PMID- 24579364
OWN - NLM
STAT- MEDLINE
DCOM- 20140401
LR  - 20240222
IS  - 1000-0607 (Print)
IS  - 1000-0607 (Linking)
VI  - 38
IP  - 6
DP  - 2013 Dec
TI  - [Effect of acupoint heat-sensitive moxibustion intervention on serum osteopontin 
      and matrix metalloproteinase-3 in patients with acute knee pain].
PG  - 488-92
AB  - OBJECTIVE: To observe the clinical effect of acupoint heat-sensitive moxibustion 
      for acut knee arthralgia and to analyze its effect on serum osteopontin (OPN) and 
      matrix metalloproteinase-3 (MMP-3) contents in patients with knee osteoarthritis 
      so as to study its mechanism underlying improving arthralgia. METHODS: One 
      hundred and forty-four patients with acute knee knee osteoarthritis were randomly 
      allocated to acupoint heat-sensitive moxibustion (moxibustion), 
      electroacupuncture (EA) and medication groups. Patients of the moxibustion group 
      were treated by suspended moxibustion over bilateral Weizhong (BL 40) for 40 min 
      each point, once daily for 15 days. Patients of the EA group were treated by EA 
      stimulation of Neixiyan (EX-LE 4), Dubi (ST 35), Xuehai (SP 10) and Liangqiu (ST 
      34) for 30 min, once daily for 15 days; and those of the medication group treated 
      by oral administration of Sanqi Tongshu capsules (Panax Notoginseng, etc. used 
      for promoting blood circulation and removing blood stasis), 3 times daily for 15 
      days. Serum OPN and MMP-3 levels were detected with ELISA. RESULTS: Following the 
      treatment, of the 50, 50 and 44 cases in the moxibustion, EA and medication 
      groups, 24, 20 and 14 were excellent, 18, 16 and 13 were good in therapeutic 
      effect, 7, 4, and 3 were effective, and 1, 10, and 14 invalid, with the excellent 
      and good rates being 84%, 72.0% and 61.4%, respectively. Serum OPN content of the 
      moxibistion and EA groups, and serum MMP-3 content of the moxibustion group were 
      reduced considerably in comparison with pre-treatment in the same one group (P < 
      0.01), while serum OPN level of the medication group and MMP-3 of the EA group 
      were decreased slightly. The effect of moxibustion was evidently superior to that 
      of medication in lowering serum OPN level (P < 0.05) and superior to that of both 
      EA and medication in lowering serum MMP-3 content (P < 0.05). CONCLUSION: 
      Acupoint heat-sensitive moxibustion has a good therapeutic effect in relieving 
      acute knee arthralgia, which may be related to its effects in decreasing serum 
      OPN and MMP-3 levels.
FAU - Cai, Guo-wei
AU  - Cai GW
AD  - Department of Acu-moxi-bustion, The Affiliated Union Hospital of Tongji Medical 
      College of Huazhong University of Science and Technology, Wuhan 430022, China. 
      cgw645@163.com
FAU - Li, Jing
AU  - Li J
AD  - Department of Acu-moxi-bustion, The Affiliated Union Hospital of Tongji Medical 
      College of Huazhong University of Science and Technology, Wuhan 430022, China.
FAU - Xu, Xiao-juan
AU  - Xu XJ
AD  - Rehabilitation Department of Chinese Medicine, the Affiliation Hospital of Tongji 
      Medical College of Huazhong University of Science and Technology, Wuhan, 430056.
FAU - Xue, Yuan-zhi
AU  - Xue YZ
AD  - Department of Acu-moxi-bustion, The Affiliated Union Hospital of Tongji Medical 
      College of Huazhong University of Science and Technology, Wuhan 430022, China.
FAU - Li, Gang
AU  - Li G
AD  - Department of Acu-moxi-bustion, The Affiliated Union Hospital of Tongji Medical 
      College of Huazhong University of Science and Technology, Wuhan 430022, China.
FAU - Wu, Man
AU  - Wu M
AD  - Department of Acu-moxi-bustion, The Affiliated Union Hospital of Tongji Medical 
      College of Huazhong University of Science and Technology, Wuhan 430022, China.
FAU - Li, Peng-fei
AU  - Li PF
AD  - Department of Acu-moxi-bustion, The Affiliated Union Hospital of Tongji Medical 
      College of Huazhong University of Science and Technology, Wuhan 430022, China.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhen Ci Yan Jiu
JT  - Zhen ci yan jiu = Acupuncture research
JID - 8507710
RN  - 106441-73-0 (Osteopontin)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - *Acupuncture Points
MH  - Adult
MH  - Aged
MH  - Female
MH  - Hot Temperature
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 3/*blood
MH  - Middle Aged
MH  - *Moxibustion
MH  - Osteoarthritis, Knee/blood/*therapy
MH  - Osteopontin/*blood
EDAT- 2014/03/04 06:00
MHDA- 2014/04/02 06:00
CRDT- 2014/03/04 06:00
PHST- 2014/03/04 06:00 [entrez]
PHST- 2014/03/04 06:00 [pubmed]
PHST- 2014/04/02 06:00 [medline]
PST - ppublish
SO  - Zhen Ci Yan Jiu. 2013 Dec;38(6):488-92.