PMID- 24582626
OWN - NLM
STAT- MEDLINE
DCOM- 20141203
LR  - 20140407
IS  - 1872-9754 (Electronic)
IS  - 0197-0186 (Linking)
VI  - 69
DP  - 2014 Apr
TI  - Fluvoxamine moderates reduced voluntary activity following chronic dexamethasone 
      infusion in mice via recovery of BDNF signal cascades.
PG  - 9-13
LID - S0197-0186(14)00032-1 [pii]
LID - 10.1016/j.neuint.2014.02.002 [doi]
AB  - Major depression is a complex disorder characterized by genetic and environmental 
      interactions. Selective serotonin reuptake inhibitors (SSRIs) effectively treat 
      depression. Neurogenesis following chronic antidepressant treatment activates 
      brain derived neurotrophic factor (BDNF) signaling. In this study, we analyzed 
      the effects of the SSRI fluvoxamine (Flu) on locomotor activity and forced-swim 
      behavior using chronic dexamethasone (cDEX) infusions in mice, which engenders 
      depression-like behavior. Infusion of cDEX decreased body weight and produced a 
      trend towards lower locomotor activity during darkness. In the forced-swim test, 
      cDEX-mice exhibited increased immobility times compared with mice administered 
      saline. Flu treatment reversed decreased locomotor activity and mitigated 
      forced-swim test immobility. Real-time polymerase chain reactions using brain RNA 
      samples yielded significantly lower BDNF mRNA levels in cDEX-mice compared with 
      the saline group. Endoplasmic reticulum stress-associated X-box binding protein-1 
      (XBP1) gene expression was lower in cDEX-mice compared with the saline group. 
      However, marked expression of the XBP1 gene was observed in cDEX-mice treated 
      with Flu compared with mice given saline and untreated cDEX-mice. Expression of 
      5-HT2A and Sigma-1 receptors decreased after cDEX infusion compared with the 
      saline group, and these decreases normalized to control levels upon Flu 
      treatment. Our results indicate that the Flu moderates reductions in voluntary 
      activity following chronic dexamethasone infusions in mice via recovery of BDNF 
      signal cascades.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Terada, Kazuki
AU  - Terada K
AD  - Department of Clinical Pharmacology, Faculty of Pharmaceutical Science, Yokohama 
      College of Pharmacy, 601 Matano-cho, Totsuka-ku, Yokohama, Kanagawa 245-0066, 
      Japan; Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, 
      Japan.
FAU - Izumo, Nobuo
AU  - Izumo N
AD  - Department of Clinical Pharmacology, Faculty of Pharmaceutical Science, Yokohama 
      College of Pharmacy, 601 Matano-cho, Totsuka-ku, Yokohama, Kanagawa 245-0066, 
      Japan. Electronic address: n.izumo@hamayaku.ac.jp.
FAU - Suzuki, Biora
AU  - Suzuki B
AD  - Department of Clinical Pharmacology, Faculty of Pharmaceutical Science, Yokohama 
      College of Pharmacy, 601 Matano-cho, Totsuka-ku, Yokohama, Kanagawa 245-0066, 
      Japan.
FAU - Karube, Yoshiharu
AU  - Karube Y
AD  - Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, Japan.
FAU - Morikawa, Tomomi
AU  - Morikawa T
AD  - Division of Gene Expression Mechanisms, Institute for Comprehensive Medical 
      Science, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, 
      Aichi 470-1192, Japan.
FAU - Ishibashi, Yukiko
AU  - Ishibashi Y
AD  - Department of Biochemistry, Faculty of Pharmaceutical Science, Yokohama College 
      of Pharmacy, 601 Matano-cho, Totsuka-Ku, Yokohama, Kanagawa 245-0066, Japan; 
      Division of Development Higher Brain Functions (University of Fukui), United 
      Graduate School of Child Development, Osaka University, Kanazawa University and 
      Hamamatsu University School of Medicine, Chiba University and University of 
      Fukui, Fukui, Japan.
FAU - Kameyama, Toshiki
AU  - Kameyama T
AD  - Division of Gene Expression Mechanisms, Institute for Comprehensive Medical 
      Science, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, 
      Aichi 470-1192, Japan.
FAU - Chiba, Koji
AU  - Chiba K
AD  - Department of Clinical Pharmacology, Faculty of Pharmaceutical Science, Yokohama 
      College of Pharmacy, 601 Matano-cho, Totsuka-ku, Yokohama, Kanagawa 245-0066, 
      Japan.
FAU - Sasaki, Noriko
AU  - Sasaki N
AD  - Division of Gene Expression Mechanisms, Institute for Comprehensive Medical 
      Science, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, 
      Aichi 470-1192, Japan.
FAU - Iwata, Keiko
AU  - Iwata K
AD  - Division of Development Higher Brain Functions (University of Fukui), United 
      Graduate School of Child Development, Osaka University, Kanazawa University and 
      Hamamatsu University School of Medicine, Chiba University and University of 
      Fukui, Fukui, Japan.
FAU - Matsuzaki, Hideo
AU  - Matsuzaki H
AD  - Division of Development Higher Brain Functions (University of Fukui), United 
      Graduate School of Child Development, Osaka University, Kanazawa University and 
      Hamamatsu University School of Medicine, Chiba University and University of 
      Fukui, Fukui, Japan.
FAU - Manabe, Takayuki
AU  - Manabe T
AD  - Division of Gene Expression Mechanisms, Institute for Comprehensive Medical 
      Science, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, 
      Aichi 470-1192, Japan. Electronic address: manabe@fujita-hu.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140228
PL  - England
TA  - Neurochem Int
JT  - Neurochemistry international
JID - 8006959
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7S5I7G3JQL (Dexamethasone)
RN  - O4L1XPO44W (Fluvoxamine)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*pharmacology
MH  - Behavior, Animal
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Depression/*drug therapy
MH  - Dexamethasone/*pharmacology
MH  - Disease Models, Animal
MH  - Fluvoxamine/*pharmacology
MH  - Male
MH  - Mice
MH  - Motor Activity/*drug effects
MH  - Neurogenesis/drug effects
MH  - Signal Transduction/*drug effects
OTO - NOTNLM
OT  - Depression
OT  - Dexamethasone
OT  - Fluvoxamine
OT  - HPA axis
EDAT- 2014/03/04 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/03/04 06:00
PHST- 2013/10/28 00:00 [received]
PHST- 2014/01/31 00:00 [revised]
PHST- 2014/02/14 00:00 [accepted]
PHST- 2014/03/04 06:00 [entrez]
PHST- 2014/03/04 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - S0197-0186(14)00032-1 [pii]
AID - 10.1016/j.neuint.2014.02.002 [doi]
PST - ppublish
SO  - Neurochem Int. 2014 Apr;69:9-13. doi: 10.1016/j.neuint.2014.02.002. Epub 2014 Feb 
      28.