PMID- 24579822
OWN - NLM
STAT- MEDLINE
DCOM- 20141218
LR  - 20140507
IS  - 1399-0012 (Electronic)
IS  - 0902-0063 (Linking)
VI  - 28
IP  - 5
DP  - 2014 May
TI  - Human herpesvirus-6 encephalopathy after hematopoietic stem cell transplantation 
      and class I human leukocyte antigen.
PG  - 540-5
LID - 10.1111/ctr.12342 [doi]
AB  - Human herpesvirus-6 (HHV-6) encephalopathy is a serious complication of 
      allogeneic hematopoietic stem cell transplantation (allo-HSCT). Although 
      reactivation of HHV-6 is often observed after allo-HSCT, encephalopathy only 
      affects a few patients with HHV-6 reactivation. Human leukocyte antigen (HLA) 
      class I is expressed by most somatic cells, and a relationship between some class 
      I alleles and neurological diseases has been reported. The HHV-6 load at two, 
      three, and four weeks after allo-HSCT was examined. HHV-6 encephalopathy was 
      diagnosed from symptoms, results of cerebrospinal fluid examination, and magnetic 
      resonance imaging findings. The relation between HHV-6 reactivation or 
      encephalopathy and the HLA class I status of the recipients was investigated. In 
      130 patients, 147 allo-HSCT transplantation procedures were carried out. HHV-6 
      reactivation and encephalopathy occurred in 56 and nine procedures, respectively. 
      HLA mismatch (p = 0.008) and unrelated donor (p = 0.001) were associated with 
      HHV-6 reactivation, but not with HHV-6 encephalopathy. HHV-6 encephalopathy was 
      more frequent in patients with HLA-B*40:06 (p = 0.027). In addition, HLA-A*26:01 
      and HLA-B*40:06 were found to be associated with each other (p = 0.089), while 
      HLA-B*40:06 and HLA-C*08:01 showed a significant association (p < 0.001). The HLA 
      class I alleles of recipients may be associated with the occurrence of HHV-6 
      encephalopathy after allo-HSCT.
CI  - (c) 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Yamamoto, Wataru
AU  - Yamamoto W
AD  - Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan.
FAU - Ogusa, Eriko
AU  - Ogusa E
FAU - Matsumoto, Kenji
AU  - Matsumoto K
FAU - Maruta, Atsuo
AU  - Maruta A
FAU - Ishigatsubo, Yoshiaki
AU  - Ishigatsubo Y
FAU - Kanamori, Heiwa
AU  - Kanamori H
LA  - eng
PT  - Journal Article
DEP - 20140402
PL  - Denmark
TA  - Clin Transplant
JT  - Clinical transplantation
JID - 8710240
RN  - 0 (DNA, Viral)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - DNA, Viral/genetics
MH  - Encephalitis, Viral/*etiology/metabolism
MH  - Female
MH  - Follow-Up Studies
MH  - Hematologic Neoplasms/immunology/metabolism/*therapy
MH  - Hematopoietic Stem Cell Transplantation/*adverse effects
MH  - Herpesvirus 6, Human/*pathogenicity
MH  - Histocompatibility Antigens Class I/*metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Roseolovirus Infections/*etiology/metabolism
MH  - Transplantation, Homologous
MH  - Virus Activation
OTO - NOTNLM
OT  - encephalopathy
OT  - human herpesvirus-6
OT  - human leukocyte antigen
OT  - reactivation
OT  - stem cell transplantation
EDAT- 2014/03/04 06:00
MHDA- 2014/12/19 06:00
CRDT- 2014/03/04 06:00
PHST- 2014/02/21 00:00 [accepted]
PHST- 2014/03/04 06:00 [entrez]
PHST- 2014/03/04 06:00 [pubmed]
PHST- 2014/12/19 06:00 [medline]
AID - 10.1111/ctr.12342 [doi]
PST - ppublish
SO  - Clin Transplant. 2014 May;28(5):540-5. doi: 10.1111/ctr.12342. Epub 2014 Apr 2.