PMID- 24582395 OWN - NLM STAT- MEDLINE DCOM- 20140726 LR - 20240109 IS - 1873-3778 (Electronic) IS - 0021-9673 (Linking) VI - 1336 DP - 2014 Apr 4 TI - Determination of selected pharmaceutical compounds in biosolids by supported liquid extraction and gas chromatography-tandem mass spectrometry. PG - 52-8 LID - S0021-9673(14)00236-2 [pii] LID - 10.1016/j.chroma.2014.02.020 [doi] AB - In this work, an analytical method was developed for the determination of pharmaceutical drugs in biosolids. Samples were extracted with an acidic mixture of water and acetone (1:2, v/v) and supported liquid extraction was used for the clean-up of extracts, eluting with ethyl acetate:methanol (90:10, v/v). The compounds were determined by gas chromatography-tandem mass spectrometry using matrix-match calibration after silylation to form their t-butyldimethylsilyl derivatives. This method presents various advantages, such as a fairly simple operation for the analysis of complex matrices, the use of inexpensive glassware and low solvent volumes. Satisfactory mean recoveries were obtained with the developed method ranging from 70 to 120% with relative standard deviations (RSDs)