PMID- 24585461
OWN - NLM
STAT- MEDLINE
DCOM- 20150305
LR  - 20171116
IS  - 1613-4133 (Electronic)
IS  - 1613-4125 (Linking)
VI  - 58
IP  - 7
DP  - 2014 Jul
TI  - Glycyrrhizic acid attenuated glycative stress in kidney of diabetic mice through 
      enhancing glyoxalase pathway.
PG  - 1426-35
LID - 10.1002/mnfr.201300910 [doi]
AB  - SCOPE: Antiglycative effects of glycyrrhizic acid (GA) in kidney of diabetic mice 
      were examined. METHODS AND RESULTS: GA at 0.05, 0.1, and 0.2% was supplied to 
      diabetic mice for 9 wk. Results showed that GA intake increased its deposit in 
      kidney, raised plasma insulin level, decreased plasma glucose and blood urine 
      nitrogen levels, and improved creatinine clearance rate (p < 0.05). GA intake 
      dose-dependently reduced renal carboxymethyllysine level, and at 0.1 and 0.2% 
      decreased plasma HbA1c, urinary glycated albumin, and renal pentosidine levels (p 
      < 0.05). Dietary GA intake declined renal aldose reductase activity and protein 
      expression, as well as lowered renal fructose and sorbitol levels (p < 0.05). GA 
      intake dose-dependently increased glyoxalase-1 activity and expression, and 
      decreased renal methylglyoxal level (p < 0.05). This compound at 0.1 and 0.2% 
      raised glyoxalase-2 activity and protein expression, and increased d-lactate 
      formation (p < 0.05). GA intake dose-dependently suppressed renal expression of 
      nuclear factor kappa B (NF-kappaB) p65 and p-p38, decreased reactive oxygen species 
      production, and retained glutathione content (p < 0.05). This compound at 0.1 and 
      0.2% downregulated renal expression of NF-kappaB p50 and p-ERK1/2 (p < 0.05), and 
      lowered renal level of monocyte chemoattractant protein-1 (MCP-1) and 
      intercellular adhesion molecule-1 (ICAM-1). CONCLUSIONS: These findings suggest 
      that glycyrrhizic acid is an antiglycative and renal-protective agent.
CI  - (c) 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Wang, Zhi-hong
AU  - Wang ZH
AD  - Center of Aging Research, China Medical University Hospital, Taichung City, 
      Taiwan.
FAU - Hsieh, Cheng-Hong
AU  - Hsieh CH
FAU - Liu, Wen-hu
AU  - Liu WH
FAU - Yin, Mei-chin
AU  - Yin MC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140303
PL  - Germany
TA  - Mol Nutr Food Res
JT  - Molecular nutrition & food research
JID - 101231818
RN  - 0 (Ccl2 protein, mouse)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Icam1 protein, mouse)
RN  - 0 (NF-kappa B)
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Receptor for Advanced Glycation End Products)
RN  - 0 (Receptors, Immunologic)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - 30237-26-4 (Fructose)
RN  - 506T60A25R (Sorbitol)
RN  - 6FO62043WK (Glycyrrhizic Acid)
RN  - EC 1.1.1.14 (L-Iditol 2-Dehydrogenase)
RN  - EC 1.1.1.21 (Aldehyde Reductase)
RN  - EC 3.1.2.- (Thiolester Hydrolases)
RN  - EC 3.1.2.6 (hydroxyacylglutathione hydrolase)
RN  - EC 4.4.1.5 (Lactoylglutathione Lyase)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Aldehyde Reductase/genetics/metabolism
MH  - Animals
MH  - Chemokine CCL2/genetics/metabolism
MH  - Diabetes Mellitus, Experimental/*drug therapy
MH  - Dose-Response Relationship, Drug
MH  - Fructose/urine
MH  - Glutathione/metabolism
MH  - Glycyrrhizic Acid/*pharmacology
MH  - Intercellular Adhesion Molecule-1/genetics/metabolism
MH  - Kidney/*drug effects/metabolism
MH  - L-Iditol 2-Dehydrogenase/metabolism
MH  - Lactoylglutathione Lyase/genetics/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - NF-kappa B/genetics/metabolism
MH  - Oxidative Stress/*drug effects
MH  - Reactive Oxygen Species/metabolism
MH  - Receptor for Advanced Glycation End Products
MH  - Receptors, Immunologic/genetics/metabolism
MH  - Sorbitol/urine
MH  - Thiolester Hydrolases/genetics/metabolism
OTO - NOTNLM
OT  - Diabetic nephropathy
OT  - Glycation
OT  - Glycyrrhizic acid
OT  - Glyoxalase-1
OT  - Methylglyoxal
EDAT- 2014/03/04 06:00
MHDA- 2015/03/07 06:00
CRDT- 2014/03/04 06:00
PHST- 2013/11/30 00:00 [received]
PHST- 2014/01/19 00:00 [revised]
PHST- 2014/02/02 00:00 [accepted]
PHST- 2014/03/04 06:00 [entrez]
PHST- 2014/03/04 06:00 [pubmed]
PHST- 2015/03/07 06:00 [medline]
AID - 10.1002/mnfr.201300910 [doi]
PST - ppublish
SO  - Mol Nutr Food Res. 2014 Jul;58(7):1426-35. doi: 10.1002/mnfr.201300910. Epub 2014 
      Mar 3.