PMID- 24578521
OWN - NLM
STAT- MEDLINE
DCOM- 20140909
LR  - 20151119
IS  - 1538-6724 (Electronic)
IS  - 0031-9023 (Linking)
VI  - 94
IP  - 7
DP  - 2014 Jul
TI  - Muscle atrophy, voluntary activation disturbances, and low serum concentrations 
      of IGF-1 and IGFBP-3 are associated with weakness in people with chronic stroke.
PG  - 957-67
LID - 10.2522/ptj.20130322 [doi]
AB  - BACKGROUND: The muscle weakness that is exhibited poststroke is due to a 
      multifactorial etiology involving the central nervous system and skeletal muscle 
      changes. Insulinlike growth factor 1 (IGF-1) and IGF binding protein 3 (IGFBP-3) 
      have been described as biomarkers of neuromuscular performance in many 
      conditions. However, no information about these biomarkers is available for 
      people with chronic hemiparesis. OBJECTIVE: The purpose of this study was to 
      investigate possible factors involved in muscle weakness, such as IGF-1 and 
      IGFBP-3 serum concentrations, muscle volume, and neuromuscular performance of the 
      knee flexors and extensors, in people with chronic hemiparesis poststroke. 
      DESIGN: This was a cross-sectional study. METHODS: A cross-sectional study was 
      performed on 14 individuals poststroke who were paired with healthy controls. 
      Mobility, function, balance, and quality of life were recorded as outcome 
      measures. Knee flexor and extensor muscle volumes and neuromuscular performance 
      were measured using nuclear magnetic resonance imaging, dynamometry, and 
      electromyography. The serum concentrations of IGF-1 and IGFBP-3 were quantified 
      by enzyme-linked immunosorbent assay (ELISA). RESULTS: The hemiparetic group had 
      low serum concentrations of IGF-1 (25%) and IGFBP-3 (40%); reduced muscle volume 
      in the vastus medialis (32%), vastus intermedius (29%), biceps femoris (16%), and 
      semitendinosus and semimembranosus (12%) muscles; reduced peak torque, power, and 
      work of the knee flexors and extensors; and altered agonist and antagonist muscle 
      activation compared with controls. CONCLUSIONS: Low serum concentrations of IGF-1 
      and IGFBP-3, deficits in neuromuscular performance, selective muscle atrophy, and 
      decreased agonist muscle activation were found in the group with chronic 
      hemiparesis poststroke. Both hemorrhagic and ischemic stroke were considered, and 
      the data reflect a chronic poststroke population with good function.
CI  - (c) 2014 American Physical Therapy Association.
FAU - Silva-Couto, Marcela de Abreu
AU  - Silva-Couto Mde A
AD  - M.A. Silva-Couto, MS, Department of Physical Therapy, Federal University of Sao 
      Carlos, Rodovia Washington Luis, Km 235, Monjolinho, Sao Carlos, Sao Paulo, 
      Brazil 13565-905. marcela.deabreu@yahoo.com.br russo@ufscar.br 
      thiagoluizrusso@gmail.com.
FAU - Prado-Medeiros, Christiane Lanatovitz
AU  - Prado-Medeiros CL
AD  - C.L. Prado-Medeiros, PhD, Department of Physical Therapy, Federal University of 
      Sao Carlos.
FAU - Oliveira, Ana Beatriz
AU  - Oliveira AB
AD  - A.B. Oliveira, PhD, Department of Physical Therapy, Federal University of Sao 
      Carlos.
FAU - Alcantara, Carolina Carmona
AU  - Alcantara CC
AD  - C.C. Alcantara, MS, Department of Physical Therapy, Federal University of Sao 
      Carlos.
FAU - Guimaraes, Araci Teixeira
AU  - Guimaraes AT
AD  - A.T. Guimaraes, Department of Physical Therapy, Federal University of Sao Carlos.
FAU - Salvini, Tania de Fatima
AU  - Salvini Tde F
AD  - T.F. Salvini, PhD, Department of Physical Therapy, Federal University of Sao 
      Carlos.
FAU - Mattioli, Rosana
AU  - Mattioli R
AD  - R. Mattioli, PhD, Department of Physical Therapy, Federal University of Sao 
      Carlos.
FAU - de Russo, Thiago Luiz
AU  - de Russo TL
AD  - T.L. Russo, PhD, Laboratorio de Pesquisa em Fisioterapia Neurologica (LaFiN) and 
      Department of Physical Therapy, Federal University of Sao Paulo, Rodovia 
      Washington Luis, Km 235, Monjolinho, Sao Carlos, Sao Paulo, Brazil 13565-905. 
      marcela.deabreu@yahoo.com.br russo@ufscar.br thiagoluizrusso@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140227
PL  - United States
TA  - Phys Ther
JT  - Physical therapy
JID - 0022623
RN  - 0 (Biomarkers)
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Electromyography
MH  - Female
MH  - Humans
MH  - Insulin-Like Growth Factor Binding Protein 3/*blood
MH  - Insulin-Like Growth Factor I/*metabolism
MH  - Knee/physiopathology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Muscle Strength/physiology
MH  - Muscle Strength Dynamometer
MH  - Muscular Atrophy/*blood/etiology/physiopathology
MH  - Paresis/*blood/complications/physiopathology
MH  - Postural Balance
MH  - Quadriceps Muscle/pathology/*physiopathology
MH  - Quality of Life
MH  - Stroke/blood/complications/*physiopathology
MH  - Torque
MH  - Walking
EDAT- 2014/03/01 06:00
MHDA- 2014/09/10 06:00
CRDT- 2014/03/01 06:00
PHST- 2014/03/01 06:00 [entrez]
PHST- 2014/03/01 06:00 [pubmed]
PHST- 2014/09/10 06:00 [medline]
AID - ptj.20130322 [pii]
AID - 10.2522/ptj.20130322 [doi]
PST - ppublish
SO  - Phys Ther. 2014 Jul;94(7):957-67. doi: 10.2522/ptj.20130322. Epub 2014 Feb 27.