PMID- 2458534
OWN - NLM
STAT- MEDLINE
DCOM- 19881024
LR  - 20190726
IS  - 0028-3908 (Print)
IS  - 0028-3908 (Linking)
VI  - 27
IP  - 7
DP  - 1988 Jul
TI  - Increased plasma catecholamines and locomotor activity induced by centrally 
      administered substance P in guinea-pigs.
PG  - 743-8
AB  - The effects on locomotor activity and plasma catecholamines of substance P, 0.5 
      nmol, injected into each lateral ventricle (i.c.v.), or 1 nmol, injected into the 
      cisterna magna of conscious guinea-pigs, were investigated. Locomotor activity 
      was measured in cages fitted with an infra-red photocell and detector, and plasma 
      catecholamines, were measured by HPLC with electrochemical detection. Substance 
      P, given intraventricularly or into the cisterna magna, produced increased 
      locomotor activity and a pattern of behavioural activity which mimicked the 
      opiate withdrawal response, found in previous studies in this species. Levels of 
      NA and AD in plasma were also significantly elevated after injection of substance 
      P. These effects of substance P were relatively long-lasting, since they were 
      present up to 1 hr after injection. The results show that the effects of 
      centrally administered substance P in guinea-pigs are similar to those in rats. 
      Furthermore, the results support the suggestion that substance P might be the 
      mediator of the opiate withdrawal response in the central nervous system as has 
      been proposed for the enteric nervous system.
FAU - Brent, P J
AU  - Brent PJ
AD  - Discipline of Clinical Pharmacology, Faculty of Medicine, University of 
      Newcastle, N.S.W., Australia.
FAU - Johnston, P A
AU  - Johnston PA
FAU - Chahl, L A
AU  - Chahl LA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
RN  - 33507-63-0 (Substance P)
RN  - X4W3ENH1CV (Norepinephrine)
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Animals
MH  - Cisterna Magna
MH  - Epinephrine/*blood
MH  - Female
MH  - Guinea Pigs
MH  - Injections
MH  - Male
MH  - Motor Activity/*drug effects
MH  - Norepinephrine/*blood
MH  - Substance P/*pharmacology
EDAT- 1988/07/01 00:00
MHDA- 1988/07/01 00:01
CRDT- 1988/07/01 00:00
PHST- 1988/07/01 00:00 [pubmed]
PHST- 1988/07/01 00:01 [medline]
PHST- 1988/07/01 00:00 [entrez]
AID - 10.1016/0028-3908(88)90084-6 [doi]
PST - ppublish
SO  - Neuropharmacology. 1988 Jul;27(7):743-8. doi: 10.1016/0028-3908(88)90084-6.