PMID- 24586822
OWN - NLM
STAT- MEDLINE
DCOM- 20150303
LR  - 20220409
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 2
DP  - 2014
TI  - Altered spontaneous brain activity in primary open angle glaucoma: a 
      resting-state functional magnetic resonance imaging study.
PG  - e89493
LID - 10.1371/journal.pone.0089493 [doi]
LID - e89493
AB  - BACKGROUND: Previous studies demonstrated that primary open angle glaucoma (POAG) 
      is associated with abnormal brain structure; however, little is known about the 
      changes in the local synchronization of spontaneous activity. The main objective 
      of this study was to investigate spontaneous brain activity in patients with POAG 
      using regional homogeneity (ReHo) analysis based on resting state functional 
      magnetic resonance imaging (rs-fMRI). METHODOLOGY/PRINCIPAL FINDINGS: Thirty-nine 
      POAG patients and forty-one age- and gender- matched healthy controls were 
      finally included in the study. ReHo values were used to evaluate spontaneous 
      brain activity and whole brain voxel-wise analysis of ReHo was carried out to 
      detect differences by region in spontaneous brain activity between groups. 
      Compared to controls, POAG patients showed increased ReHo in the right dorsal 
      anterior cingulated cortex, the bilateral medial frontal gyrus and the right 
      cerebellar anterior lobe, and decreased ReHo in the bilateral calcarine, 
      bilateral precuneus gryus, bilateral pre/postcentral gyrus, left inferior 
      parietal lobule and left cerebellum posterior lobe. A multiple linear regression 
      analysis was performed to explore the relationships between clinical measures and 
      ReHo by region showed significant group differences in the POAG group. Negative 
      correlations were found between age and the ReHo values of the superior frontal 
      gyrus (r = -0.323, p = 0.045), left calcarine (r = -0.357, p = 0.026) and 
      inferior parietal lobule (r = -0.362, p = 0.024). A negative correlation was 
      found between the ReHo values of the left precuneus and the cumulative mean 
      defect (r = -0.400, p = 0.012). CONCLUSIONS: POAG was associated with abnormal 
      brain spontaneous activity in some brain regions and such changed regional 
      activity may be associated with clinical parameters. Spontaneous brain activity 
      may play a role in POAG initiation and progression.
FAU - Song, Yinwei
AU  - Song Y
AD  - Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Mu, Ketao
AU  - Mu K
AD  - Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Wang, Junming
AU  - Wang J
AD  - Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Lin, Fuchun
AU  - Lin F
AD  - Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance 
      and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, 
      Chinese Academy of Sciences, Wuhan, China.
FAU - Chen, Zhiqi
AU  - Chen Z
AD  - Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Yan, Xiaoqin
AU  - Yan X
AD  - Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Hao, Yonghong
AU  - Hao Y
AD  - Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Zhu, Wenzhen
AU  - Zhu W
AD  - Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Zhang, Hong
AU  - Zhang H
AD  - Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140224
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adult
MH  - Brain/*pathology
MH  - Brain Mapping
MH  - Case-Control Studies
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Glaucoma, Open-Angle/*pathology
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Prognosis
MH  - Prospective Studies
MH  - Resting Phase, Cell Cycle/*physiology
PMC - PMC3933564
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2014/03/04 06:00
MHDA- 2015/03/04 06:00
PMCR- 2014/02/24
CRDT- 2014/03/04 06:00
PHST- 2013/09/14 00:00 [received]
PHST- 2014/01/22 00:00 [accepted]
PHST- 2014/03/04 06:00 [entrez]
PHST- 2014/03/04 06:00 [pubmed]
PHST- 2015/03/04 06:00 [medline]
PHST- 2014/02/24 00:00 [pmc-release]
AID - PONE-D-13-37794 [pii]
AID - 10.1371/journal.pone.0089493 [doi]
PST - epublish
SO  - PLoS One. 2014 Feb 24;9(2):e89493. doi: 10.1371/journal.pone.0089493. eCollection 
      2014.