PMID- 24586790
OWN - NLM
STAT- MEDLINE
DCOM- 20141222
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 2
DP  - 2014
TI  - Decreased plasma brain-derived neurotrophic factor and vascular endothelial 
      growth factor concentrations during military training.
PG  - e89455
LID - 10.1371/journal.pone.0089455 [doi]
LID - e89455
AB  - Decreased concentrations of plasma brain-derived neurotrophic factor (BDNF) and 
      serum BDNF have been proposed to be a state marker of depression and a biological 
      indicator of loaded psychosocial stress. Stress evaluations of participants in 
      military mission are critically important and appropriate objective biological 
      parameters that evaluate stress are needed. In military circumstances, there are 
      several problems to adopt plasma BDNF concentration as a stress biomarker. First, 
      in addition to psychosocial stress, military missions inevitably involve physical 
      exercise that increases plasma BDNF concentrations. Second, most participants in 
      the mission do not have adequate quality or quantity of sleep, and sleep 
      deprivation has also been reported to increase plasma BDNF concentration. We 
      evaluated plasma BDNF concentrations in 52 participants on a 9-week military 
      mission. The present study revealed that plasma BDNF concentration significantly 
      decreased despite elevated serum enzymes that escaped from muscle and decreased 
      quantity and quality of sleep, as detected by a wearable watch-type sensor. In 
      addition, we observed a significant decrease in plasma vascular endothelial 
      growth factor (VEGF) during the mission. VEGF is also neurotrophic and its 
      expression in the brain has been reported to be up-regulated by antidepressive 
      treatments and down-regulated by stress. This is the first report of decreased 
      plasma VEGF concentrations by stress. We conclude that decreased plasma 
      concentrations of neurotrophins can be candidates for mental stress indicators in 
      actual stressful environments that include physical exercise and limited sleep.
FAU - Suzuki, Go
AU  - Suzuki G
AD  - Military Medicine Research Unit, Test and Evaluation Command, Japan Ground Self 
      Defense Force, Setagaya, Setagaya, Tokyo, Japan ; Department of Psychiatry, Japan 
      Self-Defense Force Central Hospital, Setagaya, Setagaya, Tokyo, Japan.
FAU - Tokuno, Shinichi
AU  - Tokuno S
AD  - Department of Defense Medicine, National Defense Medical College, Tokorozawa, 
      Saitama, Japan.
FAU - Nibuya, Masashi
AU  - Nibuya M
AD  - Department of Psychiatry, National Defense Medical College, Tokorozawa, Saitama, 
      Japan.
FAU - Ishida, Toru
AU  - Ishida T
AD  - Military Medicine Research Unit, Test and Evaluation Command, Japan Ground Self 
      Defense Force, Setagaya, Setagaya, Tokyo, Japan.
FAU - Yamamoto, Tetsuo
AU  - Yamamoto T
AD  - Military Medicine Research Unit, Test and Evaluation Command, Japan Ground Self 
      Defense Force, Setagaya, Setagaya, Tokyo, Japan.
FAU - Mukai, Yasuo
AU  - Mukai Y
AD  - Military Medicine Research Unit, Test and Evaluation Command, Japan Ground Self 
      Defense Force, Setagaya, Setagaya, Tokyo, Japan.
FAU - Mitani, Keiji
AU  - Mitani K
AD  - Department of Internal medicine, Japan Self-Defense Force Central Hospital, 
      Setagaya, Setagaya, Tokyo, Japan.
FAU - Tsumatori, Gentaro
AU  - Tsumatori G
AD  - Department of Defense Medicine, National Defense Medical College, Tokorozawa, 
      Saitama, Japan.
FAU - Scott, Daniel
AU  - Scott D
AD  - Division of Molecular Psychiatry, Department of Psychiatry, Yale University 
      School of Medicine, New Haven, Connecticut, United States of America.
FAU - Shimizu, Kunio
AU  - Shimizu K
AD  - Division of Behavioral Sciences, National Defense Medical College Research 
      Institute, Tokorozawa, Saitama, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140224
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Antidepressive Agents/therapeutic use
MH  - Brain-Derived Neurotrophic Factor/*blood/genetics
MH  - Depressive Disorder/blood/drug therapy/genetics
MH  - Down-Regulation/genetics
MH  - Exercise/*physiology/*psychology
MH  - Humans
MH  - Military Personnel/*psychology
MH  - Sleep Deprivation/blood/genetics
MH  - Stress, Psychological/blood/genetics
MH  - Up-Regulation/genetics
MH  - Vascular Endothelial Growth Factor A/*blood/genetics
PMC - PMC3933459
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2014/03/04 06:00
MHDA- 2014/12/23 06:00
PMCR- 2014/02/24
CRDT- 2014/03/04 06:00
PHST- 2013/11/04 00:00 [received]
PHST- 2014/01/20 00:00 [accepted]
PHST- 2014/03/04 06:00 [entrez]
PHST- 2014/03/04 06:00 [pubmed]
PHST- 2014/12/23 06:00 [medline]
PHST- 2014/02/24 00:00 [pmc-release]
AID - PONE-D-13-45063 [pii]
AID - 10.1371/journal.pone.0089455 [doi]
PST - epublish
SO  - PLoS One. 2014 Feb 24;9(2):e89455. doi: 10.1371/journal.pone.0089455. eCollection 
      2014.