-2 [pii] AID - 10.1016/j.physbeh.2014.02.032 [doi] PST - ppublish SO - Physiol Behav. 2014 Apr 22;129:194-8. doi: 10.1016/j.physbeh.2014.02.032. Epub 2014 Feb 25.