PMID- 24583313
OWN - NLM
STAT- MEDLINE
DCOM- 20140607
LR  - 20140411
IS  - 1879-0631 (Electronic)
IS  - 0024-3205 (Linking)
VI  - 102
IP  - 1
DP  - 2014 Apr 25
TI  - The diabetic vasculature: physiological mechanisms of dysfunction and influence 
      of aerobic exercise training in animal models.
PG  - 1-9
LID - S0024-3205(14)00263-X [pii]
LID - 10.1016/j.lfs.2014.02.021 [doi]
AB  - Diabetes mellitus (DM) is associated with a number of complications of which 
      chronic vascular complications are undoubtedly the most complex and significant 
      consequence. With a significant impact on health care, 50-80% of people with 
      diabetes die of cardiovascular disease (including coronary artery disease, 
      stroke, peripheral vascular disease and other vascular disease), making it the 
      major cause of morbidity and mortality in diabetic patients. A healthy lifestyle 
      is essential in the management of DM, especially the inclusion of aerobic 
      exercise, which has been shown effective in reducing the deleterious effects in 
      vasculature. Interest in exercise studies has increased significantly with 
      promising results that demonstrate a future for investigation. Considering the 
      importance of this emerging field, the aim of this mini-review is to summarize 
      and integrate animal studies investigating physiological mechanisms of vascular 
      dysfunction and remodeling in type 1 diabetes mellitus (T1DM) and type 2 diabetes 
      mellitus (T2DM) and how these are influenced by chronic aerobic exercise 
      training.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Delbin, Maria A
AU  - Delbin MA
AD  - Department of Structural and Functional Biology, Institute of Biology, University 
      of Campinas (UNICAMP), Campinas, SP, Brazil. Electronic address: 
      nadelbin@hotmail.com.
FAU - Trask, Aaron J
AU  - Trask AJ
AD  - Center for Cardiovascular and Pulmonary Research, The Research Institute at 
      Nationwide Children's Hospital, Columbus, OH, USA; The Heart Center, The Research 
      Institute at Nationwide Children's Hospital, Columbus, OH, USA; Department of 
      Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140228
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
SB  - IM
MH  - Animals
MH  - Diabetes Mellitus, Type 1/complications/*physiopathology/therapy
MH  - Diabetes Mellitus, Type 2/complications/*physiopathology/therapy
MH  - Diabetic Angiopathies/epidemiology/prevention & control
MH  - Exercise Therapy/methods
MH  - Humans
MH  - Life Style
MH  - Physical Conditioning, Animal/*physiology
OTO - NOTNLM
OT  - Aerobic exercise training
OT  - Diabetes mellitus
OT  - Vascular remodeling
OT  - Vascular responsiveness
EDAT- 2014/03/04 06:00
MHDA- 2014/06/08 06:00
CRDT- 2014/03/04 06:00
PHST- 2013/10/29 00:00 [received]
PHST- 2014/01/30 00:00 [revised]
PHST- 2014/02/15 00:00 [accepted]
PHST- 2014/03/04 06:00 [entrez]
PHST- 2014/03/04 06:00 [pubmed]
PHST- 2014/06/08 06:00 [medline]
AID - S0024-3205(14)00263-X [pii]
AID - 10.1016/j.lfs.2014.02.021 [doi]
PST - ppublish
SO  - Life Sci. 2014 Apr 25;102(1):1-9. doi: 10.1016/j.lfs.2014.02.021. Epub 2014 Feb 
      28.