PMID- 24577369
OWN - NLM
STAT- MEDLINE
DCOM- 20141024
LR  - 20211021
IS  - 1538-943X (Electronic)
IS  - 1058-2916 (Print)
IS  - 1058-2916 (Linking)
VI  - 60
IP  - 2
DP  - 2014 Mar-Apr
TI  - Home discharge and out-of-hospital follow-up of total artificial heart patients 
      supported by a portable driver system.
PG  - 148-53
LID - 10.1097/MAT.0000000000000046 [doi]
AB  - To enhance ambulation and facilitate hospital discharge of total artificial heart 
      (TAH)-supported patients, we adapted a mobile ventricular assistance device (VAD) 
      driver (Excor) for TAH use and report on the performance of Excor-driven TAH 
      patients discharged home. Ten patients stabilized on a TAH, driven by the CSS 
      ("Circulatory Support System"), were progressively switched over to the Excor in 
      hospital over 14 days as a pilot, with daily hemodynamics and laboratory 
      parameters measured. Twenty-two stable TAH patients were subsequently placed on 
      the Excor, trained, and discharged home. Clinical and hemodynamic parameters were 
      followed. All pilot study patients were clinically stable on the Excor, with no 
      decrease in TAH output noted (6.3 + 0.3 L/min [day 1] vs. 5.8 + 0.2 L/min [day 
      14], p = 0.174), with a trend suggesting improvement of both hepatic and renal 
      function. Twenty-two TAH patients were subsequently successfully discharged home 
      on the portable driver and were supported out of hospital for up to 598 days 
      (range, 2-598; mean = 179 +/- 140 days), remaining ambulatory, New York Heart 
      Association (NYHA) class I or II, and free of readmission for 88.5% of the time 
      of support. TAH patients may be effectively and safely supported by a mobile 
      drive system. As such, the utility of the TAH may be extended to support patients 
      beyond the hospital, at home, with overall ambulatory freedom.
FAU - El Banayosy, Aly
AU  - El Banayosy A
AD  - From the *Penn State Milton S. Hershey Medical Center, Heart and Vascular 
      Institute, Hershey, PA; daggerHeart and Diabetes Center North Rhine-Westphalia, 
      Department of Thoracic and Cardiovascular Surgery, Bad Oeynhausen, Germany; 
      double daggerBerlin Heart, Berlin, Germany; and  section signSarver Heart Center, University of Arizona, 
      Tucson, AZ.
FAU - Kizner, Lukacz
AU  - Kizner L
FAU - Arusoglu, Latif
AU  - Arusoglu L
FAU - Morshuis, Michael
AU  - Morshuis M
FAU - Brehm, Christof
AU  - Brehm C
FAU - Koerfer, Reiner
AU  - Koerfer R
FAU - Schuermann, Christoph
AU  - Schuermann C
FAU - Smith, Richard G
AU  - Smith RG
FAU - Copeland, Jack G
AU  - Copeland JG
FAU - Slepian, Marvin J
AU  - Slepian MJ
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - United States
TA  - ASAIO J
JT  - ASAIO journal (American Society for Artificial Internal Organs : 1992)
JID - 9204109
SB  - IM
MH  - Female
MH  - Follow-Up Studies
MH  - *Heart, Artificial
MH  - *Hemodynamics
MH  - *Home Care Services
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Patient Discharge
MH  - Pilot Projects
PMC - PMC3942352
COIS- Disclosure: Dr. Copeland reports owning equity in SynCardia Systems. Mr. Smith 
      and Dr. Slepian report owning equity in SynCardia Systems and being paid for 
      part-time employment by the company. The other authors have no conflicts of 
      interest to report.
EDAT- 2014/03/01 06:00
MHDA- 2014/10/25 06:00
CRDT- 2014/03/01 06:00
PHST- 2014/03/01 06:00 [entrez]
PHST- 2014/03/01 06:00 [pubmed]
PHST- 2014/10/25 06:00 [medline]
AID - 00002480-201403000-00003 [pii]
AID - 10.1097/MAT.0000000000000046 [doi]
PST - ppublish
SO  - ASAIO J. 2014 Mar-Apr;60(2):148-53. doi: 10.1097/MAT.0000000000000046.