PMID- 24579411
OWN - NLM
STAT- MEDLINE
DCOM- 20140404
LR  - 20140303
IS  - 0332-3102 (Print)
IS  - 0332-3102 (Linking)
VI  - 106
IP  - 10
DP  - 2013 Nov-Dec
TI  - The intensity of QuantiFERON TB-gold response does not differentiate active from 
      latent tuberculosis.
PG  - 308-10
AB  - We analyzed positive QuantiFERON (QFT) assays, performed between July 2009 and 
      April 2011 in the Mercy University Hospital, Cork, Ireland, which included, 94 
      patients with latent tuberculosis (LTBI) and 35 patients with active 
      tuberculosis. There was no difference in the intensity of response between 
      patients with LTBI and active tuberculosis (p = 0.1589). In patients with LTBI, 
      there were no correlations between age (p = 0.353), sex (p = 0.476), smoking (p = 
      0.323), contact (p = 0.612), Mantoux response (p = 0.055), Irish nationality 
      (p=0.768), previous BCG vaccination (p = 0.504), WCC (p = 0.187), lymphocyte 
      count (p = 0.786), neutrophil count (p = 0.157) and the intensity of QFT 
      response. Similarly in patients with active TB, there were no correlations 
      between these variables and QFT response. The intensity of QFT response does not 
      help to differentiate active from LTBI. The intensity of QFT response is not 
      influenced by age, sex, smoking, remoteness of contact history, Mantoux response, 
      nationality, CXR abnormalities, BCG vaccination and peripheral lymphocyte count.
FAU - Khan, F
AU  - Khan F
AD  - Department of Respiratory Medicine, Mercy University Hospital, Grenville Place, 
      Cork. drfaheemkhan@gmail.com
FAU - Cotter, O
AU  - Cotter O
AD  - Department of Respiratory Medicine, Mercy University Hospital, Grenville Place, 
      Cork.
FAU - Kennedy, B
AU  - Kennedy B
AD  - Department of Respiratory Medicine, Mercy University Hospital, Grenville Place, 
      Cork.
FAU - Clair, J
AU  - Clair J
AD  - Department of Respiratory Medicine, Mercy University Hospital, Grenville Place, 
      Cork.
FAU - O'Connor, B
AU  - O'Connor B
AD  - Department of Respiratory Medicine, Mercy University Hospital, Grenville Place, 
      Cork.
FAU - Collins, J
AU  - Collins J
AD  - Department of Respiratory Medicine, Mercy University Hospital, Grenville Place, 
      Cork.
FAU - Curran, D
AU  - Curran D
AD  - Department of Respiratory Medicine, Mercy University Hospital, Grenville Place, 
      Cork.
FAU - O'Connor, T
AU  - O'Connor T
AD  - Department of Respiratory Medicine, Mercy University Hospital, Grenville Place, 
      Cork.
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Ir Med J
JT  - Irish medical journal
JID - 0430275
SB  - IM
MH  - Adult
MH  - Bacteriological Techniques/methods
MH  - Female
MH  - Humans
MH  - Immunoassay/*methods
MH  - Latent Tuberculosis/*diagnosis/immunology
MH  - Male
MH  - Middle Aged
EDAT- 2014/03/04 06:00
MHDA- 2014/04/05 06:00
CRDT- 2014/03/04 06:00
PHST- 2014/03/04 06:00 [entrez]
PHST- 2014/03/04 06:00 [pubmed]
PHST- 2014/04/05 06:00 [medline]
PST - ppublish
SO  - Ir Med J. 2013 Nov-Dec;106(10):308-10.