PMID- 24588120
OWN - NLM
STAT- MEDLINE
DCOM- 20150703
LR  - 20191027
IS  - 1875-6638 (Electronic)
IS  - 1573-4064 (Linking)
VI  - 10
IP  - 7
DP  - 2014
TI  - Synthesis and biological evaluation of sulfonilamidothienopyrimidinone 
      derivatives as novel anti-inflammatory agents.
PG  - 700-10
AB  - Eight new sulfonilamidothienopyrimidinone derivatives (1-8) were synthesized and 
      evaluated for their antiinflammatory activity on the human keratinocyte line NCTC 
      2544. The potential anti-inflammatory activity of the derivatives (1-8) was 
      evaluated by determining, through Western blot, the expression of cyclooxygenase 
      (COX)-2, inducible NO synthase (iNOS), intercellular adhesion molecule-1 
      (ICAM-1), and the release of prostaglandins (PG)E2 and interleukin- 8 (IL-8). 
      Moreover, through ELISA assay, the release of monocyte chemoattractant protein-1 
      (MCP-1), and interleukin- 8 (IL-8) was analyzed. Our results demonstrated that 
      the derivatives 3, 5, 6 and 8 act as excellent inhibitors of inflammatory 
      markers: iNOS, COX-2, ICAM-1, MCP-1, and IL-8. These findings could be useful for 
      the development of new drugs for the treatment of various inflammatory 
      pathologies.
FAU - Barone, Mariarita
AU  - Barone M
FAU - Santagati, Andrea
AU  - Santagati A
FAU - Graziano, Adriana C E
AU  - Graziano AC
FAU - Fortuna, Cosimo G
AU  - Fortuna CG
FAU - Ronsisvalle, Giuseppe
AU  - Ronsisvalle G
FAU - Cardile, Venera
AU  - Cardile V
AD  - Department of Biomedical (Physiology), University of Catania, V.le A. Doria 
      6-95125 Catania, Italy. cardile@unict.it.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Med Chem
JT  - Medicinal chemistry (Shariqah (United Arab Emirates))
JID - 101240303
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Bridged Bicyclo Compounds, Heterocyclic)
RN  - 0 (Sulfonamides)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type II)
RN  - EC 1.14.99.1 (Cyclooxygenase 2)
SB  - IM
MH  - Anti-Inflammatory Agents, Non-Steroidal/*chemical 
      synthesis/chemistry/*pharmacology
MH  - Bridged Bicyclo Compounds, Heterocyclic/chemical 
      synthesis/*chemistry/*pharmacology
MH  - Cell Proliferation/drug effects
MH  - Cell Survival/drug effects
MH  - Cells, Cultured
MH  - Cyclooxygenase 2/metabolism
MH  - Humans
MH  - Intercellular Adhesion Molecule-1/biosynthesis/metabolism
MH  - Molecular Structure
MH  - Nitric Oxide Synthase Type II/biosynthesis/metabolism
MH  - Sulfonamides/chemical synthesis/*chemistry/*pharmacology
EDAT- 2014/03/05 06:00
MHDA- 2015/07/04 06:00
CRDT- 2014/03/05 06:00
PHST- 2013/07/17 00:00 [received]
PHST- 2014/02/11 00:00 [revised]
PHST- 2014/02/11 00:00 [accepted]
PHST- 2014/03/05 06:00 [entrez]
PHST- 2014/03/05 06:00 [pubmed]
PHST- 2015/07/04 06:00 [medline]
AID - MC-EPUB-59399 [pii]
AID - 10.2174/1573406410666140228152807 [doi]
PST - ppublish
SO  - Med Chem. 2014;10(7):700-10. doi: 10.2174/1573406410666140228152807.