PMID- 24579476
OWN - NLM
STAT- MEDLINE
DCOM- 20140401
LR  - 20140303
IS  - 1003-9279 (Print)
IS  - 1003-9279 (Linking)
VI  - 27
IP  - 4
DP  - 2013 Aug
TI  - [Relationship between effect of lamivudine in the treatment of cirrhotic patients 
      with uncompensated hepatitis B with HBV genotypes and cytotoxic T lymphocyte].
PG  - 283-5
AB  - OBJECTIVE: To explore relationship between effect of Lamivudine in the treatment 
      of cirrhotic patients with uncompensated hepatitis B with hepatitis B virus 
      (HBV)genotypes and HBV specific cytotoxic T lymphocytes (CTL). METHODS: 80 cases 
      of uncompensated cirrhotic hepatitis B (40 cases with genotype B and 40 with 
      genotype C), HBV DNA positive, HBeAg positive and human leukocyte antigen 
      (HLA)-A2 positive,were treated with Lamivudine 100 mg/d, one year later, its 
      effect and relationship with HBV genotypes and HBV specific CTL were observed. 
      RESULTS: HBV DNA turned negative:40 cases with genotype B turned negative (100%). 
      In the 9th and 10th month of treatment, there was one case with genotype C had 
      YMDD variation respectively and Adefovir dipivoxil was used for treatment, of the 
      rest 38 cases, HBV DNA of 26 cases (68.42%) turned negative,HBV DNA negative rate 
      of patients with genotype is lower than that of patients with genotype B, chi2 = 
      14.91, P < 0.01. HBeAg turned negative: 18 cases with genotype B (45%) turned 
      negative, more than that of patients with genotype C (7 cases, 18.42%), chi2 = 
      6.32, P < 0.05. Peripheral blood HBV specific CTL level: before treatment, it was 
      (0.33 +/- 0.03)% of patients with genotype B,higher than that of patients with 
      genotype C [(0.11 +/- 0.02)%], t = 8.12, P < 0.001. 1 year after treatment: it 
      was (0.44 +/- 0.04)% of patients with genotype B, higher than that before 
      treatment, t = 4.01, P < 0.001, it was also higher than that of patients with 
      genotype C 1 year after treatment [(0.23 +/- 0.03)%], t = 5.63, P < 0.01, alanine 
      amino-transferase (ALT) returned to normal: 38 cases with genotype B (95%) 
      returned to normal, more than that of patients with genotype C (28 cases, 
      73.68%), X2 = 6.79, P < 0.01. CONCLUSION: Effect of Lamivudinein the treatment of 
      cirrhotic patients with uncompensated hepatitis B is better in patients with 
      genotype B than patients with genotype C, its mechanism may be related to lower 
      level of HBV specific CTL in patients with genotype C than patients with genotype 
      B.
FAU - Wang, Dong
AU  - Wang D
AD  - Wuxi Hospital for Infectious Diseases, Wuxi 214005, China.
FAU - Gu, Xi-Bing
AU  - Gu XB
AD  - Wuxi Hospital for Infectious Diseases, Wuxi 214005, China.
FAU - Zhu, Yin-Fang
AU  - Zhu YF
AD  - Wuxi Hospital for Infectious Diseases, Wuxi 214005, China.
FAU - Xiao-Juan, Yang
AU  - Xiao-Juan Y
AD  - Wuxi Hospital for Infectious Diseases, Wuxi 214005, China.
FAU - Jiang, Xiang-Hu
AU  - Jiang XH
AD  - Wuxi Hospital for Infectious Diseases, Wuxi 214005, China.
FAU - Huang, Li-Hua
AU  - Huang LH
AD  - Wuxi Hospital for Infectious Diseases, Wuxi 214005, China.
FAU - Qiu, Yuan-Wang
AU  - Qiu YW
AD  - Wuxi Hospital for Infectious Diseases, Wuxi 214005, China.
FAU - Wu, Hang-Yuan
AU  - Wu HY
AD  - Wuxi Hospital for Infectious Diseases, Wuxi 214005, China.
FAU - Yu, Ping
AU  - Yu P
AD  - Wuxi Hospital for Infectious Diseases, Wuxi 214005, China.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi
JT  - Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang 
      bingduxue zazhi = Chinese journal of experimental and clinical virology
JID - 9602873
RN  - 0 (Antiviral Agents)
RN  - 2T8Q726O95 (Lamivudine)
RN  - EC 2.6.1.2 (Alanine Transaminase)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alanine Transaminase/metabolism
MH  - Antiviral Agents/*therapeutic use
MH  - Female
MH  - Genotype
MH  - Hepatitis B/*drug therapy/enzymology/*immunology/virology
MH  - Hepatitis B virus/drug effects/*genetics/isolation & purification
MH  - Humans
MH  - Lamivudine/*therapeutic use
MH  - Liver Cirrhosis/*drug therapy/enzymology/*immunology/virology
MH  - Male
MH  - Middle Aged
MH  - T-Lymphocytes, Cytotoxic/*immunology
EDAT- 2014/03/04 06:00
MHDA- 2014/04/02 06:00
CRDT- 2014/03/04 06:00
PHST- 2014/03/04 06:00 [entrez]
PHST- 2014/03/04 06:00 [pubmed]
PHST- 2014/04/02 06:00 [medline]
PST - ppublish
SO  - Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2013 Aug;27(4):283-5.