PMID- 24577922
OWN - NLM
STAT- MEDLINE
DCOM- 20140512
LR  - 20220316
IS  - 1011-601X (Print)
IS  - 1011-601X (Linking)
VI  - 27
IP  - 2
DP  - 2014 Mar
TI  - Bone Marrow Stromal Cell (BMSC) and skeletal aging: role of telomerase enzyme.
PG  - 321-33
AB  - Telomere shortening and telomerase deficiency have been linked with several age 
      related degenerative diseases. Moreover, degenerative changes in various 
      tissues/organs have been attributed to derangement of stem cell functions causing 
      regenerative tragedy. Bone marrow stromal cells (BMSCs) are considered the ideal 
      candidates for regenerative approaches owing to their beneficial effects in 
      numerous clinical applications. Thus, the effect of telomerase deficiency in 
      perpetrating age related changes in BMSC functions during in vitro culture; their 
      morphology, proliferation and differentiation, that can be extrapolated and 
      reasoned for skeletal aging is conversed in this review. Besides, information 
      regarding pertinent molecular and biochemical markers that can be employed to 
      examine the earliest events, during the course of BMSC aging, is also provided. 
      Additionally, impact of telomerase deficiency in enacting skeletal aging 
      phenotype and its associated microenvironment is also discussed. In the end, 
      further studies, using tissue specific models of telomerase deficiency, are 
      recommended as a future research strategy to advance our understanding of tissue 
      specific telomerase regulation.
FAU - Saeed, Hamid
AU  - Saeed H
AD  - Department of Endocrinology, School of Medicine, Stanford University, CA, United 
      States.
FAU - Iqtedar, Mehwish
AU  - Iqtedar M
AD  - Department of Bio-technology & Microbiology, Lahore College for Women University, 
      Lahore, Pakistan.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Pakistan
TA  - Pak J Pharm Sci
JT  - Pakistan journal of pharmaceutical sciences
JID - 9426356
RN  - EC 2.7.7.49 (Telomerase)
SB  - IM
MH  - Animals
MH  - Bone Development/physiology
MH  - Bone Marrow Cells/*enzymology/*physiology
MH  - Bone Marrow Transplantation
MH  - Cell Differentiation
MH  - Cell Proliferation
MH  - Cellular Senescence
MH  - Humans
MH  - Stromal Cells/*enzymology/*physiology
MH  - Telomerase/deficiency/*physiology
MH  - Telomere Shortening/physiology
EDAT- 2014/03/01 06:00
MHDA- 2014/05/13 06:00
CRDT- 2014/03/01 06:00
PHST- 2014/03/01 06:00 [entrez]
PHST- 2014/03/01 06:00 [pubmed]
PHST- 2014/05/13 06:00 [medline]
PST - ppublish
SO  - Pak J Pharm Sci. 2014 Mar;27(2):321-33.