PMID- 24583837
OWN - NLM
STAT- MEDLINE
DCOM- 20150602
LR  - 20181202
IS  - 1940-2465 (Electronic)
IS  - 1066-8969 (Linking)
VI  - 22
IP  - 7
DP  - 2014 Oct
TI  - ALK-positive inflammatory myofibroblastic tumor of the abdomen with widespread 
      microscopic multifocality.
PG  - 640-4
LID - 10.1177/1066896914525232 [doi]
AB  - Inflammatory myofibroblastic tumor (IMT) is a locally aggressive neoplasm, most 
      frequently occurring in the abdominal cavity as multiple recurrent nodules. We 
      report a case of IMT in a 24-year-old male presenting as multiple nodules 
      involving the omentum, the liver, and the colon. Spindle tumor cells expressed 
      ALK with a cytoplasmic granular distribution, the CLTC-ALK fusion gene was 
      demonstrated by reverse-transcriptase polymerase chain reaction analysis, and 
      break-apart fluorescence in situ hybridization (FISH) probes for the ALK gene 
      showed a pathological pattern (single red signal associated with 1/2 normal fused 
      signals) highly suggestive for combined gene fusion and deletion. To reduce the 
      surgically unresectable liver mass, the patient was treated with crizotinib, and 
      after 4 months of treatment the disease was defined stable according to RECIST 
      criteria. Interestingly, ALK and FISH/FICTION analysis revealed that tumor cells 
      were widely dispersed as multiple microscopic foci or as single cells beneath the 
      omental mesothelium. These findings indicate that IMT multifocality might result 
      either from dissemination from the main tumor mass or development of multiple 
      independent neoplastic foci; furthermore, they underline the need of omentectomy 
      in abdominal IMT to obtain surgical radicality.
CI  - (c) The Author(s) 2014.
FAU - Lorenzi, Luisa
AU  - Lorenzi L
AD  - Pathology Section, Department of Molecular and Translational Medicine, University 
      of Brescia, Spedali Civili, Brescia, Italy.
FAU - Cigognetti, Marta
AU  - Cigognetti M
AD  - Pathology Section, Department of Molecular and Translational Medicine, University 
      of Brescia, Spedali Civili, Brescia, Italy.
FAU - Medicina, Daniela
AU  - Medicina D
AD  - Pathology Section, Department of Molecular and Translational Medicine, University 
      of Brescia, Spedali Civili, Brescia, Italy.
FAU - Pellegrini, Vilma
AU  - Pellegrini V
AD  - Pathology Section, Department of Molecular and Translational Medicine, University 
      of Brescia, Spedali Civili, Brescia, Italy.
FAU - Balzarini, Piera
AU  - Balzarini P
AD  - Pathology Section, Department of Molecular and Translational Medicine, University 
      of Brescia, Spedali Civili, Brescia, Italy.
FAU - Cestari, Renzo
AU  - Cestari R
AD  - Digestive Endoscopy, Department of Clinical and Experimental Sciences, University 
      of Brescia, Spedali Civili, Brescia, Italy.
FAU - Facchetti, Fabio
AU  - Facchetti F
AD  - Pathology Section, Department of Molecular and Translational Medicine, University 
      of Brescia, Spedali Civili, Brescia, Italy facchett@med.unibs.it.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140228
PL  - United States
TA  - Int J Surg Pathol
JT  - International journal of surgical pathology
JID - 9314927
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (oncoprotein CLTCL-ALK)
RN  - EC 2.7.10.1 (ALK protein, human)
RN  - EC 2.7.10.1 (Anaplastic Lymphoma Kinase)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - Abdominal Neoplasms/genetics/*pathology
MH  - Anaplastic Lymphoma Kinase
MH  - Biomarkers, Tumor/analysis
MH  - Colonic Neoplasms/secondary
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Liver Neoplasms/secondary
MH  - Male
MH  - Neoplasms, Muscle Tissue/genetics/*secondary
MH  - Omentum/pathology
MH  - Oncogene Proteins, Fusion/*genetics
MH  - Receptor Protein-Tyrosine Kinases/analysis/biosynthesis
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Young Adult
OTO - NOTNLM
OT  - ALK
OT  - inflammatory myofibroblastic tumor
OT  - microscopic multifocality
OT  - omentum
EDAT- 2014/03/04 06:00
MHDA- 2015/06/03 06:00
CRDT- 2014/03/04 06:00
PHST- 2014/03/04 06:00 [entrez]
PHST- 2014/03/04 06:00 [pubmed]
PHST- 2015/06/03 06:00 [medline]
AID - 1066896914525232 [pii]
AID - 10.1177/1066896914525232 [doi]
PST - ppublish
SO  - Int J Surg Pathol. 2014 Oct;22(7):640-4. doi: 10.1177/1066896914525232. Epub 2014 
      Feb 28.