PMID- 24587184
OWN - NLM
STAT- MEDLINE
DCOM- 20141028
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 2
DP  - 2014
TI  - Evaluation of the dosimetric feasibility of hippocampal sparing 
      intensity-modulated radiotherapy in patients with locally advanced nasopharyngeal 
      carcinoma.
PG  - e90007
LID - 10.1371/journal.pone.0090007 [doi]
LID - e90007
AB  - PURPOSE: The objective of this study was to evaluate the dosimetric feasibility 
      of using hippocampus (HPC) sparing intensity-modulated radiotherapy (IMRT) in 
      patients with locally advanced nasopharyngeal carcinoma (NPC). MATERIALS/METHODS: 
      Eight cases of either T3 or T4 NPC were selected for this study. Standard IMRT 
      treatment plans were constructed using the volume and dose constraints for the 
      targets and organs at risk (OAR) per Radiation Therapy Oncology Group (RTOG) 0615 
      protocol. Experimental plans were constructed using the same criteria, with the 
      addition of the HPC as an OAR. The two dose-volume histograms for each case were 
      compared for the targets and OARs. RESULTS: All plans achieved the protocol dose 
      criteria. The homogeneity index, conformity index, and coverage index for the 
      planning target volumes (PTVs) were not significantly compromised by the 
      avoidance of the HPC. The doses to all OARs, excluding the HPC, were similar. 
      Both the dose (Dmax, D2%, D40%, D mean, D median, D98% and D min) and volume (V5, 
      V10, V15, V20, V30, V40 and V50) parameters for the HPC were significantly lower 
      in the HPC sparing plans (p<0.05), except for D min (P = 0.06) and V5 (P = 0.12). 
      CONCLUSIONS: IMRT for patients with locally advanced NPC exposes the HPC to a 
      significant radiation dose. HPC sparing IMRT planning significantly decreases 
      this dose, with minimal impact on the therapeutic targets and other OARs.
FAU - Han, Guang
AU  - Han G
AD  - Department of Radiation Oncology, Hubei Cancer Hospital, Wuhan, PR China.
FAU - Liu, Dong
AU  - Liu D
AD  - Department of Radiation Oncology, Hubei Cancer Hospital, Wuhan, PR China.
FAU - Gan, Hua
AU  - Gan H
AD  - Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, 
      Nebraska, United States of America.
FAU - Denniston, Kyle A
AU  - Denniston KA
AD  - Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, 
      Nebraska, United States of America.
FAU - Li, Sicong
AU  - Li S
AD  - Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, 
      Nebraska, United States of America.
FAU - Tan, Wenyong
AU  - Tan W
AD  - Department of Radiation Oncology, Hubei Cancer Hospital, Wuhan, PR China.
FAU - Hu, Desheng
AU  - Hu D
AD  - Department of Radiation Oncology, Hubei Cancer Hospital, Wuhan, PR China.
FAU - Zhen, Weining
AU  - Zhen W
AD  - Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, 
      Nebraska, United States of America.
FAU - Wang, Zhaohua
AU  - Wang Z
AD  - Department of Radiation Oncology, Hubei Cancer Hospital, Wuhan, PR China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140228
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Carcinoma
MH  - Hippocampus
MH  - Humans
MH  - Nasopharyngeal Carcinoma
MH  - Nasopharyngeal Neoplasms/pathology/*radiotherapy
MH  - Neoplasm Staging
MH  - Organ Sparing Treatments/*methods
MH  - Organs at Risk
MH  - Radiometry
MH  - Radiotherapy Dosage
MH  - *Radiotherapy Planning, Computer-Assisted
MH  - Radiotherapy, Intensity-Modulated/*methods
PMC - PMC3938567
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2014/03/04 06:00
MHDA- 2014/10/29 06:00
PMCR- 2014/02/28
CRDT- 2014/03/04 06:00
PHST- 2013/12/11 00:00 [received]
PHST- 2014/01/24 00:00 [accepted]
PHST- 2014/03/04 06:00 [entrez]
PHST- 2014/03/04 06:00 [pubmed]
PHST- 2014/10/29 06:00 [medline]
PHST- 2014/02/28 00:00 [pmc-release]
AID - PONE-D-13-52010 [pii]
AID - 10.1371/journal.pone.0090007 [doi]
PST - epublish
SO  - PLoS One. 2014 Feb 28;9(2):e90007. doi: 10.1371/journal.pone.0090007. eCollection 
      2014.