PMID- 24584819
OWN - NLM
STAT- MEDLINE
DCOM- 20141124
LR  - 20211021
IS  - 1573-6903 (Electronic)
IS  - 0364-3190 (Linking)
VI  - 39
IP  - 4
DP  - 2014 Apr
TI  - Subchronic oral administration of Benzo[a]pyrene impairs motor and cognitive 
      behavior and modulates S100B levels and MAPKs in rats.
PG  - 731-40
LID - 10.1007/s11064-014-1261-y [doi]
AB  - Benzo[a]pyrene (BaP) is an environmental contaminant produced during incomplete 
      combustion of organic material that is well known as a mutagenic and carcinogenic 
      toxin. There are few studies addressing the molecular and cellular basis of 
      behavioural alterations related to BaP exposure. The aim of this study was to 
      evaluate the effect of subchronic oral administration of BaP on behavioral and 
      neurochemical parameters. Wistar male rats received BaP (2 mg/kg) or corn oil 
      (control), once a day for 28 days (n = 12/group). Spontaneous locomotor activity 
      and short- and long-term memories were evaluated. Glial fibrillary acid protein 
      and S100B content in the hippocampus, serum and CSF were measured using ELISA and 
      total and phosphorylated forms of mitogen activated protein kinases (MAPKs) named 
      extracellular signal-regulated kinases 1 and 2, p38(MAPK) and c-Jun 
      amino-terminal kinases 1 and 2, in the hippocampus, were evaluated by western 
      blotting. BaP induced a significant increase on locomotor activity and a decrease 
      in short-term memory. S100B content was increased significantly in cerebrospinal 
      fluid. BaP induced a decrease on ERK2 phosphorylation in the hippocampus. Thus, 
      BaP subchronic treatment induces an astroglial response and impairs both motor 
      and cognitive behavior, with parallel inhibition of ERK2, a signaling enzyme 
      involved in the hippocampal neuroplasticity. All these effects suggest that BaP 
      neurotoxicity is a concern for environmental pollution.
FAU - Maciel, Erica Santos
AU  - Maciel ES
AD  - Programa de Pos Graduacao em Ciencias Biologicas - Neurociencias, Instituto de 
      Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Rua 
      Sarmento Leite, 500/107, Porto Alegre, RS, 90050-170, Brazil.
FAU - Biasibetti, Regina
AU  - Biasibetti R
FAU - Costa, Ana Paula
AU  - Costa AP
FAU - Lunardi, Paula
AU  - Lunardi P
FAU - Schunck, Rebeca Vargas Antunes
AU  - Schunck RV
FAU - Becker, Gabriela Curbeti
AU  - Becker GC
FAU - Arbo, Marcelo Dutra
AU  - Arbo MD
FAU - Dallegrave, Eliane
AU  - Dallegrave E
FAU - Goncalves, Carlos Alberto
AU  - Goncalves CA
FAU - Saldiva, Paulo H Nascimento
AU  - Saldiva PH
FAU - Garcia, Solange Cristina
AU  - Garcia SC
FAU - Leal, Rodrigo Bainy
AU  - Leal RB
FAU - Leal, Mirna Bainy
AU  - Leal MB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140302
PL  - United States
TA  - Neurochem Res
JT  - Neurochemical research
JID - 7613461
RN  - 0 (S100 Calcium Binding Protein beta Subunit)
RN  - 0 (S100b protein, rat)
RN  - 3417WMA06D (Benzo(a)pyrene)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Benzo(a)pyrene/administration & dosage/*toxicity
MH  - Cognition/drug effects/*physiology
MH  - Hippocampus/drug effects/metabolism
MH  - Male
MH  - Mitogen-Activated Protein Kinases/*metabolism
MH  - Motor Activity/drug effects/*physiology
MH  - Psychomotor Performance/drug effects/physiology
MH  - Rats
MH  - Rats, Wistar
MH  - S100 Calcium Binding Protein beta Subunit/*metabolism
EDAT- 2014/03/04 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/03/04 06:00
PHST- 2013/12/18 00:00 [received]
PHST- 2014/02/15 00:00 [accepted]
PHST- 2014/02/14 00:00 [revised]
PHST- 2014/03/04 06:00 [entrez]
PHST- 2014/03/04 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - 10.1007/s11064-014-1261-y [doi]
PST - ppublish
SO  - Neurochem Res. 2014 Apr;39(4):731-40. doi: 10.1007/s11064-014-1261-y. Epub 2014 
      Mar 2.