PMID- 24576746
OWN - NLM
STAT- MEDLINE
DCOM- 20141124
LR  - 20161125
IS  - 1879-1379 (Electronic)
IS  - 0022-3956 (Linking)
VI  - 53
DP  - 2014 Jun
TI  - Increased plasma levels of BDNF and inflammatory markers in Alzheimer's disease.
PG  - 166-72
LID - S0022-3956(14)00028-4 [pii]
LID - 10.1016/j.jpsychires.2014.01.019 [doi]
AB  - Alzheimer's disease (AD) is the most common cause of dementia in the elderly. 
      Neurotrophic factors and inflammatory markers may play considerable roles in AD. 
      In this study we measured, through Enzyme-Linked Immunosorbent Assay, the plasma 
      levels of brain derived neurotrophic factor (BDNF), glial cell-derived 
      neurotrophic factor (GDNF) and neuronal growth factor (NGF), as well as tumor 
      necrosis factor-alpha soluble receptors, sTNFR1 and sTNFR2, and soluble 
      intercellular adhesion molecule 1 (sICAM-1), in 50 AD patients, 37 patients with 
      mild cognitive impairment (MCI) and 56 healthy elderly controls. BDNF levels, 
      expressed as median and interquartile range, were higher for AD patients (2545.3, 
      1497.4-4153.4 pg/ml) compared to controls (1503.8, 802.3-2378.4 pg/ml), 
      P < 0.001. sICAM-1 was also higher in AD patients. sTNFR1 levels were increased 
      in AD when compared to controls and also to MCI. GDNF, NGF and sTNFR2 levels 
      showed no significant differences among the studied groups. The increase in BDNF 
      might reflect a compensatory mechanism against early neurodegeneration and seems 
      to be related to inflammation. sTNFR1 appears to mark not only the inflammatory 
      state but also differentiates between MCI and AD, which may be an additional tool 
      for differentiating degrees of cognitive impairment.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Faria, Mayara Chaves
AU  - Faria MC
AD  - Departamento de Analises Clinicas e Toxicologicas, Faculdade de Farmacia, 
      Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; 
      Programa de Pos-Graduacao em Ciencias Farmaceuticas, Faculdade de Farmacia, 
      Universidade Federal de Minas Gerais, Av.Antonio Carlos, 6627, Pampulha, 
      31270-901 Belo Horizonte, Minas Gerais, Brazil.
FAU - Goncalves, Gisele Santos
AU  - Goncalves GS
AD  - Departamento de Analises Clinicas e Toxicologicas, Faculdade de Farmacia, 
      Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; 
      Programa de Pos-Graduacao em Ciencias Farmaceuticas, Faculdade de Farmacia, 
      Universidade Federal de Minas Gerais, Av.Antonio Carlos, 6627, Pampulha, 
      31270-901 Belo Horizonte, Minas Gerais, Brazil.
FAU - Rocha, Natalia Pessoa
AU  - Rocha NP
AD  - Laboratorio Interdisciplinar de Investigacao Medica, Faculdade de Medicina, 
      Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
FAU - Moraes, Edgar Nunes
AU  - Moraes EN
AD  - Ambulatorio de Idosos do Instituto Jenny de Andrade Faria do Hospital das 
      Clinicas da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, 
      Brazil; Departamento de Clinica Medica da Faculdade de Medicina da Universidade 
      Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
FAU - Bicalho, Maria Aparecida
AU  - Bicalho MA
AD  - Ambulatorio de Idosos do Instituto Jenny de Andrade Faria do Hospital das 
      Clinicas da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, 
      Brazil; Departamento de Clinica Medica da Faculdade de Medicina da Universidade 
      Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
FAU - Gualberto Cintra, Marco Tulio
AU  - Gualberto Cintra MT
AD  - Ambulatorio de Idosos do Instituto Jenny de Andrade Faria do Hospital das 
      Clinicas da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, 
      Brazil.
FAU - Jardim de Paula, Jonas
AU  - Jardim de Paula J
AD  - Ambulatorio de Idosos do Instituto Jenny de Andrade Faria do Hospital das 
      Clinicas da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, 
      Brazil.
FAU - Jose Ravic de Miranda, Luis Felipe
AU  - Jose Ravic de Miranda LF
AD  - Ambulatorio de Idosos do Instituto Jenny de Andrade Faria do Hospital das 
      Clinicas da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, 
      Brazil.
FAU - Clayton de Souza Ferreira, Alessandro
AU  - Clayton de Souza Ferreira A
AD  - Instituto Hermes Pardini, Belo Horizonte, Minas Gerais, Brazil.
FAU - Teixeira, Antonio Lucio
AU  - Teixeira AL
AD  - Laboratorio Interdisciplinar de Investigacao Medica, Faculdade de Medicina, 
      Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; 
      Departamento de Clinica Medica da Faculdade de Medicina da Universidade Federal 
      de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
FAU - Gomes, Karina Braga
AU  - Gomes KB
AD  - Departamento de Analises Clinicas e Toxicologicas, Faculdade de Farmacia, 
      Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
FAU - Carvalho, Maria das Gracas
AU  - Carvalho Md
AD  - Departamento de Analises Clinicas e Toxicologicas, Faculdade de Farmacia, 
      Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; 
      Programa de Pos-Graduacao em Ciencias Farmaceuticas, Faculdade de Farmacia, 
      Universidade Federal de Minas Gerais, Av.Antonio Carlos, 6627, Pampulha, 
      31270-901 Belo Horizonte, Minas Gerais, Brazil.
FAU - Sousa, Lirlandia P
AU  - Sousa LP
AD  - Departamento de Analises Clinicas e Toxicologicas, Faculdade de Farmacia, 
      Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; 
      Programa de Pos-Graduacao em Ciencias Farmaceuticas, Faculdade de Farmacia, 
      Universidade Federal de Minas Gerais, Av.Antonio Carlos, 6627, Pampulha, 
      31270-901 Belo Horizonte, Minas Gerais, Brazil. Electronic address: 
      lipsousa72@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140213
PL  - England
TA  - J Psychiatr Res
JT  - Journal of psychiatric research
JID - 0376331
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type I)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type II)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/*blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cognitive Dysfunction/blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Intercellular Adhesion Molecule-1/blood
MH  - Male
MH  - Nerve Growth Factor/blood
MH  - Receptors, Tumor Necrosis Factor, Type I/*blood
MH  - Receptors, Tumor Necrosis Factor, Type II/*blood
MH  - Statistics, Nonparametric
OTO - NOTNLM
OT  - Biomarkers
OT  - Brain derived neurotrophic factor
OT  - Inflammation
OT  - Neurodegeneration
OT  - Neurotrophic factors
OT  - Neurotrophins
OT  - sTNFR1
EDAT- 2014/03/01 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/03/01 06:00
PHST- 2013/10/07 00:00 [received]
PHST- 2013/12/19 00:00 [revised]
PHST- 2014/01/30 00:00 [accepted]
PHST- 2014/03/01 06:00 [entrez]
PHST- 2014/03/01 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - S0022-3956(14)00028-4 [pii]
AID - 10.1016/j.jpsychires.2014.01.019 [doi]
PST - ppublish
SO  - J Psychiatr Res. 2014 Jun;53:166-72. doi: 10.1016/j.jpsychires.2014.01.019. Epub 
      2014 Feb 13.