PMID- 24579063
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 2220-8372 (Print)
IS  - 2220-8372 (Electronic)
IS  - 2220-8372 (Linking)
VI  - 2
IP  - 4
DP  - 2012 Dec 21
TI  - Effect of universal MODS access on pulmonary tuberculosis treatment outcomes in 
      new patients in Peru.
PG  - 162-167
AB  - SETTING: Primary health care centres in Callao, Peru. OBJECTIVES: To evaluate the 
      effect of universal access to the microscopic-observation drug susceptibility 
      (MODS) assay on treatment outcomes in new and primary multidrug-resistant 
      tuberculosis (MDR-TB) patients and on the process of drug susceptibility testing 
      (DST). DESIGN: Retrospective review of tuberculosis (TB) registers and clinical 
      records before (2007) and after (2009) the introduction of MODS in 2008. RESULTS: 
      There were 281 patients in each cohort. Favourable treatment outcomes for 2007 
      (81%) and 2009 (77%) cohorts were similar. There was an increase in loss to 
      follow-up (from 6% to 10%, P = 0.04) and a reduction in failure rates (from 4% to 
      0.4%, P = 0.01) in the 2009 compared with the 2007 cohort. In new MDR-TB cases (n 
      = 22), a favourable treatment outcome was improved (from 46% to 82%, P = 0.183) 
      in the 2009 cohort. DST coverage improved (from 24% to 74%, P < 0.001), and a 
      significant reduction in time to diagnosis of drug-susceptible (from 118 to 33 
      days, P < 0.001) and MDR-TB (from 158 to 52 days, P =30.003) was observed in the 
      2009 cohort. CONCLUSION: Universal access to MODS increased DST coverage, reduced 
      the time required to obtain DST results and was associated with reduced failure 
      rates. MODS can make an important contribution to TB management and control in 
      Peru.
FAU - Mendoza-Ticona, A
AU  - Mendoza-Ticona A
AD  - USAID/Peru Quality Healthcare Project, Lima, Peru.
FAU - Alarcon, E
AU  - Alarcon E
AD  - International Union Against Tuberculosis and Lung Disease, Paris, France.
FAU - Alarcon, V
AU  - Alarcon V
AD  - Estrategia Sanitaria Nacional de Prevencion y Control de la Tuberculosis, 
      Ministerio de Salud, Lima, Peru.
FAU - Bissell, K
AU  - Bissell K
AD  - International Union Against Tuberculosis and Lung Disease, Paris, France ; The 
      University of Auckland, Auckland, New Zealand.
FAU - Castillo, E
AU  - Castillo E
AD  - Direccion Regional de Salud de Callao, Callao, Peru.
FAU - Sabogal, I
AU  - Sabogal I
AD  - Instituto de Medicina Tropical 'Daniel A. Carrion', Universidad Nacional Mayor de 
      San Marcos, Lima, Peru.
FAU - Mora, J
AU  - Mora J
AD  - Direccion Regional de Salud de Callao, Callao, Peru.
FAU - Moore, D
AU  - Moore D
AD  - London School of Hygiene & Tropical Medicine, London, UK.
FAU - Harries, A D
AU  - Harries AD
AD  - International Union Against Tuberculosis and Lung Disease, Paris, France ; London 
      School of Hygiene & Tropical Medicine, London, UK.
LA  - eng
GR  - U2R TW007368/TW/FIC NIH HHS/United States
PT  - Journal Article
PL  - France
TA  - Public Health Action
JT  - Public health action
JID - 101624961
PMC - PMC3933568
MID - NIHMS550232
OTO - NOTNLM
OT  - MDR-TB
OT  - MODS
OT  - Peru
OT  - drug-resistant TB
OT  - operational research
OT  - rapid test
EDAT- 2012/12/21 00:00
MHDA- 2012/12/21 00:01
PMCR- 2012/12/21
CRDT- 2014/03/01 06:00
PHST- 2014/03/01 06:00 [entrez]
PHST- 2012/12/21 00:00 [pubmed]
PHST- 2012/12/21 00:01 [medline]
PHST- 2012/12/21 00:00 [pmc-release]
AID - 10.5588/pha.12.0033 [doi]
PST - ppublish
SO  - Public Health Action. 2012 Dec 21;2(4):162-167. doi: 10.5588/pha.12.0033.