PMID- 24579966
OWN - NLM
STAT- MEDLINE
DCOM- 20141027
LR  - 20221207
IS  - 1840-4812 (Electronic)
IS  - 1512-8601 (Print)
IS  - 1512-8601 (Linking)
VI  - 14
IP  - 1
DP  - 2014 Feb
TI  - An assessment of correlation between serum asymmetric dimethylarginine and 
      glycated haemoglobin in patients with type 2 diabetes mellitus.
PG  - 21-4
AB  - Studies that investigated an association between asymmetric dimethylarginine 
      (ADMA) and glycated haemoglobin (HbA1c) in type 2 diabetes mellitus (T2DM) have 
      given discordant results. The aim of this study was to determine and compare 
      serum ADMA concentration in patients with T2DM and healthy controls, and to 
      assess correlation between ADMA and HbA1c in patients with T2DM. Serum ADMA 
      concentration was determined by ELISA method with the use of ADMA (R) - ELISA kit 
      (DLD Diagnostics, Hamburg, Germany) and HbA1c levels were determined by an 
      immunoturbidimetric method in 60 patients with T2DM and 60 healthy individuals 
      matched for age and sex. Results have shown that mean serum ADMA concentration 
      was significantly higher in T2DM patients (1.54+/-0.06 mumol/L) compared to mean 
      serum ADMA concentration (0.62+/-0.02 mumol/L; p<0.0001) in healthy subjects. A 
      significant, positive, correlation between serum ADMA concentration and HbA1c 
      levels was observed (r=0.494; p<0.01) in T2DM patients. Our results suggest that 
      there is an association between endothelial dysfunction and glycaemic control in 
      type 2 diabetes mellitus. Possible explanation for obtained results may be 
      oxidative stress that is increased in conditions of hyperglycaemia and it also 
      promotes endothelial dysfunction. Larger, longitudinal studies are required that 
      will evaluate relation between metabolic abnormalities and increased ADMA levels 
      in patients with type 2 diabetes mellitus.
FAU - Zaciragic, Asja
AU  - Zaciragic A
AD  - Department of Physiology, Faculty of Medicine, University of Sarajevo, Cekalusa 
      90, 71000 Sarajevo, Bosnia and Herzegovina.
FAU - Huskic, Jasminko
AU  - Huskic J
AD  - Department of Physiology, Faculty of Medicine, University of Sarajevo, Cekalusa 
      90, 71000 Sarajevo, Bosnia and Herzegovina.
FAU - Mulabegovic, Nedzad
AU  - Mulabegovic N
AD  - Institute of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of 
      Medicine, University of Sarajevo, Cekalusa 90, 71000 Sarajevo, Bosnia and 
      Herzegovina.
FAU - Avdagic, Nesina
AU  - Avdagic N
AD  - Department of Physiology, Faculty of Medicine, University of Sarajevo, Cekalusa 
      90, 71000 Sarajevo, Bosnia and Herzegovina.
FAU - Valjevac, Amina
AU  - Valjevac A
AD  - Department of Physiology, Faculty of Medicine, University of Sarajevo, Cekalusa 
      90, 71000 Sarajevo, Bosnia and Herzegovina.
FAU - Hasic, Sabaheta
AU  - Hasic S
AD  - Department of Biochemistry, Faculty of Medicine, University of Sarajevo, Cekalusa 
      90, 71000 Sarajevo, Bosnia and Herzegovina.
FAU - Jadric, Radivoj
AU  - Jadric R
LA  - eng
PT  - Journal Article
PL  - Bosnia and Herzegovina
TA  - Bosn J Basic Med Sci
JT  - Bosnian journal of basic medical sciences
JID - 101200947
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 63CV1GEK3Y (N,N-dimethylarginine)
RN  - 94ZLA3W45F (Arginine)
SB  - IM
MH  - Arginine/*analogs & derivatives/blood
MH  - Blood Glucose/analysis
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Glycated Hemoglobin/*analysis
MH  - Humans
MH  - Hyperglycemia/drug therapy
MH  - Male
MH  - Middle Aged
MH  - Nephelometry and Turbidimetry
MH  - Oxidative Stress
PMC - PMC4333946
EDAT- 2014/03/04 06:00
MHDA- 2014/10/28 06:00
PMCR- 2014/02/01
CRDT- 2014/03/04 06:00
PHST- 2014/03/04 06:00 [entrez]
PHST- 2014/03/04 06:00 [pubmed]
PHST- 2014/10/28 06:00 [medline]
PHST- 2014/02/01 00:00 [pmc-release]
AID - BJBMS-14-21 [pii]
AID - 10.17305/bjbms.2014.2291 [doi]
PST - ppublish
SO  - Bosn J Basic Med Sci. 2014 Feb;14(1):21-4. doi: 10.17305/bjbms.2014.2291.