PMID- 24580371
OWN - NLM
STAT- MEDLINE
DCOM- 20140908
LR  - 20211025
IS  - 1532-4303 (Electronic)
IS  - 0277-0903 (Linking)
VI  - 51
IP  - 6
DP  - 2014 Aug
TI  - OX40 ligand: a potential costimulatory molecule in atopic asthma.
PG  - 573-7
LID - 10.3109/02770903.2014.897729 [doi]
AB  - OBJECTIVE: We aimed to assess the percentage of peripheral blood B-lymphocytes 
      expressing OX40 ligand (OX40L) in adult atopic and non-atopic asthmatic patients, 
      and in healthy controls. METHODS: This case-control study included 15 atopic 
      asthmatic patients, 15 non-atopic asthmatic patients, and 15 healthy controls. 
      Atopic status was determined by skin prick test reaction to the most common 
      locally-encountered allergens. For all subjects, pulmonary function tests and 
      measurement of total serum immunoglobulin E (IgE) levels by ELISA were performed. 
      In addition, the percentage of B-lymphocytes expressing OX40L was assessed by 
      flow cytometry in all three groups. RESULTS: OX40L expression was significantly 
      higher in atopic asthmatics than in non-atopic asthmatics and controls, but did 
      not differ significantly between non-atopic asthmatics or controls. Among atopic 
      asthmatics, OX40L expression correlated positively with total serum IgE levels, 
      but not with age, disease duration, or values of forced expiratory volume in the 
      first second. CONCLUSION: The over-expression of OX40L in atopic asthmatic 
      patients appears to be linked to markers of the atopic status as total serum IgE, 
      and signifies the vital role of OX40L in the atopic mechanism. Further 
      large-scale studies are needed to investigate the role of OX40L in other atopic 
      diseases and its relation to disease activity and severity.
FAU - Farres, Mohamed Nazmy
AU  - Farres MN
AD  - Department of Allergy and Clinical Immunology and.
FAU - Sabry, Mohamed Kamel
AU  - Sabry MK
FAU - Ahmed, Eman Elsayed
AU  - Ahmed EE
FAU - Elkady, Hossam Moustafa
AU  - Elkady HM
FAU - Mohamed, Nesrine Aly
AU  - Mohamed NA
LA  - eng
PT  - Journal Article
DEP - 20140311
PL  - England
TA  - J Asthma
JT  - The Journal of asthma : official journal of the Association for the Care of 
      Asthma
JID - 8106454
RN  - 0 (Biomarkers)
RN  - 0 (OX40 Ligand)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Asthma/*metabolism
MH  - B-Lymphocytes/metabolism
MH  - Biomarkers
MH  - Case-Control Studies
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Flow Cytometry
MH  - Humans
MH  - Hypersensitivity, Immediate/*metabolism
MH  - Immunoglobulin E/immunology
MH  - Male
MH  - Middle Aged
MH  - OX40 Ligand/*biosynthesis
MH  - Respiratory Function Tests
OTO - NOTNLM
OT  - Asthma
OT  - IgE
OT  - OX40L
OT  - T-helper 2
OT  - atopy
OT  - flow cytometry
EDAT- 2014/03/04 06:00
MHDA- 2014/09/10 06:00
CRDT- 2014/03/04 06:00
PHST- 2014/03/04 06:00 [entrez]
PHST- 2014/03/04 06:00 [pubmed]
PHST- 2014/09/10 06:00 [medline]
AID - 10.3109/02770903.2014.897729 [doi]
PST - ppublish
SO  - J Asthma. 2014 Aug;51(6):573-7. doi: 10.3109/02770903.2014.897729. Epub 2014 Mar 
      11.