PMID- 24586380
OWN - NLM
STAT- MEDLINE
DCOM- 20150109
LR  - 20231110
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 2
DP  - 2014
TI  - Preservation of general intelligence following traumatic brain injury: 
      contributions of the Met66 brain-derived neurotrophic factor.
PG  - e88733
LID - 10.1371/journal.pone.0088733 [doi]
LID - e88733
AB  - Brain-derived neurotrophic factor (BDNF) promotes survival and synaptic 
      plasticity in the human brain. The Val66Met polymorphism of the BDNF gene 
      interferes with intracellular trafficking, packaging, and regulated secretion of 
      this neurotrophin. The human prefrontal cortex (PFC) shows lifelong neuroplastic 
      adaption implicating the Val66Met BDNF polymorphism in the recovery of 
      higher-order executive functions after traumatic brain injury (TBI). In this 
      study, we examined the effect of this BDNF polymorphism on the preservation of 
      general intelligence following TBI. We genotyped a sample of male Vietnam combat 
      veterans (n = 156) consisting of a frontal lobe lesion group with focal 
      penetrating head injuries for the Val66Met BDNF polymorphism. Val/Met did not 
      differ from Val/Val genotypes in general cognitive ability before TBI. However, 
      we found substantial average differences between these groups in general 
      intelligence ( approximately  half a standard deviation or 8 IQ points), verbal comprehension 
      (6 IQ points), perceptual organization (6 IQ points), working memory (8 IQ 
      points), and processing speed (8 IQ points) after TBI. These results support the 
      conclusion that Val/Met genotypes preserve general cognitive functioning, whereas 
      Val/Val genotypes are largely susceptible to TBI.
FAU - Barbey, Aron K
AU  - Barbey AK
AD  - Decision Neuroscience Laboratory, University of Illinois, Urbana, Illinois, 
      United States of America ; Beckman Institute for Advanced Science and Technology, 
      University of Illinois, Urbana, Illinois, United States of America ; Department 
      of Internal Medicine, University of Illinois, Champaign, Illinois, United States 
      of America ; Department of Psychology, University of Illinois, Champaign, 
      Illinois, United States of America ; Department of Speech and Hearing Science, 
      University of Illinois, Champaign, Illinois, United States of America ; 
      Neuroscience Program, University of Illinois, Champaign, Illinois, United States 
      of America.
FAU - Colom, Roberto
AU  - Colom R
AD  - Universidad Autonoma de Madrid, Fundacion CIEN/Fundacion Reina Sofia, Madrid, 
      Spain.
FAU - Paul, Erick
AU  - Paul E
AD  - Decision Neuroscience Laboratory, University of Illinois, Urbana, Illinois, 
      United States of America ; Beckman Institute for Advanced Science and Technology, 
      University of Illinois, Urbana, Illinois, United States of America.
FAU - Forbes, Chad
AU  - Forbes C
AD  - Department of Psychology, University of Delaware, Delaware, Maryland, United 
      States of America.
FAU - Krueger, Frank
AU  - Krueger F
AD  - Department of Molecular Neuroscience, George Mason University, Virginia, United 
      States of America.
FAU - Goldman, David
AU  - Goldman D
AD  - Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, 
      National Institutes of Health, Bethesda, Maryland, United States of America.
FAU - Grafman, Jordan
AU  - Grafman J
AD  - Traumatic Brain Injury Research Laboratory, Rehabilitation Institute of Chicago, 
      Chicago, Illinois, United States of America.
LA  - eng
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20140226
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
SB  - IM
MH  - Aged
MH  - Brain Injuries/physiopathology/*psychology
MH  - Brain-Derived Neurotrophic Factor/chemistry/genetics/*physiology
MH  - Humans
MH  - *Intelligence
MH  - Male
MH  - Methionine/*chemistry
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Polymorphism, Single Nucleotide
PMC - PMC3935849
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2014/03/04 06:00
MHDA- 2015/01/13 06:00
PMCR- 2014/02/26
CRDT- 2014/03/04 06:00
PHST- 2013/10/30 00:00 [received]
PHST- 2014/01/10 00:00 [accepted]
PHST- 2014/03/04 06:00 [entrez]
PHST- 2014/03/04 06:00 [pubmed]
PHST- 2015/01/13 06:00 [medline]
PHST- 2014/02/26 00:00 [pmc-release]
AID - PONE-D-13-44492 [pii]
AID - 10.1371/journal.pone.0088733 [doi]
PST - epublish
SO  - PLoS One. 2014 Feb 26;9(2):e88733. doi: 10.1371/journal.pone.0088733. eCollection 
      2014.