PMID- 24583406
OWN - NLM
STAT- MEDLINE
DCOM- 20150106
LR  - 20161125
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Linking)
VI  - 40
IP  - 4
DP  - 2014
TI  - Resting state executive control network adaptations in amnestic mild cognitive 
      impairment.
PG  - 993-1004
LID - 10.3233/JAD-131574 [doi]
AB  - Executive dysfunction is frequently associated with episodic memory decline in 
      amnestic mild cognitive impairment (aMCI) patients. Resting state executive 
      control network (RS-ECN) represents a novel approach to interrogate the integrity 
      of brain areas underlying executive dysfunction. The present study aims to 
      investigate RS-ECN in aMCI and examine a possible link between changes in brain 
      functional connectivity and declines in executive function. aMCI individuals (n = 
      13) and healthy subjects (n = 16) underwent cognitive assessment including 
      executive function and high field functional magnetic resonance imaging. 
      Individual RS-ECN maps were estimated using a seed-based cross-correlation 
      method. Between groups RS-ECN functional connectivity comparison was assessed 
      using voxel-wise statistic parametric mapping. aMCI individuals had reduced 
      RS-ECN connectivity in the anterior cingulate cortex (ACC) and dorsal lateral 
      prefrontal cortex (DLPFC), bilaterally. In contrast, aMCI showed increased 
      connectivity in ventral lateral and anterior prefrontal cortex, bilaterally. 
      Connectivity strength was associated with executive function in the ACC (r = 
      0.6213, p = 0.023) and right DLPFC (r = 0.6454, p = 0.017). Coexistence between 
      connectivity declines and recruitment of brain regions outside the RS-ECN as 
      reported here fits a brain reserve conceptual framework in which brain networks 
      undergo remodeling in aMCI individuals.
FAU - Wu, Liyong
AU  - Wu L
AD  - Translational Neuroimaging Laboratory, Douglas Hospital, McGill University, 
      Montreal, QC, Canada McGill Centre for Studies in Aging (MCSA), McGill 
      University, Montreal, QC, Canada Department of Neurology, Xuan Wu Hospital, 
      Capital Medical University, Beijing, China.
FAU - Soder, Ricardo Bernardi
AU  - Soder RB
AD  - Translational Neuroimaging Laboratory, Douglas Hospital, McGill University, 
      Montreal, QC, Canada McGill Centre for Studies in Aging (MCSA), McGill 
      University, Montreal, QC, Canada McConnell Brain Imaging Centre, Montreal 
      Neurological Institute, Montreal, QC, Canada.
FAU - Schoemaker, Dorothee
AU  - Schoemaker D
AD  - Translational Neuroimaging Laboratory, Douglas Hospital, McGill University, 
      Montreal, QC, Canada McGill Centre for Studies in Aging (MCSA), McGill 
      University, Montreal, QC, Canada.
FAU - Carbonnell, Felix
AU  - Carbonnell F
AD  - McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, QC, 
      Canada.
FAU - Sziklas, Viviane
AU  - Sziklas V
AD  - Department of Psychology, Neuropsychology Unit, McGill University, Montreal, QC, 
      Canada.
FAU - Rowley, Jared
AU  - Rowley J
AD  - Translational Neuroimaging Laboratory, Douglas Hospital, McGill University, 
      Montreal, QC, Canada McGill Centre for Studies in Aging (MCSA), McGill 
      University, Montreal, QC, Canada.
FAU - Mohades, Sara
AU  - Mohades S
AD  - Translational Neuroimaging Laboratory, Douglas Hospital, McGill University, 
      Montreal, QC, Canada McGill Centre for Studies in Aging (MCSA), McGill 
      University, Montreal, QC, Canada.
FAU - Fonov, Vladmir
AU  - Fonov V
AD  - McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, QC, 
      Canada.
FAU - Bellec, Pierre
AU  - Bellec P
AD  - McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, QC, 
      Canada.
FAU - Dagher, Alain
AU  - Dagher A
AD  - McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, QC, 
      Canada.
FAU - Shmuel, Amir
AU  - Shmuel A
AD  - McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, QC, 
      Canada.
FAU - Jia, Jianping
AU  - Jia J
AD  - Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, 
      China.
FAU - Gauthier, Serge
AU  - Gauthier S
AD  - McGill Centre for Studies in Aging (MCSA), McGill University, Montreal, QC, 
      Canada.
FAU - Rosa-Neto, Pedro
AU  - Rosa-Neto P
AD  - Translational Neuroimaging Laboratory, Douglas Hospital, McGill University, 
      Montreal, QC, Canada McGill Centre for Studies in Aging (MCSA), McGill 
      University, Montreal, QC, Canada McConnell Brain Imaging Centre, Montreal 
      Neurological Institute, Montreal, QC, Canada.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Aged
MH  - Amnesia/complications
MH  - *Brain Mapping
MH  - Cerebral Cortex/*blood supply/pathology
MH  - Cognitive Dysfunction/etiology/*pathology
MH  - Executive Function/*physiology
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Mental Status Schedule
MH  - Middle Aged
MH  - Nerve Net/*blood supply
MH  - Neuropsychological Tests
MH  - Oxygen/blood
MH  - *Rest
OTO - NOTNLM
OT  - Executive control network
OT  - executive function
OT  - functional MRI
OT  - mild cognitive impairment
OT  - neural plasticity
EDAT- 2014/03/04 06:00
MHDA- 2015/01/07 06:00
CRDT- 2014/03/04 06:00
PHST- 2014/03/04 06:00 [entrez]
PHST- 2014/03/04 06:00 [pubmed]
PHST- 2015/01/07 06:00 [medline]
AID - D518M2612J0P8024 [pii]
AID - 10.3233/JAD-131574 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2014;40(4):993-1004. doi: 10.3233/JAD-131574.